concept

OLIG2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OLIG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

110Connections

0Hypotheses

0Analyses

50Outgoing

49Incoming

0Experiments

0Debates

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💡 Concept Info

Name	OLIG2
Key Genes/Proteins	AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE, APOPTOSIS
Related Diseases	Als, Alzheimer
Related Pathways	Apoptosis, apoptosis pathway

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

OLIG2 Gene

gene · 682 words

→

Pathway Diagram

graph TD
    OLIG2["OLIG2"]
    OLIG2 -->|"regulates"| Astrocyte["Astrocyte"]
    OLIG2 -->|"inhibits"| Als["Als"]
    OLIG2 -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    OLIG2 -->|"inhibits"| Alzheimer["Alzheimer"]
    OLIG2 -->|"inhibits"| Inflammation["Inflammation"]
    OLIG2 -->|"inhibits"| Ms["Ms"]
    OLIG2 -->|"inhibits"| Notch["Notch"]
    OLIG2 -->|"inhibits"| Tgf__["Tgf-Beta"]
    HES1["HES1"] -->|"inhibits"| OLIG2
    ASTROCYTES["ASTROCYTES"] -->|"inhibits"| OLIG2
    NOTCH["NOTCH"] -->|"inhibits"| OLIG2
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"inhibits"| OLIG2
    TNF__["TNF-Alpha"] -->|"inhibits"| OLIG2
    CXCL2["CXCL2"] -->|"inhibits"| OLIG2
    PI3K["PI3K"] -->|"inhibits"| OLIG2
    MBP["MBP"] -->|"inhibits"| OLIG2

Outgoing (61)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Astrocyte	regulates	cell_type	0.80
stem cells	expressed_in	cell_type	0.80
glioblastoma	regulates	disease	0.70
MOG	causes	gene	0.70
astrocytes	expressed_in	cell_type	0.70
Inflammation	inhibits	disease	0.65
Ms	inhibits	disease	0.65
OLIGODENDROCYTE	associated_with	concept	0.65
Neuroinflammation	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
oligodendrocyte	co_discussed	concept	0.65
myelin	co_discussed	concept	0.65
astrocyte	co_discussed	concept	0.65
neuron	co_discussed	concept	0.65
apoptosis	co_discussed	concept	0.65
OLIGODENDROCYTES	produces	cell_type	0.65
PARP1	co_discussed	gene	0.65
Als	inhibits	disease	0.65
Tgf-Β	inhibits	pathway	0.60
SHH	causes	gene	0.60
SHH	inhibits	gene	0.60
TCF7L2	inhibits	gene	0.60
schizophrenia	inhibits	disease	0.60
TCF7L2	regulates	gene	0.60
glutamate signaling	participates_in	pathway	0.60
SOX10	causes	gene	0.60
TCF4	causes	gene	0.60
Notch	inhibits	pathway	0.60
MOG	targets	gene	0.60
APOPTOSIS	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
TNF	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
Pi3K	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Synaptic Plasticity	inhibits	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
ASTROCYTES	inhibits	gene	0.60
AND	activates	gene	0.60
NEURON	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
MYELIN	inhibits	gene	0.60
CREB	inhibits	gene	0.60
STING	co_expressed_with	gene	0.60
glioblastoma	activates	disease	0.60
PARP1	co_expressed_with	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
glioblastoma	inhibits	disease	0.60
Huntington's disease	inhibits	disease	0.60

Incoming (49)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
Transcranial near-infrared light	upregulates	compound	0.85
GBM	regulates	gene	0.70
OLIGODENDROCYTE	stabilizes	cell_type	0.70
MTOR	co_discussed	gene	0.65
MBP	co_discussed	gene	0.65
APOE	co_discussed	gene	0.65
GFAP	co_discussed	gene	0.65
LRRK2	co_discussed	gene	0.65
SUBVENTRICULAR ZONE	causes	brain_region	0.65
MBP	interacts_with	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
EXERCISE	activates	gene	0.60
OLIGODENDROCYTE	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
CXCL2	inhibits	gene	0.60
ASCL1	interacts_with	gene	0.60
GEM	inhibits	gene	0.60
GBM	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
GBM	activates	gene	0.60
PI3K	inhibits	gene	0.60
MBP	inhibits	gene	0.60
ASCL1	regulates	gene	0.60
ASCL1	activates	gene	0.60
AKT1	co_expressed_with	gene	0.60
AKT1	activates	gene	0.60
NESTIN	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
HES1	inhibits	gene	0.60
AND	associated_with	gene	0.60
NOTCH	inhibits	gene	0.60
OLIGODENDROCYTES	stabilizes	cell_type	0.60
DNA	interacts_with	gene	0.60
MEK	inhibits	gene	0.60
MBP	activates	gene	0.55
MOG	activates	gene	0.55
MOG	interacts_with	gene	0.55
MBP	expressed_in	gene	0.55
MOG	expressed_in	gene	0.55
DNA	activates	gene	0.55
WHITE MATTER	associated_with	brain_region	0.50
PARP1	associated_with	gene	0.45
METFORMIN	associated_with	drug	0.45
CORPUS CALLOSUM	associated_with	brain_region	0.45
SPINAL CORD	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
SUBVENTRICULAR ZONE	associated_with	brain_region	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning OLIG2 in their description or question text

No additional research found