| Gene Symbol | NPY |
| Aliases | NPYPROTEIN |
| Chromosome | 7p15.1 |
| Function | The NPY gene encodes a prepropeptide that undergoes proteolytic processing to yield the mature NPY peptide. |
| Primary Expression | hippocampus, Hypothalamus, Brainstem, Thalamus, Amygdala |
| Subcellular Localization | </strong></td><td>Secreted peptide (dense-core vesicles)</td></tr> |
| Amino Acids | 36 aa |
| Pathways | Er Stress, Mtor, Lipid Metabolism, Autophagy, Akt |
| Ensembl ID | ENSG00000157240 |
| GeneCards | NPY |
| Human Protein Atlas | NPY |
| PP-fold motif | NPY shares the pancreatic polypeptide fold with peptide YY (PYY) and pancreatic polypeptide (PP) |
| N-terminal coil | Important for receptor binding specificity |
| C-terminal tail | Essential for receptor activation |
| Amidation | C-terminal Tyr36 is amidated, crucial for biological activity |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease, amyotrophic lateral sclerosis |
| Interactions | ABCA7, ADCY2, AIF1, AKT, Albumin, ALZHEIMER |
| KG Connections | 300 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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