gene

USP18

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about USP18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

7Outgoing

10Incoming

0Experiments

0Debates

Summary

OTULIN — OTU Deubiquitinase with Linear Linkage Specificity

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🧬 Gene Info

Gene Symbol	OTULIN
Full Name	OTU Deubiquitinase with Linear Linkage Specificity
Chromosome	5p15.2
Protein Type	Protease
Function	Unlike other OTU family members, OTULIN shows exceptional specificity for linear ubiquitin chains and does not efficiently cleave other ubiquitin linkage types.
Pathways	NF-κB signaling, NF-κB Signaling, NF-κB
Ensembl ID	ENSG00000135547
GeneCards	OTULIN
Human Protein Atlas	OTULIN
Alzheimer's Disease	OTULIN regulates tau expression through linear ubiquitin-dependent mechanisms. Dysregulation of OTULIN may contribute to tau pathology in AD. [@ref]
Parkinson's Disease	Implicated in PD pathogenesis through regulation of protein quality control pathways
Amyotrophic Lateral Sclerosis (ALS)	Rare variants may modify ALS risk through effects on proteostasis
Immunodeficiency	Loss-of-function mutations cause OTULIN-related immunodeficiency and inflammatory disease
Cancer	Altered expression in various cancers, affecting cell proliferation and survival
Associated Diseases	Infection, Inflammation
Interactions	IKBKG, INFLAMMATION, MITOCHONDRIA, NFKB, NF-ΚB, PINK1
KG Connections	38 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

OTULIN — OTU Deubiquitinase with Linear Linkage Specificity

gene · 704 words

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Pathway Diagram

graph TD
    USP18["USP18"]
    Als{"Als"}
    USP18 -->|"associated with"| Als
    Ms{"Ms"}
    USP18 -->|"associated with"| Ms
    Depression{"Depression"}
    USP18 -->|"associated with"| Depression
    Inflammation{"Inflammation"}
    USP18 -->|"associated with"| Inflammation
    CXCL12["CXCL12"]
    USP18 -->|"associated with"| CXCL12
    neurodegeneration["neurodegeneration"]
    USP18 -->|"implicated in"| neurodegeneration
    SGK1["SGK1"]
    SGK1 -->|"associated with"| USP18
    FKBP5["FKBP5"]
    FKBP5 -->|"associated with"| USP18
    A2M["A2M"]
    A2M -->|"associated with"| USP18
    AQP4["AQP4"]
    AQP4 -->|"associated with"| USP18
    TNF["TNF"]
    TNF -->|"associated with"| USP18
    P2RX7["P2RX7"]
    P2RX7 -->|"associated with"| USP18
    ISG15["ISG15"]
    ISG15 -->|"associated with"| USP18
    STAT1["STAT1"]
    STAT1 -->|"associated with"| USP18
    style USP18 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:USP18	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Als	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Depression	associated_with	disease	0.65
CXCL12	associated_with	gene	0.60

Incoming (10)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:USP18	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
SGK1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
A2M	associated_with	gene	0.60
AQP4	associated_with	gene	0.60
TNF	associated_with	gene	0.60
P2RX7	associated_with	gene	0.60
ISG15	associated_with	gene	0.60
STAT1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning USP18 in their description or question text

No additional research found