concept

WNT SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

535Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	WNT SIGNALING
Key Genes/Proteins	AHR, AKT, ALZHEIMER, AMPK, AMYLOID, AMYLOID-BETA
Related Diseases	AGING, ALS, Alzheimer'S Disease, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS

Pathway Diagram

graph TD
    WNT_SIGNALING["WNT SIGNALING"]
    WNT_SIGNALING -->|"dysregulated_in"| Alzheimer_s_disease["Alzheimer's disease"]
    WNT_SIGNALING -->|"activates"| MYC["MYC"]
    WIF1["WIF1"] -->|"inhibits"| WNT_SIGNALING
    MYC -->|"regulates"| WNT_SIGNALING
    SYNAPSE["SYNAPSE"] -->|"regulates"| WNT_SIGNALING
    SNCA["SNCA"] -->|"regulates"| WNT_SIGNALING
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| WNT_SIGNALING
    SQSTM1["SQSTM1"] -->|"activates"| WNT_SIGNALING
    BECN1["BECN1"] -->|"activates"| WNT_SIGNALING

Outgoing (86)

Target	Relation	Type	Str
Alzheimer's disease	dysregulated_in	disease	0.90
HIF1A	activates	gene	0.90
Astrocyte-Synapse Contact	inhibits	process	0.88
MYC	activates	gene	0.80
Prostate Cancer	associated_with	disease	0.80
astrocytes	active_in	cell_type	0.70
neurons	active_in	cell_type	0.70
tau phosphorylation	mediates	process	0.70
NEURAL STEM CELLS	activates	cell_type	0.70
DNMT3A	regulates	gene	0.70
PSD95	inhibits	gene	0.70
NEURONS	activates	cell_type	0.65
NEURODEGENERATION	treats	disease	0.65
OLIGODENDROCYTES	regulates	cell_type	0.65
NEURONS	inhibits	cell_type	0.65
VEGFA	associated_with	gene	0.65
AUTOPHAGY	regulates	phenotype	0.65
WNT3A	activates	gene	0.65
APP	inhibits	gene	0.65
APOPTOSIS	activates	phenotype	0.65
NEURONS	regulates	cell_type	0.65
MITOCHONDRIAL DYSFUNCTION	interacts_with	phenotype	0.65
NEURODEGENERATION	exacerbates	disease	0.65
NEURODEGENERATION	activates	disease	0.65
NEUROGENESIS	causes	phenotype	0.65
MITOCHONDRIAL DYSFUNCTION	degrades	phenotype	0.65
STEM CELLS	associated_with	cell_type	0.60
synaptic plasticity	crosstalk_with	pathway	0.60
microglia	active_in	cell_type	0.60
neural stem cells	active_in	cell_type	0.60
amyloid aggregation	mediates	process	0.60
unfolded protein response	crosstalk_with	pathway	0.60
temporal lobe	active_in	brain_region	0.60
oligodendrocytes	active_in	cell_type	0.60
NEUROGENESIS	participates_in	phenotype	0.55
NEURODEGENERATION	implicated_in	disease	0.55
WNT1	expressed_in	gene	0.55
ALZHEIMER'S DISEASE	implicated_in	disease	0.55
NEUROGENESIS	implicated_in	phenotype	0.55
BDNF	associated_with	gene	0.50
LITHIUM	associated_with	drug	0.50
APP	associated_with	gene	0.50
DENTATE GYRUS	associated_with	brain_region	0.50
PSD95	associated_with	gene	0.50
NEURONS	associated_with	cell_type	0.50
GSK3B	associated_with	gene	0.50
DNMT3A	associated_with	gene	0.50
TEMPORAL LOBE	associated_with	concept	0.50
AUTOPHAGY	associated_with	phenotype	0.50
PD-L1	inhibits	concept	0.50

Incoming (449)

Source	Relation	Type	Str
PI3K-AKT-mTOR Pathway	interacts_with	pathway	0.90
GSK3	participates_in	gene	0.90
GSK3B	participates_in	gene	0.90
WIF1	inhibits	protein	0.90
WIF1	regulates	gene	0.85
MYC	regulates	gene	0.85
MAPT	participates_in	gene	0.80
BACE1	participates_in	gene	0.80
TREM2	participates_in	gene	0.80
APP	participates_in	gene	0.80
MAPK1	participates_in	gene	0.80
ERK	participates_in	gene	0.80
PI3K	participates_in	gene	0.80
BDNF	interacts_with	gene	0.80
WNT	participates_in	gene	0.80
CLU	modulates	protein	0.75
SNCA	regulates	gene	0.75
BECN1	participates_in	gene	0.70
GAPDH	participates_in	gene	0.70
glioblastoma	involves	disease	0.70
LC3	participates_in	gene	0.70
SIRT1	participates_in	gene	0.70
MYC	participates_in	gene	0.70
SQSTM1	participates_in	gene	0.70
MAP1LC3	participates_in	gene	0.70
MET	participates_in	gene	0.70
RNA	participates_in	gene	0.70
AMPK	participates_in	gene	0.70
PKM2	participates_in	gene	0.70
CDK5	participates_in	gene	0.70
ATG	participates_in	gene	0.70
MTOR	participates_in	gene	0.70
LRP1	participates_in	gene	0.70
MMP2	participates_in	gene	0.70
PSEN1	participates_in	gene	0.70
AKT	participates_in	gene	0.70
BDNF	activates	gene	0.70
Alzheimer's disease	involves	disease	0.70
TGF	participates_in	gene	0.70
WIF1	participates_in	gene	0.70
TH	inhibits	gene	0.65
TH	targets	gene	0.65
TDP-43	regulates	gene	0.65
REMYELINATION	regulates	phenotype	0.65
MICROGLIA	activates	cell_type	0.65
LACTATE	inhibits	phenotype	0.65
NBR1	participates_in	gene	0.60
NDP52	participates_in	gene	0.60
ULK1	participates_in	gene	0.60
CREB	participates_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Inhibitory Neuron-Selective WNT Signaling Restoration	0.554	neurodegeneration	Which cell types show the most significa

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WNT SIGNALING in their description or question text

No additional research found