cell 1,411 words KG: ent-gene-8cd44c77
Contents

Neuropeptide Y (NPY) Neurons (Arcuate)

🔬 Protein Info
Gene Symbolent-gene-8cd44c77
NPY/AgRP neuronsThe primary orexigenic population
NPY/GABA neuronsCo-release GABA as a neurotransmitter
NPY/POMC neuronsRare subpopulation with mixed phenotype
Projecting neuronsLong-range projections to forebrain and brainstem
Somatic sizeMedium-sized neurons (15-25 μm diameter)
Dendritic architectureExtensive dendritic trees for signal integration
Axonal projectionsDense terminal fields in hypothalamic and limbic regions
Synaptic specializationsBoth excitatory and inhibitory synapses
Prepro-NPY geneEncodes the NPY precursor protein (prepro-NPY)
AgRP geneCo-expressed with NPY, encodes agouti-related protein
PCSK1Proprotein convertase for peptide processing
Secretogranin IIPrecursor for secretogranins and NPY family peptides
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (5)

Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
...
Score: 0.68

Related Analyses (10)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-8cd44c77 data_in benchmark_ot_ad_answer_key:NPY
benchmark_ot_ad_answer_key:NPY data_in ent-gene-8cd44c77

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