brain_region

ARC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

248Connections

30Hypotheses

0Analyses

50Outgoing

50Incoming

10Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🔮 Predicted Structure: ARC — AlphaFold Q7Z594 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ARC["ARC"] -->|"regulates"| Aging["Aging"]
    ARC["ARC"] -->|"produces"| NPY["NPY"]
    ARC["ARC"] -->|"produces"| AGRP["AGRP"]
    ARC["ARC"] -->|"produces"| POMC["POMC"]
    ARC["ARC"] -->|"therapeutic target"| Oxidative_Stress["Oxidative Stress"]
    ARC["ARC"] -->|"regulates"| SYNAPSE["SYNAPSE"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| ARC["ARC"]
    FOS["FOS"] -->|"activates"| ARC["ARC"]
    STAT3["STAT3"] -->|"activates"| ARC["ARC"]
    BDNF["BDNF"] -->|"activates"| ARC["ARC"]
    style ARC fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (175)

Target	Relation	Type	Str
neurotrophin signaling	participates_in	pathway	0.75
Aging	regulates	disease	0.75
BDNF	activates	gene	0.75
FOS	activates	gene	0.75
synaptic plasticity	participates_in	pathway	0.75
POMC	produces	protein	0.72
AGRP	produces	protein	0.72
NPY	produces	protein	0.72
SYNAPSE	regulates	gene	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
Als	degrades	disease	0.65
Ms	activates	disease	0.65
Aging	activates	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
CREB1	activates	gene	0.65
Als	interacts_with	disease	0.65
Obesity	regulates	disease	0.65
ALS	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Senescence	activates	disease	0.65
Macular Degeneration	associated_with	disease	0.65
Retinopathy	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Senescence	therapeutic_target	disease	0.65
Glaucoma	associated_with	disease	0.65
Obesity	activates	disease	0.65
Anxiety	activates	disease	0.65
Senescence	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
ALS	interacts_with	disease	0.65
Hypertension	expressed_in	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	associated_with	disease	0.65
Als	regulates	disease	0.65
Depression	regulates	disease	0.65
ALS	activates	disease	0.65
Ferroptosis	inhibits	disease	0.65
Aging	contributes_to	disease	0.65
Als	activates	disease	0.65
CREB	activates	gene	0.65
Neuron	interacts_with	cell_type	0.60
Stem Cell	activates	cell_type	0.60
FERROPTOSIS	inhibits	gene	0.60
thalamus	expressed_in	brain_region	0.60
ferroptosis	causes	process	0.60
ferroptosis	associated_with	process	0.60

Incoming (73)

Source	Relation	Type	Str
OXIDATIVE STRESS	therapeutic_target	gene	0.70
STAT3	activates	gene	0.70
BDNF	activates	gene	0.70
FOS	activates	gene	0.70
FOXO3	therapeutic_target	gene	0.60
NR4A1	activates	gene	0.60
JUN	activates	gene	0.60
FOS	regulates	gene	0.60
PLIN2	activates	gene	0.60
MMP2	activates	gene	0.60
SIRT1	therapeutic_target	gene	0.60
CD8	activates	gene	0.60
CD4	activates	gene	0.60
AKT	associated_with	gene	0.60
AGING	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
CRH	regulates	gene	0.60
AND	regulates	gene	0.60
POMC	regulates	gene	0.60
NTS	interacts_with	gene	0.60
AKT	activates	gene	0.60
NRF2	activates	gene	0.60
IFNG	activates	gene	0.60
AND	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
COMPLEMENT	regulates	gene	0.60
DEPRESSION	regulates	gene	0.60
NESTIN	inhibits	gene	0.60
PIK3R3	activates	gene	0.60
AKT	regulates	gene	0.60
PI3K	interacts_with	gene	0.60
NPY	regulates	gene	0.60
PKC	regulates	gene	0.60
CALCINEURIN	regulates	gene	0.60
SNAP25	regulates	gene	0.60
GEPHYRIN	regulates	gene	0.60
C1Q	regulates	gene	0.60
AIF1	activates	gene	0.60
ROS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AMPK	therapeutic_target	gene	0.60
CREB	activates	gene	0.60
C-JUN	activates	gene	0.60
ERK	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
C-FOS	activates	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hierarchical Phase Separation with Scaffold Cores	0.630	neurodegeneration	What determines the specificity of RNA-p
Sticker-Spacer Phase Behavior Determines Recruitment Hierarc	0.570	molecular biology	What physicochemical properties determin
OPA1-Mediated Cristae Architecture Vulnerability	0.490	neurodegeneration	What determines the specificity of TDP-4
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-

[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-
[Archived Hypothesis]	0.300	-	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
GWAS of plasma NfL in East Asian cohort	exploratory	Alzheimer's disease	0.950	human patients - East Asian co	proposed	N/A
Endothelial CD2AP knockdown effects on memory in male mice	validation	Alzheimer's disease	0.900	male mice	proposed	N/A
C1q neutralization experiment	validation	perioperative neurocognitive d	0.900	rats	proposed	N/A
TREK-1 regulation of conventional outflow facility in mouse eyes	validation	ocular hypertension	0.900	mouse eyes	proposed	N/A
Microarray and single-cell RNA analysis of lipid metabolism genes	exploratory	idiopathic pulmonary fibrosis	0.850	human patients, mouse models	proposed	N/A
Neuroimmune modulation and Aβ clearance mechanisms	exploratory	Alzheimer's disease	0.820	Microglia and astrocytes	proposed	N/A
G3BP1-binding factor cooperativity in stress granule network regulatio	exploratory		0.800	cell culture systems with prot	proposed	N/A
CD2AP expression and cognitive decline in AD patients	exploratory	Alzheimer's disease	0.800	human patients	proposed	N/A
Activity-dependent PGC-1α transcriptional program analysis	exploratory	neurodevelopmental disorders	0.800	mouse cortical neurons	proposed	N/A
Competing endogenous RNA (ceRNA) network construction	exploratory	Alzheimer's disease	0.750	computational network analysis	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ARC in their description or question text

ARC

Understanding Entity Pages

Wiki Pages (21)

Kisspeptin Neurons (Expanded)

SMARCA2 (BRM)

ARC-IM Adaptive Neurostimulation for Parkinson's Disease

ARCH Venture Partners

MARCHF2 — Membrane-Associated RING-CH Finger 2

MARCHF2 Protein

SMARCA2 Protein (BAF155)

SMARCB1 — SWI/SNF Related Matrix Associated Actin Dependent Regulator of Chromatin Subfamily B Member 1

MARCHF1

MARCH7 Protein

SMARCAL1

SMARCA4

ARC Protein

Nucleus Robustus Arcuati (ARC) Dopaminergic Neurons

Arcuate Nucleus (ARC) Expanded

MARCH5 Gene

ARC-IM Adaptive Neurostimulation for PD

MARCH5 Protein

ARC Gene

Arcuate Nucleus (ARC) Neurons

MARCH7 — Membrane Associated Ring-CH Type Finger 7