pathway

Synaptic Transmission

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Synaptic Transmission: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

248Connections

1Hypotheses

1Analyses

15Outgoing

50Incoming

0Experiments

2Debates

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🔀 Pathway Info

Name	Synaptic Transmission
Key Genes/Proteins	ACHE, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, AMPA RECEPTOR, AMYLOID
Related Diseases	Aging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
Linked Hypotheses	1 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

Synaptic Transmission

mechanism · 2440 words

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Pathway Diagram

graph TD
    MIRO1["MIRO1"] -->|"therapeutic target"| Synaptic_Transmission["Synaptic Transmission"]
    ERK["ERK"] -.->|"inhibits"| Synaptic_Transmission["Synaptic Transmission"]
    GAP43["GAP43"] -->|"interacts"| Synaptic_Transmission["Synaptic Transmission"]
    ERBB4["ERBB4"] -->|"activates"| Synaptic_Transmission["Synaptic Transmission"]
    style Synaptic_Transmission fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
NEURONS	treats	cell_type	0.65
Proteins	activates	protein	0.50
Proteins	interacts_with	protein	0.50
Proteins	regulates	protein	0.50
Proteins	associated_with	protein	0.50
CA3	associated_with	brain_region	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
CA1	associated_with	brain_region	0.50
PREFRONTAL CORTEX	activates	concept	0.50
INTERNEURONS	activates	concept	0.50
CELL SURVIVAL	regulates	concept	0.50
GLUTAMATE	regulates	concept	0.50
RETINA	associated_with	brain_region	0.50
PREFRONTAL CORTEX	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45

Incoming (233)

Source	Relation	Type	Str
Chr2	inhibits	protein	0.95
BDNF	modulates	protein	0.90
Purinergic Receptor Type 2	mediates	receptor	0.90
Astrocytes	regulates	cell_type	0.90
CNR1	regulates	protein	0.90
Cytoskeleton	regulates	pathway	0.90
Astrocytes	modulates	cell_type	0.90
Calcium Homeostasis	regulates	process	0.90
Astrocytes	mediates	cell_type	0.85
LRRK2	associated_with	gene	0.85
Alzheimer'S Disease	associated_with	disease	0.85
BIN1	modulates	gene	0.85
SNCA	involved_in	gene	0.85
Gaba-B Receptor	regulates	receptor	0.85
NPY	involved_in	gene	0.85
DLG4	involved_in	protein	0.80
PINK1	regulates	gene	0.80
BDNF	enhances	gene	0.80
BIN1	associated_with	protein	0.75
CPLX2	involved_in	gene	0.75
EZH2	inhibits	enzyme	0.70
BDNF	regulates	gene	0.70
BRD4	regulates	gene	0.70
BIN1	regulates	gene	0.65
TAU	regulates	protein	0.65
BIN1	transports	gene	0.65
PARKINSON	regulates	gene	0.60
ALPHA-SYNUCLEIN	associated_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
AND	inhibits	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
AND	associated_with	gene	0.60
PARKINSON	impairs	disease	0.60
PARKINSON'S	impairs	disease	0.60
BASAL GANGLIA	associated_with	brain_region	0.60
PARKINSON'S DISEASE	associated_with	disease	0.60
PARKIN	regulates	gene	0.60
STING	mediates	gene	0.60
BDNF	mediates	gene	0.60
PARKIN	impairs	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
GLUTAMATERGIC	regulates	cell_type	0.60
MICROGLIA	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
EPILEPSY	inhibits	gene	0.60
ASTROCYTES	regulates	gene	0.60
ASTROCYTE	regulates	gene	0.60
OGT	regulates	gene	0.60
AND	regulates	gene	0.60
DEPRESSION	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Pharmacological EZH2 Inhibition Resets Polycomb-Mediated Rep	0.680	neurodegeneration	epigenetic reprogramming aging neurons

Mentioning Analyses (1)

Scientific analyses that reference this entity

Investigate mechanisms of epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Investigate mechanisms of epigenetic reprogramming in aging neurons [TARGET_ART

closed · Rounds: 0 · Score: 0.50 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons

closed · Rounds: 0 · Score: 0.56 · 2026-04-21

Related Research

Hypotheses and analyses mentioning Synaptic Transmission in their description or question text

No additional research found