concept

EXCITOTOXICITY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXCITOTOXICITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

346Connections

1Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

6Debates

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💡 Concept Info

Name	EXCITOTOXICITY
Key Genes/Proteins	AKT, AMPK, AMYLOID, AMYLOID-BETA, amyotrophic lateral sclerosis
Related Diseases	ALS, Alzheimer'S Disease, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Excitotoxicity in Neurodegeneration

mechanism · 4129 words

→

Pathway Diagram

graph TD
    EXCITOTOXICITY["EXCITOTOXICITY"]
    EXCITOTOXICITY -->|"causes"| Neurotoxicity["Neurotoxicity"]
    EXCITOTOXICITY -->|"causes"| STIM1["STIM1"]
    EXCITOTOXICITY -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    EXCITOTOXICITY -->|"inhibits"| FOXO3["FOXO3"]
    EXCITOTOXICITY -->|"activates"| NEURON["NEURON"]
    EXCITOTOXICITY -->|"activates"| STING["STING"]
    EXCITOTOXICITY -->|"promotes"| HIPPOCAMPUS["HIPPOCAMPUS"]
    EXCITOTOXICITY -->|"promotes"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    EXCITOTOXICITY -->|"regulates"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    glutamate_receptors["glutamate receptors"] -->|"causes"| EXCITOTOXICITY
    Glutamate["Glutamate"] -->|"causes"| EXCITOTOXICITY
    Glutamate_receptors["Glutamate receptors"] -->|"mediates"| EXCITOTOXICITY
    NAD_metabolism["NAD metabolism"] -->|"participates in"| EXCITOTOXICITY
    GLUTAMATE["GLUTAMATE"] -->|"causes"| EXCITOTOXICITY
    glutamate["glutamate"] -->|"causes"| EXCITOTOXICITY
    ginsenosides["ginsenosides"] -->|"inhibits"| EXCITOTOXICITY
    inflammation["inflammation"] -->|"causes"| EXCITOTOXICITY
    GLUTAMATE_RECEPTORS["GLUTAMATE_RECEPTORS"] -->|"causes"| EXCITOTOXICITY

Outgoing (158)

Target	Relation	Type	Str
Ischemic Stroke	contributes_to	disease	0.90
Calcium Overload	associated_with	process	0.90
Motor Neuron Death	causes	process	0.90
Stroke	contributes_to	disease	0.90
Neurotoxicity	causes	process	0.90
Motor Neuron Degeneration	contributes_to	phenotype	0.85
CELL DEATH	activates	phenotype	0.70
Ferroptosis	activates	pathway	0.70
ERK	regulates	gene	0.70
Amyotrophic lateral sclerosis	associated_with	disease	0.70
AXONAL DEGENERATION	activates	phenotype	0.65
NECROPTOSIS	regulates	phenotype	0.65
AMPK	activates	gene	0.65
FERROPTOSIS	activates	phenotype	0.65
FERROPTOSIS	causes	phenotype	0.65
FERROPTOSIS	inhibits	phenotype	0.65
FERROPTOSIS	targets	phenotype	0.65
UBIQUITIN	degrades	protein	0.65
NECROPTOSIS	activates	phenotype	0.65
STIM1	causes	protein	0.64
STIM1	activates	gene	0.60
neuroinflammation	associated_with	process	0.60
SST	activates	gene	0.60
MIRO1	associated_with	gene	0.60
oxidative stress	regulates	process	0.60
TRKB	associated_with	gene	0.60
TET2	activates	gene	0.55
ULK1	activates	gene	0.55
VGLUT1	inhibits	gene	0.55
HK2	activates	gene	0.55
TFEB	activates	gene	0.55
SPINAL CORD	associated_with	brain_region	0.55
PARKINSON'S DISEASE	participates_in	disease	0.55
GLUTAMATE	co_discussed	entity	0.50
RIPK3	co_discussed	entity	0.50
LOCUS COERULEUS	co_discussed	entity	0.50
OLIGODENDROCYTE	co_discussed	entity	0.50
OLIGODENDROCYTES	co_discussed	entity	0.50
MITOCHONDRIAL DYSFUNCTION	associated_with	process	0.50
NEURON	regulates	cell_type	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
CORTEX	associated_with	brain_region	0.50
FOXO3	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
NEURONS	co_discussed	entity	0.50
PARKINSON'S	co_discussed	entity	0.50
MS	co_discussed	entity	0.50
NEURON	causes	entity	0.50
RIPK1	co_discussed	entity	0.50
FERROPTOSIS	co_discussed	entity	0.50

Incoming (188)

Source	Relation	Type	Str
NPY	protects_against	protein	0.95
39602529	were neuroprotective against	paper	0.90
glutamate receptors	causes	protein	0.90
Glutamate	causes	entity	0.90
Glutamate receptors	mediates	receptor	0.90
Astrocyte	mediates	cell_type	0.90
Oligodendrocyte	mediates	cell_type	0.90
Glutamate Receptor Accumulation	causes	mechanism	0.85
Astrocytes	contributes_to	cell_type	0.85
Glutamate Receptor Accumulation	contributes_to	process	0.85
CYTOKINES	associated_with	protein	0.85
NAD metabolism	participates_in	biological_process	0.80
SOD1	mediates	protein	0.80
NPY	alleviates	gene	0.80
HMGCR	inhibits	gene	0.80
GLUTAMATE	causes	drug	0.72
inflammation	causes	process	0.70
GABA	protects_against	phenotype	0.70
SLC7A11	causes	protein	0.70
GABA	inhibits	phenotype	0.70
ginsenosides	inhibits	drug	0.70
SYNAPTIC PLASTICITY	causes	phenotype	0.70
TREM2 upregulation in DAM cells	causes	mechanism	0.70
NPTX2 downregulation	causes	mechanism	0.70
glutamate	causes	protein	0.70
VGLUT1 terminals	vulnerable_to	cell_type	0.70
glutamate_receptors	causes	protein	0.68
GLUTAMATE_RECEPTORS	causes	protein	0.68
LOCUS COERULEUS	causes	brain_region	0.65
STROKE	causes	disease	0.65
ALZHEIMER'S DISEASE	implicated_in	disease	0.65
KYNURENINE PATHWAY	activates	pathway	0.65
BDNF	activates	gene	0.65
ASTROCYTES	exacerbates	cell_type	0.65
ASTROCYTE	causes	cell_type	0.65
ROS	inhibits	phenotype	0.65
SLC1A2	protects_against	gene	0.60
SLC1A3	protects_against	gene	0.60
AKT	activates	gene	0.58
ALZHEIMER'S DISEASE	activates	disease	0.58
autophagy	activates	pathway	0.55
GABA	expressed_in	phenotype	0.55
GLUTAMATE	associated_with	phenotype	0.55
AUTOPHAGY	co_discussed	entity	0.50
GLUTAMATE	mediates	entity	0.50
oxidative stress	activates	phenotype	0.50
Hippocampus	activates	entity	0.50
ISCHEMIA	associated_with	disease	0.50
Tauopathy	inhibits	disease	0.50
Neurodegenerative Diseases	associated_with	disease	0.50