protein

MBP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

441Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

MBP is a protein involved in neurodegeneration research. Key relationships include: activates, expressed in, inhibits. Associated with ALS, Aging, Als. Connected to 174 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	MBP
Full Name	Myelin Basic Protein
Chromosome	18q23
Function	Membrane compaction: MBP interacts with the cytoplasmic surface of the oligodendrocyte membrane, facilitating the tight apposition of myelin lamellae [6]
Primary Expression	a developmentally regulated manner, with different isoforms predominant at different stages of oligodendrocyte maturation and myelination
Subcellular Localization	and interaction with other myelin proteins. The 18.5 kDa isoform is the most abundant in adult human brain and is the pr
Molecular Weight	21.5 kDa
Amino Acids	197 aa
Exons	11
Pathways	MAPK
Ensembl ID	ENSG00000197971
GeneCards	MBP
Human Protein Atlas	MBP
Signal transduction	MBP can be phosphorylated, suggesting roles in cell signaling
Calcium homeostasis	MBP influences calcium signaling in oligodendrocytes
Associated Diseases	Als, Alzheimer, Alzheimer disease, dementia, Ms
Known Drugs/Compounds	metformin
Interactions	ACHE, ACSL4, AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
SciDEX Hypotheses	Myelin Breakdown-Amyloid Interaction Amplifies Cor
KG Connections	440 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MBP["MBP"]
    MBP -->|"activates"| Dementia["Dementia"]
    MBP -->|"activates"| Als["Als"]
    MBP -->|"activates"| Alzheimer["Alzheimer"]
    MBP -->|"activates"| Parkinson["Parkinson"]
    MBP -->|"activates"| Ms["Ms"]
    MBP -->|"activates"| Inflammation["Inflammation"]
    MBP -->|"regulates"| Stroke["Stroke"]
    MBP -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    MBP -->|"regulates"| Traumatic_Brain_Injury["Traumatic Brain Injury"]
    HSPA1A["HSPA1A"] -->|"activates"| MBP
    GFAP["GFAP"] -->|"inhibits"| MBP
    GAP43["GAP43"] -->|"inhibits"| MBP
    ELAVL3["ELAVL3"] -->|"inhibits"| MBP
    MANF["MANF"] -->|"inhibits"| MBP
    P38["P38"] -->|"regulates"| MBP
    CD36["CD36"] -->|"activates"| MBP
    TNF["TNF"] -->|"regulates"| MBP
    ACHE["ACHE"] -->|"activates"| MBP
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| MBP

Outgoing (275)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Myelin Degeneration	biomarker_for	phenotype	0.87
Als	expressed_in	disease	0.85
Inflammation	activates	disease	0.85
Microglia	upregulates	cell_type	0.85
Hypermyelination	involved_in	phenotype	0.85
Parkinson's Disease Dementia	upregulates	disease	0.80
oligodendrocytes	expressed_in	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
MOG	stabilizes	gene	0.70
SOD2	activates	gene	0.70
SYN1	stabilizes	gene	0.70
SQSTM1	activates	gene	0.70
OLIGODENDROCYTES	activates	cell_type	0.70
PINK1	activates	gene	0.70
MICROGLIA	inhibits	cell_type	0.70
MICROGLIA	degrades	cell_type	0.70
Autophagy	expressed_in	pathway	0.70
AUTOPHAGY	expressed_in	gene	0.70
Oxidative Stress	activates	pathway	0.70
MICROGLIA	activates	cell_type	0.70
Apoptosis	activates	pathway	0.70
Alzheimer	expressed_in	disease	0.65
OLIGODENDROCYTE	associated_with	concept	0.65
Traumatic Brain Injury	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Stroke	regulates	disease	0.65
Ms	activates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Dementia	expressed_in	disease	0.65
Ms	regulates	disease	0.65
Ms	inhibits	disease	0.65
Als	activates	disease	0.65
neuron	co_discussed	concept	0.65
Alzheimer	activates	disease	0.65
OLIG2	co_discussed	gene	0.65
MOG	regulates	gene	0.65
PARP1	co_discussed	gene	0.65
Parkinson	activates	disease	0.65
Als	associated_with	disease	0.65
MTOR	co_discussed	gene	0.65
Aging	activates	disease	0.65
MOG	associated_with	gene	0.65
oligodendrocyte	co_discussed	concept	0.65
Dementia	activates	disease	0.65
PLP1	associated_with	gene	0.65
Alzheimer's disease	expressed_in	disease	0.65
OLIGODENDROCYTES	produces	cell_type	0.65
Stroke	activates	disease	0.65
Ms	associated_with	disease	0.65

