gene

XIAP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XIAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

211Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

XIAP is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, therapeutic target. Associated with Als, Alzheimer, Amyotrophic Lateral Sclerosis. Connected to 111 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	XIAP
Full Name	X-Linked Inhibitor of Apoptosis
Chromosome	Xq25
Function	XIAP (X-linked Inhibitor of Apoptosis) is the best-characterized member of the Inhibitor of Apoptosis (IAP) protein family.
Primary Expression	neuronal tissues where it protects against apoptosis induced by various stimuli including oxidative stress, mitochondrial dysfu
Pathways	NF-κB
UniProt ID	[P98170](https://www.uniprot.org/uniprot/P98170)
Ensembl ID	ENSG00000101966
GeneCards	XIAP
Human Protein Atlas	XIAP
Associated Diseases	Cancer, Ms
Interactions	ACHE, AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
KG Connections	211 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

XIAP

gene · 556 words

→

X-linked Inhibitor of Apoptosis Protein (XIAP)

protein · 1322 words

→

Pathway Diagram

graph TD
    XIAP["XIAP"]
    Inflammation{"Inflammation"}
    XIAP -->|"activates"| Inflammation
    Alzheimer{"Alzheimer"}
    XIAP -->|"activates"| Alzheimer
    Traumatic_Brain_Injury{"Traumatic Brain Injury"}
    XIAP -->|"activates"| Traumatic_Brain_Injury
    Stroke{"Stroke"}
    XIAP -->|"activates"| Stroke
    Multiple_Sclerosis{"Multiple Sclerosis"}
    XIAP -->|"activates"| Multiple_Sclerosis
    Als{"Als"}
    XIAP -->|"activates"| Als
    Neuroinflammation{"Neuroinflammation"}
    XIAP -->|"activates"| Neuroinflammation
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    XIAP -->|"activates"| Amyotrophic_Lateral_Sclerosis
    Parkinson{"Parkinson"}
    XIAP -->|"activates"| Parkinson
    Ms{"Ms"}
    XIAP -->|"activates"| Ms
    XIAP -->|"associated with"| Ms
    INFLAMMATION["INFLAMMATION"]
    XIAP -->|"activates"| INFLAMMATION
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"activates"| XIAP
    NF_KB["NF-KB"]
    NF_KB -->|"activates"| XIAP
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| XIAP
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"activates"| XIAP
    BCL2L1["BCL2L1"]
    BCL2L1 -->|"biomarker for"| XIAP
    CASP1["CASP1"]
    CASP1 -->|"associated with"| XIAP
    NFKBIA["NFKBIA"]
    NFKBIA -->|"associated with"| XIAP
    CASP8["CASP8"]
    CASP8 -->|"biomarker for"| XIAP
    IL1B["IL1B"]
    IL1B -->|"associated with"| XIAP
    style XIAP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (100)

Target	Relation	Type	Str
Apoptosis	inhibits	pathway	0.90
ULK1	phosphorylates	protein	0.85
RIPK2	ubiquitinates	gene	0.80
Cancer	therapeutic_target	disease	0.75
CANCER	therapeutic_target	gene	0.70
APOPTOSIS	inhibits	gene	0.70
Apoptosis	activates	pathway	0.70
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Parkinson	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Stroke	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Ms	associated_with	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Traumatic Brain Injury	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Tumor	activates	disease	0.65
Breast Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Diabetes	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Leukemia	inhibits	disease	0.65
Insulin Resistance	inhibits	disease	0.65
Fatty Liver	inhibits	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
BCL-2	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
Microrna	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
Akt	inhibits	pathway	0.60
PARKINSON	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
STROKE	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	activates	gene	0.60
CYTOKINES	activates	gene	0.60
MAPK	activates	gene	0.60
NF-KB	activates	gene	0.60
Ubiquitin	activates	protein	0.60
MAPK signaling	participates_in	pathway	0.60

Incoming (111)

Source	Relation	Type	Str
ATG5	activates	gene	0.70
DBH	activates	gene	0.70
ENDOTHELIAL	inhibits	cell_type	0.70
GASDERMIN	activates	gene	0.70
GPX4	activates	gene	0.70
HIF1A	activates	gene	0.70
NFKB	activates	gene	0.70
SOD1	activates	gene	0.70
TFEB	activates	gene	0.70
VEGF	inhibits	gene	0.70
ULK1	activates	gene	0.70
GSK3B	activates	gene	0.70
LAMP1	activates	gene	0.70
LRRK2	activates	gene	0.70
MACROPHAGE	activates	cell_type	0.70
NLRP3	activates	gene	0.70
OPTN	activates	gene	0.70
PYCARD	activates	gene	0.70
SQSTM1	activates	gene	0.70
STING	activates	gene	0.70
TNF	activates	gene	0.70
ACHE	activates	gene	0.70
AMPK	activates	gene	0.70
BECN1	activates	gene	0.70
CGAS	activates	gene	0.70
FOXP3	activates	gene	0.70
APOPTOSIS	inhibits	gene	0.70
ERK	expressed_in	gene	0.60
MIRNAS	inhibits	gene	0.60
KRAS	therapeutic_target	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
AUTOPHAGY	regulates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
STROKE	activates	gene	0.60
MAPK	activates	gene	0.60
AND	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
PARKINSON	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
BRAIN INJURY	activates	gene	0.60
EGF	activates	gene	0.60
SRC	inhibits	gene	0.60
SRC	expressed_in	gene	0.60
BCL2L1	biomarker_for	gene	0.60
CASP1	associated_with	gene	0.60
NFKBIA	associated_with	gene	0.60
CASP8	biomarker_for	gene	0.60
IL1B	associated_with	gene	0.60
ULK1	regulates	gene	0.60
NOD2	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning XIAP in their description or question text

No additional research found