gene 897 words KG: PPARD
Contents

PPARD Gene

🧬 Gene Info
Gene SymbolPPARD
AliasesPPARδ, PPAR-beta, NR1C2
Chromosome6p21.31
Protein TypeGene
FunctionTarget genes are involved in: - Fatty acid oxidation - Glucose metabolism - Lipid metabolism - Inflammation - Cell proliferation and differentiation
PathwaysAkt, Mapk, Sphingolipid
NCBI Gene ID5468
GeneCardsPPARD
Human Protein AtlasPPARD
Associated Diseasesneurodegeneration
Known Drugs/CompoundsBezafibrate, Kd3010, KD3010, T3D-959
InteractionsPPARGC1A
KG Connections128 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Oligodendrocyte White Matter Vulnerability
Score: 0.65

Related Analyses (4)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Related Experiments (1)

Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40

See Also (15)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: therapeutic_target
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
ADRB2 Gene
gene · KG edge: therapeutic_target
AKT1 Gene
gene · KG edge: regulates
ALDH1A1 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

PPARGC1A activates PPARD
BRG1 therapeutic_target PPARD
EP300 therapeutic_target PPARD
CTNNB1 therapeutic_target PPARD
VEGFA therapeutic_target PPARD
FOXM1 therapeutic_target PPARD
SMARCA4 therapeutic_target PPARD
TERT therapeutic_target PPARD
GAIN therapeutic_target PPARD
PPARD therapeutic_target CLDN1

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