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protein 951 words KG: HIF1A
Contents

HIF-1α Protein

🔬 Protein Info
Gene SymbolHIF
Full Name1α Protein
GeneCardsHIF
Human Protein AtlasHIF
Associated DiseasesAD, ALI, Als, Alzheimer, AMI
Known Drugs/Compoundsquercetin, rapamycin
InteractionsABCD3, AGING, AKK, AKT, AKT1, ALS
KG Connections1341 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (29)

Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67Blood-Brain Barrier SPM Shuttle System
Score: 0.53Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65APOE-Dependent Autophagy Restoration
Score: 0.88Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76Transcriptional Autophagy-Lysosome Coupling
Score: 0.76Senescence-Activated NAD+ Depletion Rescue
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74Phase-Separated Organelle Targeting
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72Stress Granule Phase Separation Modulators
Score: 0.72
pg 1/2Next →

Related Analyses (15)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · completedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archived

See Also (15)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussedABCD3 Gene
gene · KG edge: activatesAlzheimer Indonesia
institution · KG edge: activatesAging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibitsPackard Center for ALS Research
institution · KG edge: activates

Knowledge Graph (12 edges)

sorafenib regulates HIF1A
HIF1A regulates SLC7A11
FOXO3 regulates HIF1A
STAT1 activates HIF1A
STAT3 activates HIF1A
CAT interacts_with HIF1A
OPTN interacts_with HIF1A
DNM1L interacts_with HIF1A
CANX interacts_with HIF1A
LGALS3 interacts_with HIF1A

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