gene

CYCLIN D1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYCLIN D1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

235Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	CYCLIN D1
Pathways	Autophagy, Wnt, Mtor, Metastasis, Cell Cycle
Associated Diseases	Cancer, Carcinoma
Interactions	AKT, AMBRA1, AMPK, AND, APOPTOSIS, ATM
KG Connections	230 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    CYCLIN_D1["CYCLIN D1"] -->|"activates"| Tumor["Tumor"]
    CYCLIN_D1["CYCLIN D1"] -->|"activates"| Cancer["Cancer"]
    CYCLIN_D1["CYCLIN D1"] -->|"expressed in"| Cancer_1["Cancer"]
    CYCLIN_D1["CYCLIN D1"] -->|"activates"| CANCER["CANCER"]
    CYCLIN_D1["CYCLIN D1"] -->|"expressed in"| GENES["GENES"]
    CYCLIN_D1["CYCLIN D1"] -->|"activates"| ALS["ALS"]
    STAT3["STAT3"] -->|"activates"| CYCLIN_D1["CYCLIN D1"]
    MTOR["MTOR"] -->|"associated"| CYCLIN_D1["CYCLIN D1"]
    P62["P62"] -->|"activates"| CYCLIN_D1["CYCLIN D1"]
    MYC["MYC"] -->|"associated"| CYCLIN_D1["CYCLIN D1"]
    style CYCLIN_D1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (128)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CYCLIN D1	data_in	dataset_row	0.00
Cancer	expressed_in	disease	0.75
Tumor	activates	disease	0.75
Cancer	activates	disease	0.75
CANCER	activates	gene	0.70
GENES	expressed_in	gene	0.70
Carcinoma	expressed_in	disease	0.65
Hepatocellular Carcinoma	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Ataxia	activates	disease	0.65
Als	inhibits	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
Glioblastoma	activates	disease	0.65
Lung Cancer	activates	disease	0.65
Als	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Breast Cancer	contributes_to	disease	0.65
Autoimmune	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
ALS	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Pancreatic Cancer	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Glioblastoma	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
P53	inhibits	gene	0.60
CANCER	regulates	gene	0.60
Metastasis	regulates	pathway	0.60
Cell Cycle	regulates	pathway	0.60
Invasion	regulates	pathway	0.60
GLIOBLASTOMA	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
P53	contributes_to	gene	0.60
MDM2	contributes_to	gene	0.60
GENES	contributes_to	gene	0.60
P16	contributes_to	gene	0.60
RB1	contributes_to	gene	0.60
P21	contributes_to	gene	0.60
MMP9	activates	gene	0.60
DNA	inhibits	gene	0.60
HDAC	inhibits	gene	0.60
AKT	inhibits	gene	0.60
Epigenetic	inhibits	pathway	0.60

Incoming (107)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CYCLIN D1	data_in	dataset_row	0.00
STAT3	activates	gene	0.70
RB1	regulates	gene	0.70
P62	activates	gene	0.60
MYC	associated_with	gene	0.60
LC3	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
ATG	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
CSNK1A1	associated_with	gene	0.60
APC	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
CTNNB1	associated_with	gene	0.60
GFP	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
AXIN2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
TCF4	associated_with	gene	0.60
31745295	inhibited	paper	0.60
31745295	inhibit	paper	0.60
BAX	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ROS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
MYC	regulates	gene	0.60
C-MYC	regulates	gene	0.60
WNT	regulates	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
TRIM21	regulates	gene	0.60
CANCER	expressed_in	gene	0.60
AXIN2	regulates	gene	0.60
CD19	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
MTOR	associated_with	gene	0.60
MYC	activates	gene	0.60
KMT2D	therapeutic_target	gene	0.60
NSD2	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
DDB1	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
PI3K	activates	gene	0.60
CDK4	activates	gene	0.60
ATM	activates	gene	0.60
P21	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CYCLIN D1 in their description or question text

No additional research found