gene

CCR5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCR5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

280Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CCR5 is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, therapeutic target. Associated with Als, Cardiovascular, Dementia. Connected to 73 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CCR5
Aliases	CCR5 chemokine receptor
Protein Type	Gene
Function	CCR5 is a seven-transmembrane G protein-coupled receptor that binds CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL5 (RANTES).
Molecular Weight	46 kDa
Amino Acids	352 aa
Pathways	MAPK, PI3K
UniProt ID	P51681
GeneCards	CCR5
Human Protein Atlas	CCR5
N-terminal extracellular domain	Contains glycosylation sites and contributes to ligand binding specificity
Extracellular loops (ECL1-3)	Form the ligand-binding pocket for chemokines
Transmembrane domains (TM1-7)	Spanning the cell membrane, connecting to intracellular signaling
Intracellular loops (ICL1-3)	Couple to G proteins and β-arrestin
C-terminal intracellular tail	Contains serine/threonine residues for phosphorylation and regulation
Associated Diseases	Als, Alzheimer, Inflammation, Neuroinflammation, Ptsd
Interactions	adcy2, ADCY2, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AND
KG Connections	280 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CCR5 — AlphaFold P51681 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CCR5["CCR5"]
    PI3K["PI3K"]
    CCR5 -->|"activates"| PI3K
    Huntington{"Huntington"}
    CCR5 -->|"activates"| Huntington
    Tauopathy{"Tauopathy"}
    CCR5 -->|"activates"| Tauopathy
    Neurodegeneration{"Neurodegeneration"}
    CCR5 -->|"inhibits"| Neurodegeneration
    Dementia{"Dementia"}
    CCR5 -->|"interacts with"| Dementia
    Als{"Als"}
    CCR5 -->|"interacts with"| Als
    Ms{"Ms"}
    CCR5 -->|"interacts with"| Ms
    CCR5 -->|"therapeutic target"| Als
    CCR5 -->|"therapeutic target"| Ms
    Stroke{"Stroke"}
    CCR5 -->|"inhibits"| Stroke
    Ischemia{"Ischemia"}
    CCR5 -->|"therapeutic target"| Ischemia
    Cardiovascular{"Cardiovascular"}
    CCR5 -->|"therapeutic target"| Cardiovascular
    CCL3["CCL3"]
    CCL3 -->|"activates"| CCR5
    CCL4["CCL4"]
    CCL4 -->|"activates"| CCR5
    CCL5["CCL5"]
    CCL5 -->|"activates"| CCR5
    CCL5 -->|"inhibits"| CCR5
    AKT["AKT"]
    AKT -->|"activates"| CCR5
    PI3K -->|"activates"| CCR5
    LC3B["LC3B"]
    LC3B -->|"interacts with"| CCR5
    FIS1["FIS1"]
    FIS1 -->|"interacts with"| CCR5
    MFN2["MFN2"]
    MFN2 -->|"interacts with"| CCR5
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"therapeutic target"| CCR5
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| CCR5
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"inhibits"| CCR5
    style CCR5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (186)

Target	Relation	Type	Str
PI3K	activates	gene	0.90
Mtor	activates	pathway	0.80
Huntington	activates	disease	0.75
Tauopathy	activates	disease	0.75
Autophagy	activates	pathway	0.70
neurons	expressed_in	cell_type	0.70
ALS	interacts_with	disease	0.65
Autoimmune	inhibits	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
Traumatic Brain Injury	treats	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Neurodegeneration	treats	disease	0.65
Ms	therapeutic_target	disease	0.65
Stroke	inhibits	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Alzheimer	interacts_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Multiple Sclerosis	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Autoimmune	activates	disease	0.65
Ischemia	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
ALS	activates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Als	interacts_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Diabetes	activates	disease	0.65
Dementia	interacts_with	disease	0.65
Ptsd	associated_with	disease	0.65
IL-6	inhibits	gene	0.60
INFLAMMATION	activates	gene	0.60
Innate Immunity	activates	pathway	0.60
HUNTINGTON'S DISEASE	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
TAUOPATHY	activates	gene	0.60
IL-1	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
DIABETES MELLITUS	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60

Incoming (94)

Source	Relation	Type	Str
CCL5	activates	gene	1.00
CCL3	activates	gene	0.90
CCL4	activates	gene	0.90
MTORC1	activates	gene	0.70
TAUOPATHY	activates	gene	0.70
NEURODEGENERATIVE DISEASES	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
HUNTINGTON	activates	gene	0.70
MFN2	interacts_with	gene	0.60
CCL2	expressed_in	gene	0.60
AND	activates	gene	0.60
MICROGLIA	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
FIS1	interacts_with	gene	0.60
HDAC3	inhibits	gene	0.60
PYROPTOSIS	activates	gene	0.60
CXCR4	treats	gene	0.60
MTOR	activates	gene	0.60
CGAS	therapeutic_target	gene	0.60
PKC	therapeutic_target	gene	0.60
REELIN	activates	gene	0.60
CXCL12	associated_with	gene	0.60
ADCY2	associated_with	gene	0.60
GRM2	associated_with	gene	0.60
NPY	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
CCR1	inhibits	gene	0.60
CXCR3	inhibits	gene	0.60
PSD95	activates	gene	0.60
CDH23	associated_with	gene	0.60
HAPLN1	associated_with	gene	0.60
MTNR1A	associated_with	gene	0.60
C3AR1	associated_with	gene	0.60
CCL3	inhibits	gene	0.60
TNF	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
P2RY12	associated_with	gene	0.60
CXCL10	inhibits	gene	0.60
CCR2	expressed_in	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
CCL5	inhibits	gene	0.60
AKT	activates	gene	0.60
PI3K	activates	gene	0.60
SYNAPTOPHYSIN	treats	gene	0.60
PSD95	treats	gene	0.60
CXCR4	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CCR5 in their description or question text

No additional research found