Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CENTRAL PRECOCIOUS PUBERTY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CENTRAL PRECOCIOUS PUBERTY |
graph TD
CENTRAL_PRECOCIOUS_PUBERTY[CENTRAL PRECOCIOUS PUBERTY]
Hypothalamic_Pituitary_Gonadal[Hypothalamic-Pituitary-Gonadal Axis] -->|involved_in| CENTRAL_PRECOCIOUS_PUBERTY
MKRN3[MKRN3] -->|risk_factor_for| CENTRAL_PRECOCIOUS_PUBERTY
DLK1[DLK1] -->|risk_factor_for| CENTRAL_PRECOCIOUS_PUBERTY
KISS1[KISS1] -->|causes| CENTRAL_PRECOCIOUS_PUBERTY
KISS1R[KISS1R] -->|causes| CENTRAL_PRECOCIOUS_PUBERTY
Maternal_Age_At_Menarche[Maternal Age At Menarche] -->|risk_factor_for| CENTRAL_PRECOCIOUS_PUBERTY
DNA_Methylation[DNA Methylation] -->|mediates| CENTRAL_PRECOCIOUS_PUBERTY
Histone_Posttranslational_Modi[Histone Posttranslational Modifications] -->|mediates| CENTRAL_PRECOCIOUS_PUBERTY
Noncoding_Ribonucleic_Acids[Noncoding Ribonucleic Acids] -->|mediates| CENTRAL_PRECOCIOUS_PUBERTY
GABRA1[GABRA1] -->|involved_in| CENTRAL_PRECOCIOUS_PUBERTY| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| MKRN3 | risk_factor_for | gene | 0.90 |
| Hypothalamic-Pituitary-Gonadal Axis | involved_in | pathway | 0.90 |
| DLK1 | risk_factor_for | gene | 0.85 |
| KISS1R | causes | gene | 0.85 |
| KISS1 | causes | gene | 0.85 |
| Maternal Age At Menarche | risk_factor_for | phenotype | 0.80 |
| Maternal age at menarche | associated_with | phenotype | 0.80 |
| DNA Methylation | mediates | mechanism | 0.75 |
| Histone Posttranslational Modifications | mediates | mechanism | 0.75 |
| Noncoding Ribonucleic Acids | mediates | mechanism | 0.75 |
| GABRA1 | involved_in | gene | 0.70 |
| LIN28B | contributes_to | gene | 0.70 |
| TAC3 | contributes_to | gene | 0.70 |
| TACR3 | contributes_to | gene | 0.70 |
| LIN28B | implicated_in | gene | 0.70 |
| TAC3 | implicated_in | gene | 0.70 |
| TACR3 | implicated_in | gene | 0.70 |
| LIN28B | involved_in | gene | 0.70 |
| TAC3 | involved_in | gene | 0.70 |
| TACR3 | involved_in | gene | 0.70 |
| NPY | implicated_in | gene | 0.65 |
| GABRA1 | implicated_in | gene | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CENTRAL PRECOCIOUS PUBERTY in their description or question text
No additional research found