concept

EXCITOTOXICITY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXCITOTOXICITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

346Connections

1Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

6Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	EXCITOTOXICITY
Key Genes/Proteins	AKT, AMPK, AMYLOID, AMYLOID-BETA, amyotrophic lateral sclerosis
Related Diseases	ALS, Alzheimer'S Disease, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Excitotoxicity in Neurodegeneration

mechanism · 4129 words

→

Pathway Diagram

graph TD
    EXCITOTOXICITY["EXCITOTOXICITY"]
    EXCITOTOXICITY -->|"causes"| Neurotoxicity["Neurotoxicity"]
    EXCITOTOXICITY -->|"causes"| STIM1["STIM1"]
    EXCITOTOXICITY -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    EXCITOTOXICITY -->|"inhibits"| FOXO3["FOXO3"]
    EXCITOTOXICITY -->|"activates"| NEURON["NEURON"]
    EXCITOTOXICITY -->|"activates"| STING["STING"]
    EXCITOTOXICITY -->|"promotes"| HIPPOCAMPUS["HIPPOCAMPUS"]
    EXCITOTOXICITY -->|"promotes"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    EXCITOTOXICITY -->|"regulates"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    glutamate_receptors["glutamate receptors"] -->|"causes"| EXCITOTOXICITY
    Glutamate["Glutamate"] -->|"causes"| EXCITOTOXICITY
    Glutamate_receptors["Glutamate receptors"] -->|"mediates"| EXCITOTOXICITY
    NAD_metabolism["NAD metabolism"] -->|"participates in"| EXCITOTOXICITY
    GLUTAMATE["GLUTAMATE"] -->|"causes"| EXCITOTOXICITY
    glutamate["glutamate"] -->|"causes"| EXCITOTOXICITY
    ginsenosides["ginsenosides"] -->|"inhibits"| EXCITOTOXICITY
    inflammation["inflammation"] -->|"causes"| EXCITOTOXICITY
    GLUTAMATE_RECEPTORS["GLUTAMATE_RECEPTORS"] -->|"causes"| EXCITOTOXICITY

Outgoing (158)

Target	Relation	Type	Str
Neurotoxicity	causes	process	0.90
Calcium Overload	associated_with	process	0.90
Stroke	contributes_to	disease	0.90
Motor Neuron Death	causes	process	0.90
Ischemic Stroke	contributes_to	disease	0.90
Motor Neuron Degeneration	contributes_to	phenotype	0.85
Ferroptosis	activates	pathway	0.70
ERK	regulates	gene	0.70
Amyotrophic lateral sclerosis	associated_with	disease	0.70
CELL DEATH	activates	phenotype	0.70
FERROPTOSIS	inhibits	phenotype	0.65
FERROPTOSIS	activates	phenotype	0.65
FERROPTOSIS	targets	phenotype	0.65
AMPK	activates	gene	0.65
UBIQUITIN	degrades	protein	0.65
NECROPTOSIS	activates	phenotype	0.65
AXONAL DEGENERATION	activates	phenotype	0.65
NECROPTOSIS	regulates	phenotype	0.65
FERROPTOSIS	causes	phenotype	0.65
STIM1	causes	protein	0.64
MIRO1	associated_with	gene	0.60
SST	activates	gene	0.60
STIM1	activates	gene	0.60
neuroinflammation	associated_with	process	0.60
oxidative stress	regulates	process	0.60
TRKB	associated_with	gene	0.60
TET2	activates	gene	0.55
VGLUT1	inhibits	gene	0.55
HK2	activates	gene	0.55
TFEB	activates	gene	0.55
ULK1	activates	gene	0.55
PARKINSON'S DISEASE	participates_in	disease	0.55
SPINAL CORD	associated_with	brain_region	0.55
PROTEIN AGGREGATION	associated_with	process	0.50
GABA	co_discussed	entity	0.50
GABAergic	co_discussed	entity	0.50
INFLAMMASOME	co_discussed	entity	0.50
NLRP3	co_discussed	entity	0.50
NMDA	co_discussed	entity	0.50
MLKL	co_discussed	entity	0.50
NECROPTOSIS	co_discussed	entity	0.50
PSD95	co_discussed	entity	0.50
MS	co_discussed	entity	0.50
NEURON	causes	entity	0.50
RIPK1	co_discussed	entity	0.50
RIPK3	co_discussed	entity	0.50
LOCUS COERULEUS	co_discussed	entity	0.50
GLUTAMATE	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
FOXO3	co_discussed	entity	0.50

Incoming (188)

Source	Relation	Type	Str
NPY	protects_against	protein	0.95
Oligodendrocyte	mediates	cell_type	0.90
Astrocyte	mediates	cell_type	0.90
39602529	were neuroprotective against	paper	0.90
glutamate receptors	causes	protein	0.90
Glutamate receptors	mediates	receptor	0.90
Glutamate	causes	entity	0.90
Glutamate Receptor Accumulation	contributes_to	process	0.85
CYTOKINES	associated_with	protein	0.85
Astrocytes	contributes_to	cell_type	0.85
Glutamate Receptor Accumulation	causes	mechanism	0.85
NAD metabolism	participates_in	biological_process	0.80
SOD1	mediates	protein	0.80
NPY	alleviates	gene	0.80
HMGCR	inhibits	gene	0.80
GLUTAMATE	causes	drug	0.72
glutamate	causes	protein	0.70
TREM2 upregulation in DAM cells	causes	mechanism	0.70
VGLUT1 terminals	vulnerable_to	cell_type	0.70
SYNAPTIC PLASTICITY	causes	phenotype	0.70
NPTX2 downregulation	causes	mechanism	0.70
inflammation	causes	process	0.70
GABA	protects_against	phenotype	0.70
GABA	inhibits	phenotype	0.70
SLC7A11	causes	protein	0.70
ginsenosides	inhibits	drug	0.70
glutamate_receptors	causes	protein	0.68
GLUTAMATE_RECEPTORS	causes	protein	0.68
ASTROCYTES	exacerbates	cell_type	0.65
STROKE	causes	disease	0.65
ALZHEIMER'S DISEASE	implicated_in	disease	0.65
BDNF	activates	gene	0.65
LOCUS COERULEUS	causes	brain_region	0.65
ROS	inhibits	phenotype	0.65
ASTROCYTE	causes	cell_type	0.65
KYNURENINE PATHWAY	activates	pathway	0.65
SLC1A2	protects_against	gene	0.60
SLC1A3	protects_against	gene	0.60
AKT	activates	gene	0.58
ALZHEIMER'S DISEASE	activates	disease	0.58
GABA	expressed_in	phenotype	0.55
GLUTAMATE	associated_with	phenotype	0.55
autophagy	activates	pathway	0.55
SYNAPSE	associated_with	concept	0.50
DOPAMINERGIC	co_discussed	entity	0.50
CDK5	co_discussed	entity	0.50
Neurodegeneration	associated_with	disease	0.50
amyotrophic lateral sclerosis	associated_with	gene	0.50
MOTOR NEURON	activates	concept	0.50
NEURONS	activates	concept	0.50