gene

SST

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SST: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

459Connections

26Hypotheses

2Analyses

50Outgoing

50Incoming

11Experiments

2Debates

Summary

SST is a gene implicated in neurodegeneration research. Key relationships include: inhibits, therapeutic target, implicated in. Associated with Alzheimer's disease, Depression, Ms. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SST
Chromosome	3q28
Protein Type	Ligand
Target Class	Ligand
Function	The SST gene encodes preprosomatostatin, which is processed to somatostatin-14 (the major form in the brain) and somatostatin-28 (predominant in the gut).
Mechanism of Action	Somatostatin is a peptide neurotransmitter that modulates neuronal signaling by inhibiting hormone release and neuronal excitability, with emerging evidence suggesting its potential neuroprotective role in neurodegenerative processes through regulation of inflammatory responses and synaptic plasticity. In neurodegeneration contexts, SST receptors may serve as modulators of neuroinflammatory cascades and potentially mitigate progressive neuronal damage through receptor-mediated signaling mechanisms.
Druggability	Low (0.41)
Clinical Stage	Approved
Amino Acids	14 aa
Pathways	Amyloid, affective empathy, gamma_oscillation, neuropeptide signaling, sleep-dependent growth hormone
UniProt ID	P61278
Ensembl ID	ENSG00000136744
GeneCards	SST
Human Protein Atlas	SST
Morphology	Lamp5 Lhx6 neuron (source: Cell Ontology)
Associated Diseases	Als, Alzheimer, alzheimer_s_disease, Alzheimer's disease
Known Drugs/Compounds	Octreotide, Lanreotide
Interactions	Actin, Albumin, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-Β PLAQUES
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Closed-loop transcranial focused ultrasound target Closed-loop transcranial focused ultrasound target Closed-loop focused ultrasound targeting EC-II SST (+11 more)
KG Connections	457 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SST — AlphaFold P61278 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SST["SST"]
    Alzheimer_s_disease{"Alzheimer's disease"}
    SST -->|"therapeutic target"| Alzheimer_s_disease
    gamma_oscillation(["gamma_oscillation"])
    SST -->|"regulates"| gamma_oscillation
    Ms{"Ms"}
    SST -->|"inhibits"| Ms
    Depression{"Depression"}
    SST -->|"inhibits"| Depression
    MMP3["MMP3"]
    SST -->|"inhibits"| MMP3
    Synaptic_Plasticity(["Synaptic Plasticity"])
    SST -->|"inhibits"| Synaptic_Plasticity
    Long_Term_Potentiation(["Long-Term Potentiation"])
    SST -->|"inhibits"| Long_Term_Potentiation
    MMP9["MMP9"]
    SST -->|"inhibits"| MMP9
    SST -->|"implicated in"| Alzheimer_s_disease
    neurodegeneration["neurodegeneration"]
    SST -->|"implicated in"| neurodegeneration
    h_bdbd2120["h-bdbd2120"]
    h_bdbd2120 -->|"therapeutic target"| SST
    h_bdbd2120 -->|"targets"| SST
    MMP9 -->|"inhibits"| SST
    style SST fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (295)

Target	Relation	Type	Str
Temporal Lobe Epilepsy	associated_with	disease	0.90
interneurons	regulates	cell_type	0.90
neurons	expressed_in	cell_type	0.90
cortex	expressed_in	brain_region	0.90
neurons	regulates	cell_type	0.90
PVB	interacts_with	gene	0.85
Alzheimer'S Disease	involved_in	disease	0.85
Tau Pathology	associated_with	biomarker	0.85
theta_oscillation	generates	pathway	0.82
interneurons	associated_with	cell_type	0.80
neurodegeneration	activates	disease	0.80
neurodegeneration	protects_against	disease	0.80
GABAergic neurons	associated_with	cell_type	0.80
diabetes	activates	disease	0.80
diabetes	protects_against	disease	0.80
thalamus	expressed_in	brain_region	0.80
neurons	inhibits	cell_type	0.80
interneurons	expressed_in	cell_type	0.80
interneurons	interacts_with	cell_type	0.80
neurons	associated_with	cell_type	0.80
GABAergic neurons	expressed_in	cell_type	0.80
Alzheimer's disease	therapeutic_target	disease	0.76
Pvalb	associated_with	cell_type	0.75
GABAergic interneuron networks	participates_in	pathway	0.70
Alzheimer's disease	associated_with	disease	0.70
neural stem cells	associated_with	cell_type	0.70
hippocampus	expressed_in	brain_region	0.70
gamma_oscillation	regulates	pathway	0.70
interneurons	inhibits	cell_type	0.70
neurons	interacts_with	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
Retinopathy	contributes_to	disease	0.65
Alzheimer	expressed_in	disease	0.65
Retinopathy	protects_against	disease	0.65
Epilepsy	associated_with	disease	0.65
Epilepsy	encodes	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Diabetes	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	activates	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Als	protects_against	disease	0.65
Alzheimer	regulates	disease	0.65
Addiction	biomarker_for	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Tumor	associated_with	disease	0.65

