gene

POMC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about POMC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

185Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

POMC is a gene implicated in neurodegeneration research. Key relationships include: expressed in, regulates, activates. Associated with ALS, Aging, Als. Connected to 48 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	POMC
Full Name	Proopiomelanocortin
Chromosome	2p23.3
Function	encodes a precursor protein that is cleaved to produce multiple biologically active peptides, including α-melanocyte stimulating hormone (α-MSH), β-endorphin, and adrenocorticotropic hormone (ACTH).
Primary Expression	the pituitary gland, hypothalamus, and skin melanocytes [@pomc]
Amino Acids	267 aa
Exons	3 exons encoding the 267-amino acid POMC precursor
Pathways	Amyloid, Cholesterol, Cholesterol Metabolism, Er Stress, Immune Response
GeneCards	POMC
Human Protein Atlas	POMC
Chromosomal location	2p23.3
Gene length	Approximately 8.5 kb
Promoter	Contains response elements for glucocorticoids, leptin, and inflammatory cytokines
Leptin	Positively regulates POMC transcription in hypothalamic neurons
Glucocorticoids	Suppress POMC expression in pituitary corticotrophs
Associated Diseases	Alopecia Areata, ALS, Alzheimer, Cancer, Hypertension, Ptsd
Interactions	AIF1, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID, AND
KG Connections	185 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    POMC["POMC"]
    Tumor{"Tumor"}
    POMC -->|"expressed in"| Tumor
    Als{"Als"}
    POMC -->|"activates"| Als
    Aging{"Aging"}
    POMC -->|"regulates"| Aging
    Ms{"Ms"}
    POMC -->|"regulates"| Ms
    Obesity{"Obesity"}
    POMC -->|"regulates"| Obesity
    POMC -->|"regulates"| Als
    ALS{"ALS"}
    POMC -->|"activates"| ALS
    POMC -->|"regulates"| ALS
    POMC -->|"activates"| Obesity
    Inflammation{"Inflammation"}
    POMC -->|"activates"| Inflammation
    FOOD_INTAKE["FOOD_INTAKE"]
    POMC -->|"inhibits"| FOOD_INTAKE
    CRHR1["CRHR1"]
    POMC -->|"expressed in"| CRHR1
    ARC["ARC"]
    ARC -->|"produces"| POMC
    CRH["CRH"]
    CRH -->|"expressed in"| POMC
    AVP["AVP"]
    AVP -->|"expressed in"| POMC
    CRH -->|"regulates"| POMC
    CRHR1 -->|"expressed in"| POMC
    NPY["NPY"]
    NPY -->|"regulates"| POMC
    NTS["NTS"]
    NTS -->|"regulates"| POMC
    AND["AND"]
    AND -->|"expressed in"| POMC
    TNF["TNF"]
    TNF -->|"expressed in"| POMC
    AND -->|"regulates"| POMC
    STAT3["STAT3"]
    STAT3 -->|"interacts with"| POMC
    style POMC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (119)

Target	Relation	Type	Str
ACTH	associated_with	protein	0.90
Food Intake	inhibits	process	0.88
Alopecia Areata	associated_with	disease	0.85
Obesity	regulates	disease	0.75
Aging	regulates	disease	0.75
Immune Response	activates	pathway	0.70
Inflammation	activates	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	activates	disease	0.65
Obesity	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Als	regulates	disease	0.65
Depression	activates	disease	0.65
Stroke	activates	disease	0.65
Parkinson	activates	disease	0.65
Anxiety	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Diabetes	activates	disease	0.65
ALS	regulates	disease	0.65
ALS	inhibits	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ptsd	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
FOOD_INTAKE	inhibits	phenotype	0.64
APP/PS1	activates	gene	0.60
PTGS1	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
Cholesterol Metabolism	activates	pathway	0.60
Amyloid	activates	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
CRH	expressed_in	gene	0.60
AND	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
AND	expressed_in	gene	0.60
NR3C2	expressed_in	gene	0.60
App	regulates	protein	0.60
neurons	expressed_in	cell_type	0.60
ALS	associated_with	disease	0.60
Neurogenesis	activates	pathway	0.60
Neuron	activates	cell_type	0.60
Insulin	activates	protein	0.60
Interleukin	activates	protein	0.60
UCP2	activates	gene	0.60

Incoming (66)

Source	Relation	Type	Str
ARC	produces	brain_region	0.72
DNA	interacts_with	gene	0.60
NR3C1	expressed_in	entity	0.60
SQSTM1	regulates	gene	0.60
ESR1	expressed_in	entity	0.60
ESR2	expressed_in	entity	0.60
LC3B	activates	gene	0.60
STAT3	regulates	gene	0.60
P62	regulates	gene	0.60
NTS	regulates	gene	0.60
ARC	activates	gene	0.60
CAMKK2	activates	gene	0.60
COX4I1	activates	gene	0.60
GFAP	activates	gene	0.60
IBA1	activates	gene	0.60
LAMP2	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
NEFM	activates	gene	0.60
NFM	activates	gene	0.60
NPY	activates	gene	0.60
BECN1	interacts_with	gene	0.60
AIF1	activates	gene	0.60
CRHR1	expressed_in	gene	0.60
NPY	regulates	gene	0.60
AMPK	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
APP/PS1	activates	gene	0.60
PTGS1	activates	gene	0.60
LDL	activates	gene	0.60
PKD2	interacts_with	gene	0.60
TNF	expressed_in	gene	0.60
CRH	interacts_with	gene	0.60
NGF	activates	gene	0.60
PPARG	activates	gene	0.60
PRKAA1	activates	gene	0.60
LDLR	activates	gene	0.60
APP	activates	gene	0.60
NR3C1	associated_with	gene	0.60
AND	interacts_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GENES	activates	gene	0.60
STROKE	activates	gene	0.60
CRH	expressed_in	gene	0.60
AVP	expressed_in	gene	0.60
CRH	regulates	gene	0.60
JUN	activates	gene	0.60
AVP	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
CRH	associated_with	gene	0.60
AVP	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning POMC in their description or question text

No additional research found

POMC

Understanding Entity Pages

Summary

Wiki Pages (17)

POMC — Proopiomelanocortin

Arcuate Nucleus POMC Neurons

Proopiomelanocortin (POMC) Neurons

Arcuate POMC Neurons

POMC (Proopiomelanocortin) Neurons

Hypothalamic POMC Neurons

Arcuate Nucleus POMC Neurons

Hypothalamic Arcuate POMC Neurons

Arcuate Nucleus POMC Neurons

Hypothalamic POMC Neurons in Prader-Willi Syndrome

Hypothalamic POMC Neurons in Prader-Willi Syndrome

POMC Neurons in Hypothalamus

Arcuate Nucleus POMC in Energy Balance

POMC Neurons - Expanded

Arcuate Nucleus POMC Neurons - Expanded

Arcuate Nucleus POMC Neurons

Arcuate Nucleus POMC Neurons

Pathway Diagram

Outgoing (119)

Incoming (66)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)

Debates (0)

Related Research