gene

NPY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

306Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NPY is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 58 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NPY
Chromosome	7p15.1
Function	The NPY gene encodes a prepropeptide that undergoes proteolytic processing to yield the mature NPY peptide.
Primary Expression	hippocampus, Hypothalamus, Brainstem, Thalamus, Amygdala
Amino Acids	36 aa
Pathways	Er Stress, Mtor, Lipid Metabolism, Autophagy, Akt
Ensembl ID	ENSG00000157240
GeneCards	NPY
Human Protein Atlas	NPY
Y1 Receptor (NPY1R)	Gi/o-coupled, inhibits adenylate cyclase, activates MAPK pathways, increases intracellular calcium
Y2 Receptor (NPY2R)	Gi/o-coupled, presynaptic inhibition, regulates neurotransmitter release
Y4 Receptor (NPY4R)	Gi/o-coupled, primarily peripheral expression
Y5 Receptor (NPY5R)	Gi/o-coupled, involved in food intake and seizure regulation
Associated Diseases	Als, Alzheimer, Alzheimer's disease, amyotrophic lateral sclerosis
Interactions	ABCA7, ADCY2, AIF1, AKT, Albumin, ALZHEIMER
KG Connections	304 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NPY["NPY"]
    Aging{"Aging"}
    NPY -->|"regulates"| Aging
    Ms{"Ms"}
    NPY -->|"regulates"| Ms
    Obesity{"Obesity"}
    NPY -->|"regulates"| Obesity
    Als{"Als"}
    NPY -->|"regulates"| Als
    NPY -->|"associated with"| Als
    NPY -->|"contributes to"| Ms
    Inflammation{"Inflammation"}
    NPY -->|"activates"| Inflammation
    ALS{"ALS"}
    NPY -->|"regulates"| ALS
    FOOD_INTAKE["FOOD_INTAKE"]
    NPY -->|"activates"| FOOD_INTAKE
    NTS["NTS"]
    NPY -->|"regulates"| NTS
    POMC["POMC"]
    NPY -->|"regulates"| POMC
    MTOR["MTOR"]
    NPY -->|"activates"| MTOR
    ARC["ARC"]
    ARC -->|"produces"| NPY
    CRH["CRH"]
    CRH -->|"regulates"| NPY
    POMC -->|"regulates"| NPY
    NTS -->|"regulates"| NPY
    ARC -->|"regulates"| NPY
    JAK["JAK"]
    JAK -->|"associated with"| NPY
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"contributes to"| NPY
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| NPY
    NPY1R["NPY1R"]
    NPY1R -->|"activates"| NPY
    AND["AND"]
    AND -->|"regulates"| NPY
    style NPY fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (201)

Target	Relation	Type	Str
MAPK/ERK	activates	pathway	0.95
Neurogenesis	promotes	process	0.95
Neuroinflammation	suppresses	process	0.95
Pi3K/Akt	activates	pathway	0.95
P38K	activates	pathway	0.95
Excitotoxicity	protects_against	mechanism	0.95
Huntington'S Disease	implicated_in	disease	0.90
Parkinson'S Disease	implicated_in	disease	0.90
Alzheimer'S Disease	implicated_in	disease	0.90
Food Intake	activates	process	0.88
Synaptic Transmission	involved_in	process	0.85
Disease Progression	biomarker_for	phenotype	0.85
Neuroplasticity	promotes	process	0.85
anxiety-like behavior	inhibits	phenotype	0.85
PI3K/Akt	activates	pathway	0.80
glaucoma	implicated_in	disease	0.80
diabetic retinopathy	implicated_in	disease	0.80
Machado-Joseph disease	implicated_in	disease	0.80
neurogenesis	facilitates	biological_process	0.80
cellular resilience	facilitates	biological_process	0.80
excitotoxicity	alleviates	biological_process	0.80
p38K	activates	pathway	0.80
amyotrophic lateral sclerosis	implicated_in	disease	0.80
Huntington's disease	implicated_in	disease	0.80
Alzheimer's disease	associated_with	disease	0.80
Parkinson's disease	associated_with	disease	0.80
neurons	expressed_in	cell_type	0.80
Cancer	associated_with	disease	0.65
ALS	regulates	disease	0.65
Tumor	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Depression	inhibits	disease	0.65
Asthma	associated_with	disease	0.65
Aging	regulates	disease	0.65
Ms	regulates	disease	0.65
Obesity	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Central Precocious Puberty	implicated_in	disease	0.65
Ischemia	activates	disease	0.65
Insulin Resistance	activates	disease	0.65
Ms	activates	disease	0.65
Als	causes	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Cardiac	activates	disease	0.65
Heart Failure	activates	disease	0.65
Als	associated_with	disease	0.65
Ms	contributes_to	disease	0.65
Inflammation	activates	disease	0.65

Incoming (105)

Source	Relation	Type	Str
BDNF	upregulates	protein	0.90
Ketamine-Aln	upregulates	drug	0.90
Ketamine	upregulates	drug	0.80
ARC	produces	brain_region	0.72
GENES	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
BCL-2	activates	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
CYTOKINES	causes	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
IFN	activates	gene	0.60
IL-6	activates	gene	0.60
TNF-Α	activates	gene	0.60
IFN-Γ	activates	gene	0.60
IGF-1	activates	gene	0.60
GABA	activates	gene	0.60
IL-13	causes	gene	0.60
RNA	causes	gene	0.60
INS	interacts_with	gene	0.60
BDNF	enhances	gene	0.60
CNR2	associated_with	gene	0.60
MTNR1A	associated_with	gene	0.60
CRH	regulates	gene	0.60
POMC	regulates	gene	0.60
NTS	regulates	gene	0.60
ARC	regulates	gene	0.60
ERK1	activates	gene	0.60
AKT	activates	gene	0.60
ABCA7	activates	gene	0.60
BDNF	activates	gene	0.60
SST	activates	gene	0.60
NTS	activates	gene	0.60
CXCL12	associated_with	gene	0.60
ADCY2	associated_with	gene	0.60
GRM2	associated_with	gene	0.60
SLC32A1	associated_with	gene	0.60
BDNF	causes	gene	0.60
STAT6	causes	gene	0.60
neurogenesis	activates	process	0.60
NEFM	activates	gene	0.60
NFM	activates	gene	0.60
HCN1	activates	gene	0.60
HCN1	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
AMPK	activates	gene	0.60
AUTOPHAGY-RELATED GENES	activates	gene	0.60
AND	activates	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
JAK	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NPY in their description or question text

No additional research found

NPY

Understanding Entity Pages

Summary

Wiki Pages (21)

NPY Gene

Neuropeptide Y (NPY) Neurons

NPY5R — Neuropeptide Y Receptor Y5

NPY1R Gene

Neuropeptide Y (NPY) Receptor Modulators in Neurodegeneration

Hypothalamic Arcuate NPY Neurons

NPY-Y1 Receptor Neurons

Cortical NPY Neurons

NPY-Positive Hippocampal Interneurons

Neuropeptide Y (NPY) Neurons (Arcuate)

NPY2R — Neuropeptide Y Receptor Y2

Arcuate NPY/AgRP in Appetite

Striatal NPY Interneurons

Hypothalamic NPY Neurons

Neuropeptide Y (NPY)

AgRP/NPY Neurons

Arcuate Nucleus NPY Neurons

Arcuate Nucleus NPY/AgRP Neurons

Hypothalamic NPY/AgRP Neurons

NPY Protein

NPY-Y5 Receptor Neurons