protein

METTL3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about METTL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

385Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

METTL3 is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with ALS, Aging, Als. Connected to 197 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	METTL3
Aliases	m6A Methyltransferase
Function	METTL3 (Methyltransferase Like 3) is the catalytic core component of the N6-methyladenosine (m6A) methyltransferase complex.
Subcellular Localization	</strong> Nucleus, cytosol</div> <div class="infobox-row"><strong>Protein Fami
Molecular Weight	64.6 kDa
Pathways	Autophagy, Akt, Pi3K, Wnt, Complement
GeneCards	METTL3
Human Protein Atlas	METTL3
Associated Diseases	Aging, Als, Alzheimer's disease, Cancer, Ftd
Known Drugs/Compounds	levodopa, metformin
Interactions	ACSL5, AKT, AMBRA1, AND, APOPTOSIS, AUTOPHAGY
KG Connections	384 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

METTL3 Protein (m6A Methyltransferase)

protein · 798 words

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Pathway Diagram

graph TD
    METTL3["METTL3"]
    METTL3 -->|"regulates"| proteostasis["proteostasis"]
    METTL3 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    METTL3 -->|"target for"| Als["Als"]
    METTL3 -->|"target for"| Aging["Aging"]
    METTL3 -->|"target for"| Ms["Ms"]
    METTL3 -->|"target for"| Cancer["Cancer"]
    METTL3 -->|"inhibits"| Carcinoma["Carcinoma"]
    ELAVL2["ELAVL2"] -->|"target for"| METTL3
    CLPP["CLPP"] -->|"target for"| METTL3
    PI3K["PI3K"] -->|"target for"| METTL3
    MTOR["MTOR"] -->|"target for"| METTL3
    BDNF["BDNF"] -->|"target for"| METTL3
    HNRNPA2B1["HNRNPA2B1"] -->|"target for"| METTL3
    GENES["GENES"] -->|"target for"| METTL3
    IGF2BP1["IGF2BP1"] -->|"target for"| METTL3
    ACSL5["ACSL5"] -->|"inhibits"| METTL3
    BAMBI["BAMBI"] -->|"inhibits"| METTL3

Outgoing (243)

Target	Relation	Type	Str
Cancer	activates	disease	0.95
N6-Methyladenosine	regulates	compound	0.95
Parkinson'S Disease	risk_factor_for	disease	0.95
m6A methylation	regulates	process	0.95
m6A modification	mediates	process	0.95
Parkinson's Disease	risk_factor_for	disease	0.90
dopaminergic neurons	expressed_in	cell_type	0.90
FZD10	regulates	gene	0.90
Substantia Nigra	expressed_in	brain_region	0.90
Viral Gene Expression	regulates	process	0.85
Alternative Splicing	regulates	process	0.85
m6A epitranscriptomic modification	mediates	process	0.85
PPARGC1A	downregulates	gene	0.85
AUTOPHAGY	associated_with	process	0.80
Alzheimer's disease	implicated_in	disease	0.80
NEUROINFLAMMATION	modulates	process	0.80
Translation Fidelity	regulates	process	0.80
ALZHEIMER'S DISEASE	modulates	disease	0.80
CANCER	activates	gene	0.80
Autophagy	activates	pathway	0.80
Translation Fidelity	modulates	process	0.75
Als	inhibits	disease	0.75
Tumor	associated_with	disease	0.75
RNA	regulates	gene	0.70
Apoptosis	inhibits	pathway	0.70
proteostasis	regulates	process	0.70
Neurodegeneration	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Breast Cancer	activates	disease	0.65
Lung Cancer	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Ftd	therapeutic_target	disease	0.65
Inflammation	causes	disease	0.65
Aging	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Lymphoma	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Traumatic Brain Injury	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Stroke	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Aging	encodes	disease	0.65
Neurodegeneration	encodes	disease	0.65
Als	encodes	disease	0.65
Carcinoma	activates	disease	0.65
Carcinoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Aging	associated_with	disease	0.65

Incoming (142)

Source	Relation	Type	Str
HPV E6	degrades	protein	0.95
E6	degrades	protein	0.95
E6AP	mediates	protein	0.90
β-catenin	upstream_of	protein	0.85
AUTOPHAGY	activates	gene	0.70
AUTOPHAGY	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
LONP1	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
RAB5	therapeutic_target	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
IGF2BP2	activates	gene	0.60
PRKN	activates	gene	0.60
C1Q	therapeutic_target	gene	0.60
APOPTOSIS	inhibits	gene	0.60
C1Q	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
CLPP	associated_with	gene	0.60
GENES	contributes_to	gene	0.60
PI3K	activates	gene	0.60
AND	inhibits	gene	0.60
AMBRA1	inhibits	gene	0.60
IGF2BP1	encodes	gene	0.60
MAPK	encodes	gene	0.60
RAB11	encodes	gene	0.60
YTHDF1	encodes	gene	0.60
AUTOPHAGY	encodes	gene	0.60
metformin	targets	drug	0.60
IGF2BP1	associated_with	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
AKT	associated_with	gene	0.60
ACSL5	activates	gene	0.60
BAMBI	activates	gene	0.60
WNT	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
HNRNPA1	activates	gene	0.60
EXOSOMES	activates	gene	0.60
STAT3	activates	gene	0.60
RNA	activates	gene	0.60
SLC16A1-AS1	activates	gene	0.60
SLC16A1	activates	gene	0.60
RAB5	encodes	gene	0.60
CLPP	encodes	gene	0.60
BDNF	encodes	gene	0.60
ALS	encodes	gene	0.60
ELAVL2	encodes	gene	0.60
STX17	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
METTL3-Mediated m6A Modification of lncRNA-0021 Regulates mi	0.754	molecular neurobiology	View

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning METTL3 in their description or question text

No additional research found