Incoming (164)

Source	Relation	Type	Str
h-f8316acf	targets	hypothesis	0.90
h-bdbd2120	targets	hypothesis	0.90
PVALB	associated_with	gene	0.90
h-var-ea70ada256	targets_gene	hypothesis	0.90
h-var-787aa9d1b4	targets_gene	hypothesis	0.90
h-var-b7e4505525	targets_gene	hypothesis	0.90
h-var-d33964b962	targets_gene	hypothesis	0.90
h-var-4d43a26612	targets_gene	hypothesis	0.90
h-var-e47f17ca3b	targets_gene	hypothesis	0.90
h-var-d749cd28cb	targets_gene	hypothesis	0.90
h-var-3b982ec3d2	targets_gene	hypothesis	0.90
h-var-d98a992599	targets_gene	hypothesis	0.90
h-var-55da4f915d	targets_gene	hypothesis	0.90
h-var-f110ef2e0a	targets_gene	hypothesis	0.90
PV	regulates	gene	0.70
PV	inhibits	gene	0.70
PV	expressed_in	gene	0.70
GABA	biomarker_for	gene	0.60
TAU	associated_with	gene	0.60
PENK	inhibits	gene	0.60
PVALB	treats	gene	0.60
BDNF	biomarker_for	gene	0.60
PV	activates	gene	0.60
PV	biomarker_for	gene	0.60
NPTX2	interacts_with	gene	0.60
RNA	expressed_in	gene	0.60
NEURON	associated_with	gene	0.60
ACC	regulates	gene	0.60
NEURODEGENERATION	contributes_to	gene	0.60
DIABETIC RETINOPATHY	contributes_to	gene	0.60
DIABETIC RETINOPATHY	protects_against	gene	0.60
SYNAPSE	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
GENES	regulates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
MKI67	associated_with	gene	0.60
MKI67	interacts_with	gene	0.60
INS	activates	gene	0.60
AND	expressed_in	gene	0.60
PARKINSON	inhibits	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
AND	regulates	gene	0.60
AND	activates	gene	0.60
ANXIETY	regulates	gene	0.60
GENES	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
AND	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60

Targeting Hypotheses (26)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound targeting EC-II	0.948	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.922	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2-ASM Crosstalk in Microglial Lysosomal Senescence	0.910	neurodegeneration	Gene expression changes in aging mouse b
Closed-loop focused ultrasound targeting EC-II SST interneur	0.900	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II SST interneurons to block t	0.896	Alzheimer's disease	Circuit-level neural dynamics in neurode

TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener	0.892	neurodegeneration	Gene expression changes in aging mouse b
Gamma entrainment therapy to restore hippocampal-cortical sy	0.851	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.845	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hypothesis 7: SST-SST1R/Gamma Entrainment-Enhanced Astrocyte	0.839	neurodegeneration	View
Real-time gamma-guided transcranial focused ultrasound targe	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Beta-frequency entrainment therapy targeting PV interneuron-	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial alternating current stimulation to	0.785	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	Alzheimer's disease	Circuit-level neural dynamics in neurode
Alpha-gamma cross-frequency coupling enhancement to restore	0.775	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.767	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2 Crosstalk and Synergistic Activation of Phagocytic Tra	0.730	neuroinflammation	What molecular mechanisms mediate SPP1-i
Cardiovascular-Neuroinflammation Crosstalk Interruption	0.587	Alzheimer's disease	Neuroinflammation and microglial priming
Gamma Entrainment Synergy: HBOT-Enhanced Cerebral Perfusion	0.583	neurodegeneration	View
Closed-loop tACS targeting EC-II somatostatin interneurons t	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
NAC + Ferrostatin-1 Combination for Peroxynitrite-Ferroptosi	0.530	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
Tripartite Synapse Cell Type-Nonautonomous Crosstalk: Coordi	0.510	neurodegeneration	Cell type vulnerability debate in Alzhei
Alpha-Beta Oscillation Coupling Enhances lncRNA-9969-Mediate	0.466	molecular neurobiology	View
Alpha-Beta Oscillation Entrainment Enhances lncRNA-9969-Medi	0.451	molecular neurobiology	View
Alpha-Theta Oscillation Modulation Enhances lncRNA-9969-Medi	0.451	molecular neurobiology	View
Theta-Gamma Coupling Modulates lncRNA-9969-Mediated Mitochon	0.438	molecular neurobiology	View

Mentioning Analyses (2)