Incoming (166)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
Bpmc	downregulates	compound	0.85
BPMC	downregulates	gene	0.85
Transcranial near-infrared light	upregulates	compound	0.85
OLEA	upregulates	compound	0.80
INFLAMMATION	activates	gene	0.80
MYELIN	activates	gene	0.80
ATG7	activates	gene	0.70
CNP	activates	gene	0.70
BDNF	inhibits	gene	0.70
BIN1	biomarker_for	gene	0.70
CAT	activates	gene	0.70
LAMP1	associated_with	gene	0.70
BECN1	activates	gene	0.70
ATG5	activates	gene	0.70
OLIGODENDROCYTE	activates	gene	0.70
GENES	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
TNF	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
APOE	co_discussed	gene	0.65
LRRK2	co_discussed	gene	0.65
DEMYELINATION	regulates	phenotype	0.65
CLU	co_discussed	gene	0.65
BIN1	co_discussed	gene	0.65
TNF	regulates	gene	0.60
APP	degrades	gene	0.60
HMGB1	inhibits	gene	0.60
CAT	inhibits	gene	0.60
ERK	mediates	gene	0.60
OLIGODENDROCYTE	inhibits	gene	0.60
GFAP	co_discussed	gene	0.60
BIN1	associated_with	gene	0.60
CLU	regulates	gene	0.60
ASTROCYTE	inhibits	gene	0.60
CGAS	associated_with	gene	0.60
ASTROCYTE	associated_with	gene	0.60
STROKE	activates	gene	0.60
GAP43	inhibits	gene	0.60
MMP9	associated_with	gene	0.60
APP	causes	gene	0.60
AD	markers	gene	0.60
AΒ	co_discussed	gene	0.60
BPMC	inhibits	gene	0.60
MANF	inhibits	gene	0.60
ERK	activates	gene	0.60
MAG	expresses	gene	0.60
HSPA1A	activates	gene	0.60
GFAP	inhibits	gene	0.60
BDNF	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Myelin Breakdown-Amyloid Interaction Amplifies Cortical Agin	0.584	Alzheimer disease	Allen Mouse Brain Aging Atlas: cross-age

Mentioning Analyses (1)

Scientific analyses that reference this entity

Allen Mouse Brain Aging Atlas: cross-age gene expression analysis

neurodegeneration | 2026-04-23 | 8 hypotheses Top: 0.674

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease. [PMID:40399225]	Unknown	Neurotherapeutics : the journa	2025
Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease. [PMID:40399225]	Campagna, Jagodzinska, Wi, Zhu, Lee et a	Neurotherapeutics : the journa	2025
Amyloid fibrils of the myelin basic protein are an integral component of myelin [PMID:40781105]	Sysoev EI, Shenfeld AA, Belashova TA	Sci Rep	2025
β-asarone improves cognitive impairment and alleviates autophagy in mice with va [PMID:38039902]	Ning, Zhong, Wu, Wang, Hu et al.	Phytomedicine : international	2024
Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, [PMID:39023138]	Bagheri H, Friedman H, Hadwen A	Glia	2024
β-asarone improves cognitive impairment and alleviates autophagy in mice with va [PMID:38039902]	Unknown	Phytomedicine : international	2024
Myelin basic protein and index for neuro-Behçet's disease. [PMID:36907539]	Zhan H, Cheng L, Wang X	Clin Immunol	2023
The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Syst [PMID:34350544]	Whitfield, Barnhofer, Acabchuk, Cohen, L	Neuropsychology review	2022
Multiple sclerosis and myelin basic protein: insights into protein disorder and [PMID:34889995]	Martinsen V, Kursula P	Amino Acids	2022
The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Syst [PMID:34350544]	Unknown	Neuropsychology review	2022
An update on diagnostic and prognostic biomarkers for traumatic brain injury. [PMID:29338452]	Unknown	Expert review of molecular dia	2019
An update on diagnostic and prognostic biomarkers for traumatic brain injury. [PMID:29338452]	Unknown	Expert review of molecular dia	2019
An updated histological classification system for multiple sclerosis lesions. [PMID:27988845]	Kuhlmann T, Ludwin S, Prat A	Acta Neuropathol	2017
What do your eyes reveal about your foreign language? Reading emotional sentence [PMID:28973016]	["Iacozza, Sara", "Costa, Albert", "Du\u	PloS one	2017
What do your eyes reveal about your foreign language? Reading emotional sentence [PMID:28973016]	["Iacozza, Sara", "Costa, Albert", "Du\u	PloS one	2017

Debates (1)

Multi-agent debates referencing this entity

How does gene expression change across age groups (young/middle/old) in hippocam

closed · Rounds: 4 · Score: 1.00 · 2026-04-24

Related Research

Hypotheses and analyses mentioning MBP in their description or question text

No additional research found

MBP