gene

SLC32A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC32A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

117Connections

0Hypotheses

0Analyses

50Outgoing

45Incoming

0Experiments

0Debates

Summary

A gene referenced in 103 knowledge graph relationships. Key connections: participates_in autophagy pathway (pathway); therapeutic_target Necroptosis (disease); therapeutic_target Pyroptosis (disease).

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🧬 Gene Info

Gene Symbol	SLC32A1
Function	SLC32A1 encodes the vesicular GABA transporter (VGAT), also known as the vesicular inhibitory amino acid transporter (VIAAT).
Pathways	autophagy pathway, Apoptosis, Necroptosis, Pyroptosis
Ensembl ID	ENSG00000103838
GeneCards	SLC32A1
Human Protein Atlas	SLC32A1
GABAergic Transmission	In GABAergic neurons, VGAT packages GABA for use in inhibitory synaptic transmission throughout the brain and spinal cord.
Glycinergic Transmission	In glycinergic neurons (primarily in the spinal cord and brainstem), VGAT packages glycine for inhibitory neurotransmission.
Mixed Transmission	Some neurons may release both GABA and glycine, particularly during development or in specific brain regions.
Onset	Seizures typically begin in infancy or early childhood
Phenotypes	Patients may present with infantile spasms, Lennox-Gastaut syndrome, or other epileptic encephalopathy patterns
Mechanism	Reduced GABA release from inhibitory interneurons disinhibits excitatory circuits, leading to seizure generation
Outcome	Many patients show intellectual disability and persistent seizures despite aggressive treatment
Inhibitory Circuit Development	Disrupted inhibitory neurotransmission during critical developmental periods may alter circuit formation and plasticity
E/I Balance	Imbalanced excitation-inhibition during development can have lasting effects on cognitive function and social behavior
Associated Diseases	Als, Cancer, Tumor
Interactions	GAD1, GRIA2, INS, NPY, PVALB, SLC17A6
KG Connections	103 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

slc32a1

gene · 1508 words

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Pathway Diagram

flowchart TD
    SLC["SLC32A1 Gene"]
    VGAT["VGAT Vesicular Transporter"]
    GABA["GABA Loading"]
    GLY["Glycine Loading"]
    VES["Inhibitory Synaptic Vesicle"]
    RELEASE["Vesicle Exocytosis"]
    INHIB["Inhibitory Neurotransmission"]
    BAL["Excitation Inhibition Balance"]
    LOW["Reduced SLC32A1 Expression"]
    HYPER["Network Hyperexcitability"]
    EXCITO["Excitotoxic Stress"]
    NEURD["Neurodegeneration Risk"]
    SLC -->|"encodes"| VGAT
    VGAT -->|"loads"| GABA
    VGAT -->|"loads"| GLY
    GABA -->|"fills"| VES
    GLY -->|"fills"| VES
    VES -->|"undergoes"| RELEASE
    RELEASE -->|"enables"| INHIB
    INHIB -->|"maintains"| BAL
    LOW -->|"reduces"| VGAT
    LOW -->|"weakens"| INHIB
    INHIB -->|"limits"| HYPER
    HYPER -->|"drives"| EXCITO
    EXCITO -->|"elevates"| NEURD

Outgoing (72)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:SLC32A1	data_in	dataset_row	0.00
autophagy pathway	participates_in	pathway	0.70
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Tumor	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Pyroptosis	therapeutic_target	disease	0.65
Necroptosis	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Apoptosis	therapeutic_target	pathway	0.60
Endothelial	therapeutic_target	cell_type	0.60
Neuron	therapeutic_target	cell_type	0.60
Astrocyte	therapeutic_target	cell_type	0.60
Necroptosis	expressed_in	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
Pyroptosis	expressed_in	pathway	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
NPY	associated_with	gene	0.60
PVALB	associated_with	gene	0.60
SLC17A7	associated_with	gene	0.60
SLC17A6	associated_with	gene	0.60
RNA	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
PYROPTOSIS	expressed_in	gene	0.60
App	therapeutic_target	protein	0.60
MAPK signaling	participates_in	pathway	0.60
GRIN2A	biomarker_for	gene	0.60
PVALB	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60
SST	associated_with	gene	0.60
GRIA2	associated_with	gene	0.60
SNAP25	associated_with	gene	0.60
SLC17A7	biomarker_for	gene	0.60
Rb	associated_with	protein	0.60
AND	biomarker_for	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
SYN2	biomarker_for	gene	0.60
SLC17A6	biomarker_for	gene	0.60
SLC12A5	biomarker_for	gene	0.60
GAD1	biomarker_for	gene	0.60
SYP	biomarker_for	gene	0.60
SNAP25	interacts_with	gene	0.60
SST	interacts_with	gene	0.60
CANCER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
T Cell	associated_with	cell_type	0.60

Incoming (45)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:SLC32A1	data_in	dataset_row	0.00
SLC17A7	biomarker_for	gene	0.60
SLC17A6	biomarker_for	gene	0.60
SLC12A5	biomarker_for	gene	0.60
SYN2	biomarker_for	gene	0.60
GAD1	biomarker_for	gene	0.60
SYP	biomarker_for	gene	0.60
GRIN2A	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60
GRIA2	associated_with	gene	0.60
GRIA2	interacts_with	gene	0.60
NPY	interacts_with	gene	0.60
PVALB	interacts_with	gene	0.60
SLC17A6	interacts_with	gene	0.60
SLC17A7	interacts_with	gene	0.60
AND	biomarker_for	gene	0.60
POSTN	targets	gene	0.60
MIRNAS	targets	gene	0.60
PVALB	biomarker_for	gene	0.60
GAD1	activates	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
INS	associated_with	gene	0.60
SLC17A7	associated_with	gene	0.60
SLC17A6	associated_with	gene	0.60
NPY	associated_with	gene	0.60
PVALB	associated_with	gene	0.60
GLUL	targets	gene	0.60
MAPK10	targets	gene	0.60
MAPT	targets	gene	0.60
GLUL	implicated_in	gene	0.60
MAPK10	implicated_in	gene	0.60
MAPT	implicated_in	gene	0.60
INS	interacts_with	gene	0.60
DEMENTIA	expressed_in	gene	0.60
HUB GENES	biomarker_for	gene	0.60
RNA	expressed_in	gene	0.60
PYROPTOSIS	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC32A1 in their description or question text

No additional research found