gene

DJ1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DJ1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

113Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

0Experiments

0Debates

Summary

DJ1 is a gene implicated in neurodegeneration research. Key relationships include: contributes to, associated with, causes. Associated with Inflammation, Ms, Neuroinflammation. Connected to 34 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PARK7
Full Name	Parkinsonism-Associated Deglycase
Aliases	Protein DJ-1
Chromosome	1p36.23
Protein Family	DJ-1 family, ThiJ/PfpI superfamily
Function	is a multifunctional protein involved in oxidative stress response, mitochondrial function, transcriptional regulation, and protein quality control.
Molecular Weight	20 kDa
Amino Acids	189 aa
Exons	8
Pathways	Neuronal Survival
UniProt ID	Q99497
Ensembl ID	ENSG00000116288
GeneCards	PARK7
Human Protein Atlas	PARK7
Associated Diseases	Inflammation, Neuroinflammation, Parkinson, Parkinson's disease
Known Drugs/Compounds	levodopa
Interactions	AND, ATP13A2, DNAJC6, FBXO7, GBA1, HIF1A
KG Connections	113 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DJ1 — AlphaFold Q99497 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DJ1 — Park7 (Parkinsonism-Associated Deglycase)

gene · 2495 words

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DJ1 (PARK7)

redirect · 667 words

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Pathway Diagram

graph TD
    DJ1["DJ1"]
    Parkinson_s_Disease{"Parkinson's Disease"}
    DJ1 -->|"risk factor for"| Parkinson_s_Disease
    Parkinson_s_disease{"Parkinson's disease"}
    DJ1 -->|"associated with"| Parkinson_s_disease
    mitochondrial_dysfunction(["mitochondrial dysfunction"])
    DJ1 -->|"associated with"| mitochondrial_dysfunction
    Inflammation{"Inflammation"}
    DJ1 -->|"contributes to"| Inflammation
    Parkinson{"Parkinson"}
    DJ1 -->|"contributes to"| Parkinson
    Neuroinflammation{"Neuroinflammation"}
    DJ1 -->|"contributes to"| Neuroinflammation
    Ms{"Ms"}
    DJ1 -->|"contributes to"| Ms
    DJ1 -->|"protects against"| Inflammation
    DJ1 -->|"regulates"| Parkinson
    DJ1 -->|"protects against"| Ms
    DJ1 -->|"protects against"| Neuroinflammation
    GENES["GENES"]
    DJ1 -->|"associated with"| GENES
    VPS35["VPS35"]
    VPS35 -->|"associated with"| DJ1
    LRRK2["LRRK2"]
    LRRK2 -->|"associated with"| DJ1
    GENES -->|"associated with"| DJ1
    PINK1["PINK1"]
    PINK1 -->|"associated with"| DJ1
    PARKIN["PARKIN"]
    PARKIN -->|"associated with"| DJ1
    STING["STING"]
    STING -->|"activates"| DJ1
    NRF2["NRF2"]
    NRF2 -->|"activates"| DJ1
    NEURON["NEURON"]
    NEURON -->|"contributes to"| DJ1
    style DJ1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (90)

Target	Relation	Type	Str
Parkinson's Disease	risk_factor_for	disease	0.95
Proteostasis	regulates	process	0.90
PARKINSON'S DISEASE	associated_with	disease	0.80
Neuronal Survival	involved_in	process	0.75
SNCA	causes	gene	0.70
Parkinson's disease	associated_with	disease	0.70
mitochondrial dysfunction	associated_with	process	0.70
Parkinson's Disease	implicated_in	disease	0.70
Dystonia	expressed_in	disease	0.65
Parkinson	biomarker_for	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Huntington	regulates	disease	0.65
Neuroinflammation	causes	disease	0.65
Inflammation	causes	disease	0.65
Parkinson	causes	disease	0.65
ALS	expressed_in	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	contributes_to	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Ms	contributes_to	disease	0.65
Inflammation	protects_against	disease	0.65
Parkinson	regulates	disease	0.65
Ms	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
oxidative stress response	participates_in	pathway	0.60
Parkinson's disease	causes	disease	0.60
PD	causes	gene	0.60
PD	co_discussed	gene	0.60
DLB	co_discussed	gene	0.60
PINK1	associated_with	gene	0.60
PARKINSON	contributes_to	gene	0.60
AND	causes	gene	0.60
AND	activates	gene	0.60
mitochondrial function	participates_in	pathway	0.60
LRRK2	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
PARKIN	causes	gene	0.60
LRRK2	causes	gene	0.60
STING	activates	gene	0.60
NRF2	activates	gene	0.60
Amyloid	regulates	pathway	0.60
GENES	causes	gene	0.60
GENES	associated_with	gene	0.60
NEURON	contributes_to	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
Oxidative Stress	associated_with	pathway	0.60
stem cells	expressed_in	cell_type	0.60

Incoming (23)

Source	Relation	Type	Str
HIF1A	interacts_with	gene	0.80
Pbt434	upregulates	compound	0.75
PGC1ALPHA	regulates	gene	0.60
PINK1	biomarker_for	gene	0.60
levodopa	targets	drug	0.60
NEURON	contributes_to	gene	0.60
PINK1	causes	gene	0.60
LRRK2	causes	gene	0.60
VPS35	causes	gene	0.60
PARKIN	causes	gene	0.60
ATP13A2	interacts_with	gene	0.60
ATP13A2	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
STING	activates	gene	0.60
NRF2	activates	gene	0.60
PARKINSON'S DISEASE	contributes_to	gene	0.60
PARKINSON	contributes_to	gene	0.60
PARKINSON	regulates	gene	0.60
ATP13A2	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DJ1 in their description or question text

No additional research found