concept

DISEASE PROGRESSION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DISEASE PROGRESSION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

1Hypotheses

3Analyses

2Outgoing

50Incoming

0Experiments

6Debates

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💡 Concept Info

Name	DISEASE PROGRESSION

Pathway Diagram

graph TD
    DISEASE_PROGRESSION["DISEASE PROGRESSION"]
    DISEASE_PROGRESSION -->|"involved_in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    Neuroinflammation["Neuroinflammation"] -->|"regulates"| DISEASE_PROGRESSION
    Extracellular_Matrix["Extracellular Matrix"] -->|"contributes to"| DISEASE_PROGRESSION
    Neuronal_Damage["Neuronal Damage"] -->|"contributes to"| DISEASE_PROGRESSION
    Neurodegeneration_Markers["Neurodegeneration Markers"] -->|"correlates_with"| DISEASE_PROGRESSION
    Poor_Cognitive_Function["Poor Cognitive Function"] -->|"correlates_with"| DISEASE_PROGRESSION
    Oligodendrocytes["Oligodendrocytes"] -->|"contributes to"| DISEASE_PROGRESSION
    Astrocytes["Astrocytes"] -->|"contributes to"| DISEASE_PROGRESSION
    NDNF_Overexpression["NDNF Overexpression"] -->|"inhibits"| DISEASE_PROGRESSION

Outgoing (2)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	involved_in	disease	0.85
Neuroinflammation	associated_with	process	0.85

Incoming (61)

Source	Relation	Type	Str
Donanemab	inhibits	drug	0.95
PI3K/Akt/mTOR	involved_in	pathway	0.90
PIKFYVE	inhibits	protein	0.90
Somatic Mutations In Hematopoietic Stem Cells	contributes_to	process	0.90
39640195	is independent biomarker of	paper	0.90
36922834	modify	paper	0.90
Neuroinflammation	regulates	process	0.90
39827337	exacerbate	paper	0.90
39640195	acts as independent biomarker of	paper	0.90
39640195	acted as independent biomarkers of	paper	0.90
29686391	is a marker for	paper	0.90
Abnormal Stress Granule Accumulation	contributes_to	phenotype	0.90
Extracellular Matrix	contributes_to	process	0.88
PIKFYVE inhibition	associated_with	process	0.88
Neuronal Damage	contributes_to	phenotype	0.87
Neurodegeneration Markers	correlates_with	biomarker	0.87
pS65-Ubiquitin	correlates_with	biomarker	0.85
Poor Cognitive Function	correlates_with	phenotype	0.85
Cerebrospinal Fluid	associated_with	biomarker	0.85
SNCA fibril polymorphs	contributes_to	protein	0.85
Astrocytes	contributes_to	cell_type	0.85
Extracellular Matrix	modulates	process	0.85
Tofersen	suppresses	drug	0.85
Cerebral Perfusion	correlates_with	biomarker	0.85
SNCA	contributes_to	protein	0.85
Mitochondria	involved_in	cell_type	0.85
Neuromodulation	modulates	process	0.85
Gray Matter Perfusion	correlates_with	biomarker	0.85
NPY	biomarker_for	protein	0.85
NDNF Overexpression	inhibits	process	0.85
Amyloid Clearance	modulates	process	0.85
Early Treatment Initiation	suppresses	mechanism	0.85
Gene Therapy	modulates	drug	0.85
Amyotrophic Lateral Sclerosis	causes	disease	0.85
Oligodendrocytes	contributes_to	cell_type	0.85
Metabolomic Profiles	biomarker_for	biomarker	0.82
MTOR	associated_with	pathway	0.82
Protective Genetic Variants	modulates	biomarker	0.82
RELN	modulates	gene	0.80
Cell-To-Cell Transmission	contributes_to	process	0.80
Tumor Diversity	associated_with	phenotype	0.80
M1 Microgliosis	contributes_to	cell_type	0.80
Neuromodulation	inhibits	process	0.75
Astrogliosis	contributes_to	process	0.75
ncRNA-based therapies	suppresses	drug	0.75
Differentially Expressed Genes	biomarker_for	biomarker	0.75
Ncrna-Based Therapies	suppresses	drug	0.75
SARM1	involved_in	gene	0.75
intercellular propagation	promotes	process	0.70
TMEM106B genetic variation	regulates	gene	0.70