concept

BMP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BMP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

173Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	BMP
Key Genes/Proteins	ACHE, Actin, ACVR1, AD, ADAM10, AIF1
Related Diseases	Als, ALS
Linked Hypotheses	1 hypotheses

Wiki Pages (12)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    BMP["BMP"]
    BMP -->|"involved_in"| Cranial_Suture_Patency["Cranial Suture Patency"]
    BMP -->|"interacts"| MTOR["MTOR"]
    BMP -->|"activates"| Inflammation["Inflammation"]
    BMP -->|"inhibits"| Parkinson["Parkinson"]
    BMP -->|"inhibits"| ALS["ALS"]
    BMP -->|"causes"| Neuroinflammation["Neuroinflammation"]
    BMP -->|"causes"| Als["Als"]
    BMP -->|"causes"| Diabetes["Diabetes"]
    Wnt["Wnt"] -->|"interacts"| BMP
    AMPK["AMPK"] -->|"activates"| BMP
    MTOR -->|"activates"| BMP
    SIRT1["SIRT1"] -->|"activates"| BMP
    NLRP3["NLRP3"] -->|"activates"| BMP
    PI3K["PI3K"] -->|"activates"| BMP
    ACVR1["ACVR1"] -->|"activates"| BMP
    AKT["AKT"] -->|"activates"| BMP

Outgoing (119)

Target	Relation	Type	Str
Cranial Suture Patency	involved_in	phenotype	0.85
vascular remodeling	modulates	process	0.80
Pulmonary Arterial Hypertension	involved_in	disease	0.75
WNT	inhibits	gene	0.70
LDLR	inhibits	gene	0.70
HTT	interacts_with	gene	0.70
LAMP1	interacts_with	gene	0.70
NEURONS	interacts_with	cell_type	0.70
SYT1	activates	gene	0.70
MACROPHAGE	enhances	cell_type	0.70
MACROPHAGE	associated_with	cell_type	0.70
ENDOTHELIAL	activates	cell_type	0.70
MACROPHAGE	inhibits	cell_type	0.70
PINK1	activates	gene	0.70
ULK1	activates	gene	0.70
neurons	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
Glioblastoma	causes	disease	0.65
Inflammation	activates	disease	0.65
MTOR	interacts_with	gene	0.65
Als	causes	disease	0.65
Neuroinflammation	causes	disease	0.65
Diabetes	causes	disease	0.65
Parkinson	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
INFLAMMATION	activates	gene	0.60
SIRT1	activates	gene	0.60
AND	activates	gene	0.60
Insulin Signaling	inhibits	pathway	0.60
Dna Repair	associated_with	pathway	0.60
Epigenetic	associated_with	pathway	0.60
T Cell	associated_with	cell_type	0.60
Insulin	inhibits	protein	0.60
NF-kB signaling	participates_in	pathway	0.60
BRAF	regulates	gene	0.60
EGFR	regulates	gene	0.60
NF-KB	activates	gene	0.60
SOX9	activates	gene	0.60
Inflammasome	activates	pathway	0.60
Nf-Kb	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
Mtor	activates	pathway	0.60
Stem Cell	activates	cell_type	0.60
AKT	activates	gene	0.60
Macrophage	activates	cell_type	0.60
AMPK	activates	gene	0.60
MICROGLIA	regulates	cell_type	0.60
WNT	regulates	gene	0.60

Incoming (54)

Source	Relation	Type	Str
BDNF	regulates	protein	0.90
Wnt	interacts_with	pathway	0.80
MTOR	activates	gene	0.60
SIRT1	activates	gene	0.60
NLRP3	activates	gene	0.60
PI3K	activates	gene	0.60
MACF1	causes	gene	0.60
GLIOBLASTOMA	causes	gene	0.60
NOTCH2	causes	gene	0.60
AMPK	activates	gene	0.60
GBM	causes	gene	0.60
APOE4	activates	gene	0.60
APOE3	associated_with	gene	0.60
APOE4	associated_with	gene	0.60
ACHE	regulates	gene	0.60
AUTOPHAGY	activates	pathway	0.60
BCL2	activates	gene	0.60
PPARG	causes	gene	0.60
ACVR1	activates	gene	0.60
AKT	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NF-ΚB	activates	gene	0.60
SOX9	activates	gene	0.60
AND	activates	gene	0.60
TAK1	activates	gene	0.60
SMAD4	activates	gene	0.60
ATP13A2	regulates	gene	0.60
ATP13A2	associated_with	gene	0.60
BACE1	degrades	gene	0.60
PI3K	inhibits	gene	0.60
MUTYH	associated_with	gene	0.60
DNA	associated_with	gene	0.60
ATP13A2	expresses	gene	0.60
AUTOPHAGY	co_discussed	pathway	0.60
AD	degrades	gene	0.60
ADAM10	degrades	gene	0.60
AIF1	degrades	gene	0.60
APP	degrades	gene	0.60
ATG5	degrades	gene	0.60
AUTOPHAGY	degrades	pathway	0.60
AΒ	degrades	gene	0.60
ASTROCYTES	co_discussed	cell_type	0.60
PARKINSON	inhibits	gene	0.60
LRRK2	inhibits	gene	0.60
AND	inhibits	gene	0.60
APOE	activates	gene	0.60
ASTROCYTE	activates	cell_type	0.60
ASTROCYTES	activates	cell_type	0.60
LYSOSOME	inhibits	gene	0.60
ATG5	co_discussed	gene	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
BMP4 Pathway Inhibition for Oligodendrocyte Myelination Supp	0.620	neurodegeneration	Cell type vulnerability in Alzheimer's D

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (2)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
ANGPTL4 regulates the adipogenic-osteogenic differentiation balance of bone marr [PMID:41482017]	Huang F, Zhu Z, Xing Q, Li M	Biochimie	2026	0
BMP4 dose dictates lineage specification bias in human periodontal ligament stem [PMID:41568233]	Li Y, Tang Q, Li L, Lin C, Guo M et al.	Front Bioeng Biotechnol	2025	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BMP in their description or question text

No additional research found

BMP

Understanding Entity Pages

Wiki Pages (12)

BMPR2 Gene

BMPR1A — Bone Morphogenetic Protein Receptor Type 1A

TGF-β/BMP Signaling Pathway in Neurodegeneration

BMP4 Protein

BMPR1A (ALK3) Protein

BMP2 — Bone Morphogenetic Protein 2

PD TGF-beta/BMP Signaling Companies

BMP4 Gene (Bone Morphogenetic Protein 4)

BMP7 Gene (Bone Morphogenetic Protein 7)

BMPR2 Protein

BMP2 Protein

BMPR1B Gene