concept

TNFRSF11A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFRSF11A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

0Analyses

24Outgoing

13Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	TNFRSF11A
Key Genes/Proteins	App, GAIN, GENES, HNRNPA1, HNRNPA2B1, JUN
Related Diseases	Als, ALS, Early-Onset Familial Paget's Disease, Expansile Skeletal Hyperphosphatasia, Familial Expansile Osteolysis

Wiki Pages (1)

Knowledge base pages for this entity

RANK (TNFRSF11A)

gene · 723 words

→

Pathway Diagram

graph TD
    TNFRSF11A["TNFRSF11A"]
    TNFRSF11A -->|"encodes"| RANK["RANK"]
    TNFRSF11A -->|"causes"| Familial_Expansile_Osteolysis["Familial Expansile Osteolysis"]
    TNFRSF11A -->|"causes"| Early_Onset_Familial_Paget_s_D["Early-Onset Familial Paget's Disease"]
    TNFRSF11A -->|"causes"| Expansile_Skeletal_Hyperphosph["Expansile Skeletal Hyperphosphatasia"]
    TNFRSF11A -->|"activates"| Neurodegeneration["Neurodegeneration"]
    TNFRSF11A -->|"activates"| ALS["ALS"]
    TNFRSF11A -->|"activates"| Als["Als"]
    TNFRSF11A -->|"activates"| HNRNPA2B1["HNRNPA2B1"]
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| TNFRSF11A
    GENES["GENES"] -->|"activates"| TNFRSF11A
    SQSTM1["SQSTM1"] -->|"activates"| TNFRSF11A
    TIA1["TIA1"] -->|"activates"| TNFRSF11A
    HNRNPA1["HNRNPA1"] -->|"activates"| TNFRSF11A
    RANKL["RANKL"] -->|"activates"| TNFRSF11A
    TNFRSF11B["TNFRSF11B"] -->|"activates"| TNFRSF11A
    MATR3["MATR3"] -->|"activates"| TNFRSF11A

Outgoing (24)

Target	Relation	Type	Str
RANK	associated_with	protein	1.00
RANK	encodes	protein	0.95
Familial Expansile Osteolysis	causes	disease	0.95
Early-Onset Familial Paget's Disease	causes	disease	0.95
Expansile Skeletal Hyperphosphatasia	causes	disease	0.95
Paget'S Disease Of Bone	causes	disease	0.95
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
TNFRSF11B	activates	gene	0.60
HNRNPA1	activates	gene	0.60
VCP	activates	gene	0.60
RANKL	activates	gene	0.60
RANK	activates	gene	0.60
TIA1	activates	gene	0.60
GENES	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
SQSTM1	activates	gene	0.60
MATR3	activates	gene	0.60
HNRNPA2B1	activates	gene	0.60
GAIN	activates	gene	0.60
JUN	activates	gene	0.60
Osteoclast	activates	cell_type	0.60
App	activates	protein	0.60

Incoming (13)

Source	Relation	Type	Str
RANKL	activates	gene	0.60
HNRNPA1	activates	gene	0.60
RANK	activates	gene	0.60
JUN	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GENES	activates	gene	0.60
SQSTM1	activates	gene	0.60
TIA1	activates	gene	0.60
TNFRSF11B	activates	gene	0.60
MATR3	activates	gene	0.60
VCP	activates	gene	0.60
GAIN	activates	gene	0.60
HNRNPA2B1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TNFRSF11A in their description or question text

No additional research found