Scientific analyses that reference this entity

Are interneuron oscillation deficits compensatory responses or primary pathologi

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.747

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 67 hypotheses Top: 1.000

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	0.00	human patients	proposed	N/A
Tet2 modulation in Aβ42-injured mouse hippocampal neurons	exploratory	Alzheimer's disease	0.900	0.00	primary mouse hippocampal neur	proposed	N/A
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$180,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Res	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Anatomical and neurochemical profiles of somatostatin-positive neurons in the mo [PMID:41796787]	Tomioka R, Kobayashi K, Song WJ	Neuroscience	2026	0
Subtype-Specific Roles of Anterior Cingulate Cortex Neurons in Pain-Induced Soci [PMID:41799202]	Wan X, Yan Z, Zhang Z, Liu X, Yang D, Zh	Theranostics	2026	0
A comparative analysis of pig-to-rhesus corneal xenotransplantation with various [PMID:41928466]	Lee SH, Yoon CH, Choi HJ, Lee HJ, Kang H	Korean J Ophthalmol	2026	0
Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestat [PMID:41779871]	Zhu H, Luo S, Liu C, Cheng Y, Ren Z, Mo	Science translational medicine	2026	0
Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: [PMID:41854733]	Liu K, Zhang XY, Wang YT, Wang R, Jin RH	Molecular neurobiology	2026	0
Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138]	Singer Y, Yitzhaky A, Hertzberg L	Alpha psychiatry	2026	0
Paracrine inhibition via G protein inwardly rectifying potassium channels regula [PMID:41824458]	Panzer JK, Lang AL, Levi NJ, Garcia PA,	Cell reports	2026	0
GADD45G operates as a pathological sensor orchestrating reactive gliosis and neu [PMID:40409253]	Shen T, Tai W, Jiang D, Ma S, Zhong X, Z	Neuron	2025	0
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheime [PMID:41035073]	Castanho I, Naderi Yeganeh P, Boix CA, M	Molecular neurodegeneration	2025	0
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974]	Dai L, Wang J, Meng L, Zhang X, Xiao T,	PLoS biology	2025	0
Molecular hallmarks of excitatory and inhibitory neuronal resilience and resista [PMID:39868232]	Castanho I, Yeganeh PN, Boix CA, Morgan	bioRxiv : the preprint server	2025	0
From stress to Alzheimer's: A circuit-based framework for prefrontal cognitive d [PMID:41115499]	Yi JH	Neuroscience letters	2025	0
Hippocampal Interneurons Shape Spatial Coding Alterations in Neurological Disord [PMID:40392508]	Ikebara JM, Jorge RS, Marinho LSR, Higa	Molecular neurobiology	2025	0
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing Res Rev	2024	0
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing research reviews	2024	0
Sterols and pentacyclic triterpenoids from nettle root: content and composition [PMID:36478201]	["Cegledi E", "Repaji\u0107 M", "Balbino	Journal of the science of food	2023	0
The association between the type of progesterone supplementation and miscarriage [PMID:37156908]	["Shaulov T", "Zanr\u00e9 N", "Phillips	Archives of gynecology and obs	2023	0
SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition. [PMID:38102334]	["Lai X", "Lui S", "Lam H", "Adachi Y",	NPJ precision oncology	2023	0

Debates (2)

Multi-agent debates referencing this entity

The debate raised whether SST/PV interneuron dysfunction represents adaptive com

closed · Rounds: 4 · Score: 0.76 · 2026-04-16

Analyze circuit-level changes in neurodegeneration using Allen Institute Neural

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning SST in their description or question text

SST

Understanding Entity Pages

Summary

Wiki Pages (6)

Cortical Ivy Cells

SST Protein — Somatostatin

Cortical SST Detector Cells

Somatostatin-Positive (SST+) Interneurons

SST Gene

Somatostatin (SST)

Pathway Diagram

Outgoing (295)

Incoming (164)

Targeting Hypotheses (26)

Mentioning Analyses (2)

Are interneuron oscillation deficits compensatory responses or primary pathologi

Circuit-level neural dynamics in neurodegeneration

Experiments (11)

Related Papers (20)

Debates (2)

The debate raised whether SST/PV interneuron dysfunction represents adaptive com

Analyze circuit-level changes in neurodegeneration using Allen Institute Neural

Related Research

TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration

Gamma entrainment therapy to restore hippocampal-cortical synchrony

Optogenetic restoration of hippocampal gamma oscillations via selective SST inte

Hypothesis 7: SST-SST1R/Gamma Entrainment-Enhanced Astrocyte Secretome

Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling f

Closed-loop transcranial alternating current stimulation to restore hippocampal-

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

Alpha-gamma cross-frequency coupling enhancement to restore thalamo-cortical mem

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

TREM2 Crosstalk and Synergistic Activation of Phagocytic Transcriptome

Cardiovascular-Neuroinflammation Crosstalk Interruption

Gamma Entrainment Synergy: HBOT-Enhanced Cerebral Perfusion Amplifies SST Intern

Closed-loop tACS targeting EC-II somatostatin interneurons to restore dendritic

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla