gene

CXCL12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCL12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

182Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CXCL12 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in, activates. Associated with Als, Cancer, Carcinoma. Connected to 59 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CXCL12
Protein Type	Gene
Function	CXCL12 is a highly conserved chemokine expressed throughout the central nervous system.
Primary Expression	the brain: - Neurons: High expression in cortex, hippocampus, cerebell
Pathways	Apoptosis, Autophagy, Cell Cycle, Chaperone, Epigenetic
UniProt ID	P48061
GeneCards	CXCL12
Human Protein Atlas	CXCL12
Neurodevelopment	Guiding neuronal migration and axon pathfinding
Neurogenesis	Promoting neural stem cell proliferation and differentiation
Synaptic transmission	Modulating GABAergic and glutamatergic signaling
Neuroprotection	Activating anti-apoptotic pathways
Immune regulation	Controlling leukocyte trafficking
Associated Diseases	Als, Alzheimer, Cancer, Carcinoma, Depression
Interactions	adcy2, ADCY2, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AND
KG Connections	181 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CXCL12 — AlphaFold P48061 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CXCL12["CXCL12"]
    Als{"Als"}
    CXCL12 -->|"associated with"| Als
    Ms{"Ms"}
    CXCL12 -->|"associated with"| Ms
    Depression{"Depression"}
    CXCL12 -->|"associated with"| Depression
    Inflammation{"Inflammation"}
    CXCL12 -->|"associated with"| Inflammation
    Diabetes{"Diabetes"}
    CXCL12 -->|"inhibits"| Diabetes
    Tumor{"Tumor"}
    CXCL12 -->|"activates"| Tumor
    Cancer{"Cancer"}
    CXCL12 -->|"expressed in"| Cancer
    EGFR["EGFR"]
    CXCL12 -->|"activates"| EGFR
    Apoptosis(["Apoptosis"])
    CXCL12 -->|"activates"| Apoptosis
    SRC["SRC"]
    CXCL12 -->|"expressed in"| SRC
    CD38["CD38"]
    CXCL12 -->|"expressed in"| CD38
    CANCER["CANCER"]
    CXCL12 -->|"expressed in"| CANCER
    DDX5["DDX5"]
    DDX5 -->|"regulates"| CXCL12
    SGK1["SGK1"]
    SGK1 -->|"associated with"| CXCL12
    FKBP5["FKBP5"]
    FKBP5 -->|"associated with"| CXCL12
    A2M["A2M"]
    A2M -->|"associated with"| CXCL12
    AQP4["AQP4"]
    AQP4 -->|"associated with"| CXCL12
    TNF["TNF"]
    TNF -->|"associated with"| CXCL12
    P2RX7["P2RX7"]
    P2RX7 -->|"associated with"| CXCL12
    ISG15["ISG15"]
    ISG15 -->|"associated with"| CXCL12
    STAT1["STAT1"]
    STAT1 -->|"associated with"| CXCL12
    USP18["USP18"]
    USP18 -->|"associated with"| CXCL12
    DIABETES_MELLITUS["DIABETES MELLITUS"]
    DIABETES_MELLITUS -->|"inhibits"| CXCL12
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"associated with"| CXCL12
    style CXCL12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (111)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CXCL12	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
CXCR4	binds	protein	0.95
Blood-Brain Barrier	regulates	brain_region	0.90
Cancer	associated_with	disease	0.75
Carcinoma	activates	disease	0.65
Tumor	associated_with	disease	0.65
Prostate Cancer	implicated_in	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
Depression	associated_with	disease	0.65
PYROPTOSIS	activates	phenotype	0.65
Inflammation	associated_with	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
PYROPTOSIS	regulates	phenotype	0.65
Parkinson	biomarker_for	disease	0.65
PYROPTOSIS	biomarker_for	phenotype	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
Aging	activates	disease	0.65
Melanoma	inhibits	disease	0.65
Senescence	activates	disease	0.65
Diabetes	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
Melanoma	associated_with	disease	0.65
TLR4	activates	gene	0.60
CANCER	expressed_in	gene	0.60
Tumor Microenvironment	associated_with	pathway	0.60
Stem Cell	activates	pathway	0.60
Immunotherapy	associated_with	pathway	0.60
CCL2	inhibits	gene	0.60
AUTOPHAGY	activates	gene	0.60
Exocytosis	activates	pathway	0.60
Chaperone	activates	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
Autophagy	activates	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
pyroptosis	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.60
blood-brain barrier	participates_in	pathway	0.60
CXCR4	interacts_with	gene	0.60
GSDMD	activates	gene	0.60
NLRP3	activates	gene	0.60
FOXM1	associated_with	gene	0.60
IL6	activates	gene	0.60

Incoming (71)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CXCL12	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
TET2	activates	gene	0.70
DDX5	regulates	gene	0.70
AGING	activates	gene	0.60
AND	associated_with	gene	0.60
GENES	activates	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
HUB GENES	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
SERPINE1	inhibits	gene	0.60
LAMP1	activates	gene	0.60
ARSA	activates	gene	0.60
LAMP2	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
IL-6	activates	gene	0.60
AND	activates	gene	0.60
CCL3	inhibits	gene	0.60
RAB27A	inhibits	gene	0.60
MTNR1A	associated_with	gene	0.60
NPY	associated_with	gene	0.60
C3AR1	associated_with	gene	0.60
CCR5	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
CNR2	associated_with	gene	0.60
ADCY2	associated_with	gene	0.60
GRM2	associated_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
CCL2	activates	gene	0.60
ASC	activates	gene	0.60
CAT	activates	gene	0.60
DIABETES MELLITUS	inhibits	gene	0.60
CANCER	associated_with	gene	0.60
CCL2	interacts_with	gene	0.60
CCL2	regulates	gene	0.60
CXCR4	interacts_with	gene	0.60
SGK1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
A2M	associated_with	gene	0.60
AQP4	associated_with	gene	0.60
TNF	associated_with	gene	0.60
P2RX7	associated_with	gene	0.60
ISG15	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
USP18	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CXCL12 in their description or question text

No additional research found