gene

C3AR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C3AR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

204Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

C3AR1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in, regulates. Associated with Aging, Als, Alzheimer. Connected to 72 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	C3AR1
Full Name	Complement C3a Receptor 1
Chromosome	5p13.3
Protein Type	Receptor
Function	C3AR1 encodes a seven-transmembrane G protein-coupled receptor that specifically binds the complement activation fragment C3a.
Pathways	BLOOD_CSF_BARRIER
UniProt ID	Q16581
NCBI Gene ID	719
Ensembl ID	ENSG00000171860
GeneCards	C3AR1
Human Protein Atlas	C3AR1
Associated Diseases	Aging, Als, Alzheimer, Cancer, Cardiovascular
Known Drugs/Compounds	SB290157
Interactions	adcy2, ADCY2, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS
KG Connections	204 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: C3AR1 — AlphaFold Q16581 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

C3AR1 Gene

gene · 870 words

→

Pathway Diagram

graph TD
    C3AR1["C3AR1"]
    Glioblastoma{"Glioblastoma"}
    C3AR1 -->|"activates"| Glioblastoma
    Tumor{"Tumor"}
    C3AR1 -->|"activates"| Tumor
    Dementia{"Dementia"}
    C3AR1 -->|"regulates"| Dementia
    Glioma{"Glioma"}
    C3AR1 -->|"associated with"| Glioma
    BLOOD_CSF_BARRIER(["BLOOD_CSF_BARRIER"])
    C3AR1 -->|"regulates"| BLOOD_CSF_BARRIER
    M2_POLARIZATION["M2_POLARIZATION"]
    C3AR1 -->|"regulates"| M2_POLARIZATION
    MICROGLIAL_RECRUITMENT["MICROGLIAL_RECRUITMENT"]
    C3AR1 -->|"regulates"| MICROGLIAL_RECRUITMENT
    Complement(["Complement"])
    C3AR1 -->|"associated with"| Complement
    GBM["GBM"]
    C3AR1 -->|"expressed in"| GBM
    GENES["GENES"]
    C3AR1 -->|"biomarker for"| GENES
    DNA["DNA"]
    C3AR1 -->|"regulates"| DNA
    RBPJL["RBPJL"]
    C3AR1 -->|"biomarker for"| RBPJL
    C3A["C3A"]
    C3A -->|"activates"| C3AR1
    SB290157["SB290157"]
    SB290157 -->|"inhibits"| C3AR1
    C3["C3"]
    C3 -->|"activates"| C3AR1
    HYPOXIA["HYPOXIA"]
    HYPOXIA -->|"activates"| C3AR1
    GBM -->|"expressed in"| C3AR1
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"associated with"| C3AR1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| C3AR1
    GLIOBLASTOMA["GLIOBLASTOMA"]
    GLIOBLASTOMA -->|"activates"| C3AR1
    AND["AND"]
    AND -->|"expressed in"| C3AR1
    style C3AR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (132)

Target	Relation	Type	Str
Neuroinflammation	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Dementia	implicated_in	disease	0.65
Glioblastoma	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	regulates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Glioma	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Tumor	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Parkinson	associated_with	disease	0.65
Aging	associated_with	disease	0.65
M2_POLARIZATION	regulates	phenotype	0.64
BLOOD_CSF_BARRIER	regulates	pathway	0.64
MICROGLIAL_RECRUITMENT	regulates	phenotype	0.64
CANCER	associated_with	gene	0.60
Stem Cell	associated_with	pathway	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
NF-KB	associated_with	gene	0.60
Macrophage	associated_with	cell_type	0.60
Gut Microbiome	associated_with	pathway	0.60
Dysbiosis	associated_with	pathway	0.60
Immune Response	associated_with	pathway	0.60
COMPLEMENT	associated_with	gene	0.60
Notch	biomarker_for	pathway	0.60
Neuron	associated_with	cell_type	0.60
Microglia	activates	cell_type	0.60
GENES	biomarker_for	gene	0.60
MICROGLIA	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
AND	expressed_in	gene	0.60
DNA	regulates	gene	0.60
Complement	associated_with	pathway	0.60
Macrophage	activates	cell_type	0.60
Adaptive Immunity	implicated_in	pathway	0.60
Microglia	associated_with	cell_type	0.60
MICROGLIA	associated_with	gene	0.60
Notch	implicated_in	pathway	0.60
Adaptive Immunity	biomarker_for	pathway	0.60
DEMENTIA	implicated_in	gene	0.60
DNA	implicated_in	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60

Incoming (72)

Source	Relation	Type	Str
C3A	activates	protein	0.87
C3	activates	protein	0.72
SB290157	inhibits	drug	0.72
HYPOXIA	activates	phenotype	0.64
ALZHEIMER	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
FTLD	implicated_in	gene	0.60
AGING	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
NF-KB	associated_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
APOPTOSIS	activates	gene	0.60
NOTCH	biomarker_for	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
GENES	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
FTLD	biomarker_for	gene	0.60
DEMENTIA	regulates	gene	0.60
DNA	regulates	gene	0.60
GENES	biomarker_for	gene	0.60
TBK1	associated_with	gene	0.60
RBPJL	associated_with	gene	0.60
UNC13A	regulates	gene	0.60
MICROGLIA	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CCR1	associated_with	gene	0.60
C1QB	associated_with	gene	0.60
CD4	associated_with	gene	0.60
AIF1	associated_with	gene	0.60
CD163	associated_with	gene	0.60
CYBB	associated_with	gene	0.60
CSF1R	associated_with	gene	0.60
C1QA	associated_with	gene	0.60
TBK1	biomarker_for	gene	0.60
COMPLEMENT	associated_with	gene	0.60
ANO9	biomarker_for	gene	0.60
RBPJL	biomarker_for	gene	0.60
C3	interacts_with	gene	0.60
C3	expressed_in	gene	0.60
ADCY2	interacts_with	gene	0.60
GBM	expressed_in	gene	0.60
TREM2	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
ANO9	implicated_in	gene	0.60
SIRT1	associated_with	gene	0.60
STING	associated_with	gene	0.60
HMGB1	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
CXCL12	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning C3AR1 in their description or question text

No additional research found