gene

GAD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

0Hypotheses

0Analyses

41Outgoing

24Incoming

0Experiments

0Debates

Summary

GAD2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, implicated in. Associated with Als, Cardiac, Diabetes. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GAD2
Full Name	Glutamate Decarboxylase 2
Chromosome	10p12.1
Protein Type	Receptor
Function	It plays critical roles in ciliary signaling, neuronal migration, and synaptic function.
Primary Expression	regions affected in Parkinson disease
UniProt ID	Q96S44
NCBI Gene ID	2572
Ensembl ID	ENSG00000136750
OMIM	300036
GeneCards	GAD2
Human Protein Atlas	GAD2
Associated Diseases	Als
Interactions	DEPRESSION, GAD1, PVALB, Ras, TRKB
KG Connections	65 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GAD2 — AlphaFold Q96S44 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Glutamate Decarboxylase 2

gene · 917 words

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Pathway Diagram

graph TD
    GAD2["GAD2"]
    Als{"Als"}
    GAD2 -->|"associated with"| Als
    Cardiac{"Cardiac"}
    GAD2 -->|"regulates"| Cardiac
    Diabetes{"Diabetes"}
    GAD2 -->|"regulates"| Diabetes
    GAD2 -->|"regulates"| Als
    PIK3CB["PIK3CB"]
    GAD2 -->|"regulates"| PIK3CB
    NOS1["NOS1"]
    GAD2 -->|"regulates"| NOS1
    CFTR["CFTR"]
    GAD2 -->|"regulates"| CFTR
    EPHB4["EPHB4"]
    GAD2 -->|"associated with"| EPHB4
    MMP2["MMP2"]
    GAD2 -->|"associated with"| MMP2
    HIP1R["HIP1R"]
    GAD2 -->|"regulates"| HIP1R
    USH1C["USH1C"]
    GAD2 -->|"regulates"| USH1C
    neurodegeneration["neurodegeneration"]
    GAD2 -->|"implicated in"| neurodegeneration
    RYR2["RYR2"]
    RYR2 -->|"regulates"| GAD2
    SCN1A["SCN1A"]
    SCN1A -->|"regulates"| GAD2
    ROBO1["ROBO1"]
    ROBO1 -->|"associated with"| GAD2
    ABCD3["ABCD3"]
    ABCD3 -->|"regulates"| GAD2
    HNF4A["HNF4A"]
    HNF4A -->|"expressed in"| GAD2
    style GAD2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (41)

Target	Relation	Type	Str
Depression	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Als	associated_with	disease	0.65
STAT3	therapeutic_target	gene	0.60
MAPK8	therapeutic_target	gene	0.60
TRKB	inhibits	gene	0.60
SST	regulates	gene	0.60
TP53	therapeutic_target	gene	0.60
GABA	regulates	gene	0.60
Interneuron	regulates	cell_type	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
Neuron	regulates	cell_type	0.60
ACHE	therapeutic_target	gene	0.60
Lipid Metabolism	therapeutic_target	pathway	0.60
Synaptic Plasticity	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
BDNF	regulates	gene	0.60
GAD1	inhibits	gene	0.60
PVALB	inhibits	gene	0.60
NPY	regulates	gene	0.60
Ras	inhibits	protein	0.60
neurons	expressed_in	cell_type	0.60
DEPRESSION	inhibits	gene	0.60
Bdnf	regulates	protein	0.60
PIK3CB	regulates	gene	0.60
NOS1	regulates	gene	0.60
CFTR	regulates	gene	0.60
EPHB4	associated_with	gene	0.60
MMP2	associated_with	gene	0.60
HIP1R	regulates	gene	0.60
USH1C	regulates	gene	0.60
Neuron	expressed_in	cell_type	0.55
Cortex	expressed_in	brain_region	0.55
inhibitory neurons	expressed_in	cell_type	0.55
Interneuron	expressed_in	cell_type	0.55
Amygdala	expressed_in	brain_region	0.55
INTERNEURONS	regulates	concept	0.50

Incoming (24)

Source	Relation	Type	Str
GENES	regulates	gene	0.60
GABA	regulates	gene	0.60
AND	regulates	gene	0.60
PPARG	therapeutic_target	gene	0.60
MAOA	therapeutic_target	gene	0.60
PRKCA	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
ARG1	therapeutic_target	gene	0.60
NOS3	therapeutic_target	gene	0.60
NPY	regulates	gene	0.60
RYR2	regulates	gene	0.60
SCN1A	regulates	gene	0.60
ROBO1	associated_with	gene	0.60
ABCD3	regulates	gene	0.60
HNF4A	expressed_in	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
DEPRESSION	inhibits	gene	0.60
GAD1	inhibits	gene	0.60
BDNF	regulates	gene	0.60
TRKB	inhibits	gene	0.60
SST	regulates	gene	0.60
PVALB	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GAD2 in their description or question text

No additional research found