cell 1,192 words KG: ent-gene-8cd44c77
Contents

Hypothalamic NPY Neurons

🔬 Protein Info
Gene Symbolent-gene-8cd44c77
Morphologysuperior cervical ganglion NPY neuron (source: Cell Ontology)
Perifornical AreaA secondary population of NPY neurons located near the fornix, involved in feeding and arousal.
Dorsomedial Hypothalamus (DMH)Scattered NPY neurons involved in stress responses and energy balance.
Lateral Hypothalamus (LH)A smaller population that interfaces with orexin and melanin-concentrating hormone neurons.
Paraventricular Nucleus (PVN)Major projection that suppresses appetite through Y1 and Y5 receptors
Lateral HypothalamusModulates arousal and reward pathways
BrainstemProjects to nucleus tractus solitarius (NTS) and dorsal vagal complex
ThalamusTargets paraventricular nucleus of thalamus
Cortical AreasLess dense projections to prefrontal cortex and hippocampus
Agouti-Related Peptide (AgRP)Co-released with NPY, acts as an orexigenic (appetite-stimulating) peptide. AgRP is the most potent appetite-stimulating molecule known.
GalaninCo-expressed in some NPY neurons, involved in feeding and reproduction.
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Related Hypotheses (11)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Transcriptional Autophagy-Lysosome Coupling
Score: 0.90
APOE-Dependent Autophagy Restoration
Score: 0.86
Circadian Clock-Autophagy Synchronization
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
...
Score: 0.68

Related Analyses (14)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (6)

CLOCK/BMAL1 regulation of ICC autophagy in GERD model
exploratory · proposed · Score: 0.90
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · completed · Score: 0.90
AMPK knockdown validation experiment
exploratory · proposed · Score: 0.88
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-8cd44c77 data_in benchmark_ot_ad_answer_key:NPY
benchmark_ot_ad_answer_key:NPY data_in ent-gene-8cd44c77

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