gene

GLAUCOMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLAUCOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1000Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	GLAUCOMA
Aliases	Open-angle glaucoma, Angle-closure glaucoma
Age	Glaucoma prevalence increases exponentially with age, reflecting cumulative damage and reduced regenerative capacity.
Genetics	Family history increases risk 4-10 fold. Multiple susceptibility loci have been identified (MYOC, OPTN, WDR36, CAV1/CAV2).
Ethnicity	African and Hispanic populations have higher prevalence and earlier onset.
Central Corneal Thickness	Thinner corneas are associated with higher glaucoma risk.
Topical Medications	Prostaglandin analogs (latanoprost, bimatoprost), beta-blockers, alpha-agonists, carbonic anhydrase inhibitors
Laser Therapy	Selective laser trabeculoplasty (SLT)
Surgical	Trabeculectomy, tube shunts, MIGS (minimally invasive glaucoma surgery)
Associated Diseases	aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis
Interactions	Actin, AGING, AHR, Akt, AKT, ALZHEIMER
KG Connections	493 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

retinal-ganglion-cells-glaucoma

cell_type · 1594 words

→

Pathway Diagram

graph TD
    GLAUCOMA["GLAUCOMA"] -->|"associated"| PIEZO1["PIEZO1"]
    style PIEZO1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| STROKE["STROKE"]
    style STROKE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| NEURODEGENERATION["NEURODEGENERATION"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    style NEUROINFLAMMATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| NLRP3["NLRP3"]
    style NLRP3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"regulates"| NEUROPROTECTION["NEUROPROTECTION"]
    style NEUROPROTECTION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| SIRT6["SIRT6"]
    style SIRT6 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AHR["AHR"] -.->|"inhibits"| GLAUCOMA["GLAUCOMA"]
    style AHR fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    CFB["CFB"] -->|"activates"| GLAUCOMA["GLAUCOMA"]
    style CFB fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    DEPRESSION["DEPRESSION"] -->|"contributes to"| GLAUCOMA["GLAUCOMA"]
    style DEPRESSION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"implicated in"| GLAUCOMA["GLAUCOMA"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AXON["AXON"] -->|"associated"| GLAUCOMA["GLAUCOMA"]
    style AXON fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style GLAUCOMA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (472)

Target	Relation	Type	Str
Retinal Ganglion Cell Death	causes	process	0.95
Complement, Inflammasome, and Microglial Crosstalk	associated_with	mechanism	0.95
Retinal Ganglion Cell	associated_with	cell_type	0.95
Retinal Ganglion Cell Loss	causes	phenotype	0.95
Optic Nerve Degeneration	causes	phenotype	0.95
Retinal Ganglion Cell Degeneration	causes	process	0.95
Vision Loss	causes	phenotype	0.95
Amyotrophic Lateral Sclerosis	associated_with	disease	0.85
Tryptophan Metabolism	associated_with	pathway	0.80
MAPK	associated_with	pathway	0.70
Autophagy	therapeutic_target	pathway	0.70
retinal ganglion cells	causes	cell_type	0.70
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Multiple Sclerosis	contributes_to	disease	0.65
Alzheimer	contributes_to	disease	0.65
Stroke	contributes_to	disease	0.65
Epilepsy	regulates	disease	0.65
Cancer	regulates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Obesity	regulates	disease	0.65
Alzheimer	causes	disease	0.65
Parkinson	causes	disease	0.65
Huntington	causes	disease	0.65
Retinitis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Macular Degeneration	associated_with	disease	0.65
Macular Degeneration	causes	disease	0.65
Obesity	contributes_to	disease	0.65
Pyroptosis	therapeutic_target	disease	0.65
Anxiety	contributes_to	disease	0.65
Aging	associated_with	disease	0.65
Glaucoma	inhibits	disease	0.65
Ferroptosis	therapeutic_target	disease	0.65
ALS	protects_against	disease	0.65
Depression	contributes_to	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Parkinson	activates	disease	0.65
Aging	activates	disease	0.65
Glaucoma	protects_against	disease	0.65
Ischemia	contributes_to	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	expressed_in	disease	0.65
Glaucoma	activates	disease	0.65
Senescence	activates	disease	0.65
ALS	expressed_in	disease	0.65
Inflammation	inhibits	disease	0.65
Aging	expressed_in	disease	0.65

Incoming (528)

Source	Relation	Type	Str
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
OPTN	associated_with	gene	0.95
NEURODEGENERATION	associated_with	gene	0.95
Microbiota	contributes_to	process	0.95
OPTN	associated_with	gene	0.95
Redox Imbalance	contributes_to	process	0.95
Elevated Intraocular Pressure	risk_factor_for	phenotype	0.95
Retinal Ganglion Cell Loss	causes	process	0.95
Complement-Nlrp3-Microglia Axis	causes	pathway	0.90
ocular hypertension	risk_factor_for	phenotype	0.90
Lps-Tlr4 Pathway	involved_in	pathway	0.90
NLRP3 INFLAMMASOME	involved_in	protein	0.90
family history	risk_factor_for	phenotype	0.90
Neuroinflammation	involved_in	process	0.90
Gut Microbiota	protects_against	process	0.90
Intraocular Pressure	risk_factor_for	biomarker	0.90
astrocyte network	therapeutic_target	cell_type	0.90
Complement	associated_with	pathway	0.90
Neurodegeneration	associated_with	process	0.90
AHR/RAGE Pathway	involved_in	pathway	0.90
Tryptophan Metabolites	protects_against	compound	0.88
Indoleacetic Acid	treats	compound	0.88
Perivascular Niche	protects_against	process	0.88
Aging	risk_factor_for	process	0.88
AHR/RAGE Pathway	protects_against	pathway	0.85
Neuroprotection	protects_against	process	0.85
Gut Microbiota	associated_with	process	0.85
NLRP3	associated_with	protein	0.85
C1Q	involved_in	protein	0.85
C3	involved_in	protein	0.85
inflammatory factor release	promotes	process	0.85
Indoleacetic Acid	therapeutic_target	compound	0.85
C5	involved_in	protein	0.85
Genetics	risk_factor_for	process	0.85
Age	risk_factor_for	biomarker	0.85
NEURODEGENERATIVE DISEASES	associated_with	gene	0.85
Retinal Ganglion Cell Loss	biomarker_for	phenotype	0.85
AhR	protects_against	protein	0.82
Intraocular Pressure Lowering	treats	process	0.80
Serum Indoleacetic Acid	biomarker_for	biomarker	0.80
Direction-Selective Rgc	protects_against	cell_type	0.80
APOE3	contributes_to	protein	0.80
Piezo1	implicated_in	protein	0.80
NLRP3 Inflammasome	associated_with	pathway	0.80
NLRP3	activates	protein	0.80
Microglia	associated_with	cell_type	0.80
dysbiosis	promotes	process	0.80
C5	upregulates	protein	0.80
MTOR	therapeutic_target	gene	0.80
Obesity	contributes_to	phenotype	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GLAUCOMA in their description or question text

No additional research found