concept

PI3K/AKT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1936Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PI3K/AKT is a concept in neurodegeneration research. Key relationships include: regulates, inhibits, protects against. Associated with Alzheimer's disease, cerebral ischemia-reperfusion injury. Connected to 28 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	PI3K/AKT
Key Genes/Proteins	ABCB1, ACSL4, AKT, AMPK, ANGPT1, ANXA1
Related Diseases	Adult Dermatomyositis, Alzheimer's disease
Linked Hypotheses	2 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

PI3K/AKT/mTOR Signaling Pathway in Neurodegeneration

mechanism · 1115 words

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Pathway Diagram

graph TD
    PI3K_AKT["PI3K/AKT"]
    PI3K_AKT -->|"activates"| neuronal_survival["neuronal survival"]
    PI3K_AKT -->|"regulates"| synaptic_plasticity["synaptic plasticity"]
    PI3K_AKT -->|"activates"| oxidative_stress_resistance["oxidative stress resistance"]
    PI3K_AKT -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    PI3K_AKT -->|"regulates"| mTOR["mTOR"]
    PI3K_AKT -.protects against.-> oxidative_stress["oxidative stress"]
    PI3K_AKT -->|"regulates"| cell_proliferation["cell proliferation"]
    PI3K_AKT -->|"regulates"| apoptosis["apoptosis"]
    PI3K_AKT -->|"regulates"| autophagy["autophagy"]
    NF2["NF2"] -->|"regulates"| PI3K_AKT
    Ginsenoside_Rg1["Ginsenoside Rg1"] -->|"activates"| PI3K_AKT
    acupuncture["acupuncture"] -->|"regulates"| PI3K_AKT
    CCL21["CCL21"] -->|"activates"| PI3K_AKT
    AMPK["AMPK"] -->|"interacts"| PI3K_AKT
    merlin["merlin"] -->|"regulates"| PI3K_AKT
    Rb1["Rb1"] -->|"regulates"| PI3K_AKT
    Ginsenoside_Rb1["Ginsenoside Rb1"] -->|"activates"| PI3K_AKT
    THBS2["THBS2"] -->|"regulates"| PI3K_AKT

Outgoing (274)

Target	Relation	Type	Str
Cancer	activates	disease	0.95
ischemic stroke	regulates	disease	0.95
Aerobic Glycolysis	promotes	process	0.95
NRF2	activates	protein	0.95
Renal Tubular Epithelial Cell Apoptosis	mediates	process	0.92
osteoblast pyroptosis	inhibits	process	0.92
Lipid Metabolism	regulates	process	0.90
cell proliferation	promotes	process	0.90
Cardiomyocyte apoptosis	inhibits	process	0.90
GLUT1	phosphorylates	protein	0.90
Proteostasis	regulates	process	0.90
depression	therapeutic_target	disease	0.90
PFKFB3	phosphorylates	gene	0.90
cell migration	promotes	process	0.90
cell invasion	promotes	process	0.90
glucose metabolism	regulates	process	0.90
Cellular Survival	regulates	process	0.90
PKM2	phosphorylates	protein	0.90
Polystyrene Microplastics	inhibits	compound	0.90
Programmed Cell Death	regulates	process	0.90
HK2	phosphorylates	protein	0.90
Inflammation	regulates	process	0.90
Hemorrhagic Stroke	implicated_in	disease	0.90
MTOR	activates	gene	0.90
Autophagy	regulates	process	0.90
SLC2A1	phosphorylates	gene	0.90
Apoptosis	inhibits	process	0.88
APOPTOSIS	regulates	process	0.88
emotion-related brain regions	expressed_in	brain_region	0.88
Dermatomyositis	upregulates	disease	0.88
PENTOSE PHOSPHATE PATHWAY	regulates	entity	0.85
Neuronal Survival	activates	process	0.85
MTOR	regulates	gene	0.85
MYC	regulates	gene	0.85
HIF1A	regulates	gene	0.85
Neurodegeneration	modulates	disease	0.85
Neural Regeneration	activates	process	0.85
Homeostasis	associated_with	process	0.85
HIF1A	activates	gene	0.85
oxidative stress	modulates	process	0.85
MTORC1	regulates	protein	0.85
GSK3	regulates	protein	0.85
Cytokines	regulates	compound	0.85
FOXO	regulates	protein	0.85
neurogenesis	regulates	process	0.85
Adult Dermatomyositis	upregulates	disease	0.85
Lithium Neurotoxicity	involved_in	process	0.85
rheumatoid arthritis	associated_with	disease	0.85
mTOR	activates	protein	0.85
VASCULAR BARRIER FUNCTION	promotes	process	0.85

Incoming (1662)

Source	Relation	Type	Str
NEUROINFLAMMATION	activates	gene	1.00
TNF	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
Neuroinflammation	activates	disease	1.00
INFLAMMATION	activates	gene	1.00
TNF-Α	activates	gene	1.00
Inflammation	activates	disease	1.00
DNA	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
Als	inhibits	disease	1.00
Tumor	therapeutic_target	disease	1.00
AUTOPHAGY	inhibits	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
LC3	activates	gene	1.00
NF-ΚB	regulates	gene	1.00
CANCER	regulates	gene	1.00
INFLAMMATION	inhibits	gene	1.00
NRF2	activates	gene	1.00
Cancer	regulates	disease	1.00
Inflammation	inhibits	disease	1.00
BCL-2	therapeutic_target	gene	1.00
Als	regulates	disease	1.00
BCL-2	activates	gene	1.00
PI3K	activates	gene	1.00
Inflammation	therapeutic_target	disease	1.00
EGFR	therapeutic_target	gene	1.00
Breast Cancer	therapeutic_target	disease	1.00
MTOR	inhibits	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
AKT	regulates	gene	1.00
NF-ΚB	inhibits	gene	1.00
APOPTOSIS	activates	gene	1.00
AKT	activates	gene	1.00
GENES	regulates	gene	1.00
GENES	therapeutic_target	gene	1.00
INFLAMMATION	regulates	gene	1.00
Aging	activates	disease	1.00
NF-ΚB	activates	gene	1.00
BAX	activates	gene	1.00
PI3K	regulates	gene	1.00
ERK	activates	gene	1.00
Inflammation	regulates	disease	1.00
MTOR	activates	gene	1.00
PI3K	associated_with	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
HIF	activates	gene	1.00
Alzheimer	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
MTOR	regulates	gene	1.00
CANCER	activates	gene	1.00

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CD44-Mediated Src/PI3K/Akt Signaling Cascade	0.470	neuroinflammation	What molecular mechanisms mediate SPP1-i

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PI3K/AKT in their description or question text

No additional research found