gene

DBH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DBH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

61Connections

0Hypotheses

0Analyses

42Outgoing

19Incoming

0Experiments

0Debates

Summary

Enzyme converting dopamine to norepinephrine

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🧬 Gene Info

Gene Symbol	DBH
Chromosome	9q34.2
Protein Type	Gene
Function	DBH catalyzes the oxidative hydroxylation of dopamine to produce norepinephrine.
Subcellular Localization	the Golgi apparatus and secretory vesicles of noradrenergic and adrenergic neurons. DBH deficiency
Molecular Weight	73 kDa
Amino Acids	603 aa
GeneCards	DBH
Human Protein Atlas	DBH
Gene	DBH (chromosome 9q34.2)
Protein Class	Copper-containing monooxygenase
Protein Size	603 amino acids
Primary Localization	Golgi apparatus, secretory vesicles of noradrenergic neurons
Cofactor Requirement	Ascorbate (vitamin C), copper
Disease Associations	DBH deficiency, orthostatic hypotension, ADHD, schizophrenia, PD
Associated Diseases	ALS
Interactions	ADRA1A, ADRA2A, ADRB1, AMPK, APP, ATG5
KG Connections	61 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DBH["DBH"] -->|"associated_with"| ALS["ALS"]
    DBH["DBH"] -->|"co_expressed_with"| ERBB4["ERBB4"]
    DBH["DBH"] -->|"co_expressed_with"| IL1RL1["IL1RL1"]
    ADRA1A["ADRA1A"] -->|"co_expressed_with"| DBH["DBH"]
    ADRA2A["ADRA2A"] -->|"co_expressed_with"| DBH["DBH"]
    DBH["DBH"] -->|"implicated_in"| neurodegeneration["neurodegeneration"]
    style DBH fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (42)

Target	Relation	Type	Str
NLRP3	activates	gene	0.70
ENDOTHELIAL	activates	cell_type	0.70
GASDERMIN	activates	gene	0.70
GPX4	activates	gene	0.70
HIF1A	activates	gene	0.70
NFKB	activates	gene	0.70
SOD1	activates	gene	0.70
SQSTM1	activates	gene	0.70
TFEB	activates	gene	0.70
ULK1	activates	gene	0.70
VEGF	activates	gene	0.70
XIAP	activates	gene	0.70
NEURONS	causes	cell_type	0.70
DRD1	transports	gene	0.70
TAU	activates	gene	0.60
NEURONS	regulates	cell_type	0.60
STING	causes	gene	0.60
NRG1	interacts_with	gene	0.60
ERBB4	interacts_with	gene	0.60
IL33	interacts_with	gene	0.60
ALS	associated_with	disease	0.60
NEURON	regulates	cell_type	0.60
IL1RL1	interacts_with	gene	0.60
OXIDATIVE STRESS	co_discussed	pathway	0.60
TH	co_discussed	gene	0.60
TH	transports	gene	0.60
NEURON	causes	cell_type	0.60
PARKINSON'S DISEASE	co_discussed	disease	0.60
PD	co_discussed	gene	0.60
TH	causes	gene	0.60
HMGB1	activates	gene	0.60
MAPK	activates	gene	0.60
MTOR	activates	gene	0.60
PD	activates	gene	0.60
TP53	activates	gene	0.60
TNF	co_discussed	gene	0.45
KEAP1	co_discussed	gene	0.45
STING	co_discussed	gene	0.45
FGF	co_discussed	gene	0.45
MAO	co_discussed	gene	0.45
SLC6A4	co_discussed	gene	0.45
DRD1	co_discussed	gene	0.40

Incoming (19)

Source	Relation	Type	Str
COMT	transports	gene	0.70
AMPK	activates	gene	0.70
ATG5	activates	gene	0.70
BECN1	activates	gene	0.70
AD	regulates	gene	0.60
AD	co_discussed	gene	0.60
APP	activates	gene	0.60
APOPTOSIS	activates	pathway	0.60
AUTOPHAGY	activates	pathway	0.60
BAX	activates	gene	0.60
BCL2	activates	gene	0.60
ADRA2A	interacts_with	gene	0.60
ADRA1A	interacts_with	gene	0.60
ADRB1	interacts_with	gene	0.60
APP	expresses	gene	0.60
APP	enhances	gene	0.60
BDNF	co_discussed	gene	0.45
CAT	co_discussed	gene	0.45
COMT	co_discussed	gene	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DBH in their description or question text

No additional research found

DBH