gene 1,032 words KG: HNRNPA1
Contents

HNRNPA1 - Heterogeneous Nuclear Ribonucleoprotein A1

🧬 Gene Info
Gene SymbolHNRNPA1
Full NameHeterogeneous Nuclear Ribonucleoprotein A1
AliasesPage for HNRNPA1
Chromosome12q13.13
FunctionIn neurons and other cell types, hnRNP A1 plays critical roles in multiple aspects of RNA metabolism and cellular stress response:
Primary ExpressionUbiquitous, high in brain and muscle
Molecular Weight38 kDa
Amino Acids372 aa
PathwaysAlpha-Synuclein, Er Stress, Synaptic Plasticity
UniProt IDP09651
NCBI Gene ID3178
Ensembl IDENSG00000166086
OMIM164017
GeneCardsHNRNPA1
Human Protein AtlasHNRNPA1
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Anxiety, Cancer, Carcinoma, dementia
Known Drugs/CompoundsPACLITAXEL
InteractionsAGING, ALOX15, AMYOTROPHIC LATERAL SCLEROSIS, AND, App, APP
KG Connections424 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (19)

Axonal RNA Transport Reconstitution
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
VCP-Mediated Autophagy Enhancement
Score: 0.57
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85
PARP1 Inhibition Therapy
Score: 0.74

Related Analyses (7)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40

See Also (6)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: stabilizes
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: activates
Alzheimer Indonesia
institution · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

HNRNPA1 associated_with VALOSIN
USP7 inhibits HNRNPA1
HNRNPA1 inhibits ALOX15
JUN activates HNRNPA1
RANK activates HNRNPA1
RANKL activates HNRNPA1
GAIN activates HNRNPA1
PTBP1 expressed_in HNRNPA1
TARDBP expressed_in HNRNPA1
CALCOCO2 activates HNRNPA1

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