protein 2,974 words KG: HNRNPA1
Contents

HNRNPA1 Protein

🔬 Protein Info
Gene SymbolHNRNPA1
AliasesPage for HNRNPA1
Chromosome12q13.13
FunctionIn neurons and other cell types, hnRNP A1 plays critical roles in multiple aspects of RNA metabolism and cellular stress response:
Primary ExpressionUbiquitous, high in brain and muscle
Subcellular Localization</strong></td><td>Nucleus, cytoplasm, stress granules</td></tr>
Molecular Weight38 kDa
Amino Acids372 aa
PathwaysAlpha-Synuclein, Er Stress, Synaptic Plasticity
UniProt IDP09651
NCBI Gene ID3178
Ensembl IDENSG00000166086
OMIM164017
GeneCardsHNRNPA1
Human Protein AtlasHNRNPA1
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Anxiety, Cancer, Carcinoma, dementia
Known Drugs/CompoundsPACLITAXEL
InteractionsAGING, ALOX15, AMYOTROPHIC LATERAL SCLEROSIS, AND, App, APP
KG Connections424 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (19)

Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
PARP1 Inhibition Therapy
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71

Related Analyses (8)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (6)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: stabilizes
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: activates
Alzheimer Indonesia
institution · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

HNRNPA1 associated_with VALOSIN
USP7 inhibits HNRNPA1
HNRNPA1 inhibits ALOX15
JUN activates HNRNPA1
RANK activates HNRNPA1
RANKL activates HNRNPA1
GAIN activates HNRNPA1
PTBP1 expressed_in HNRNPA1
TARDBP expressed_in HNRNPA1
CALCOCO2 activates HNRNPA1

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