gene

ISG15

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ISG15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

273Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Comprehensive page for ISG15 gene encoding an ubiquitin-like protein involved in neuroinflammation and protein quality control

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🧬 Gene Info

Gene Symbol	ISG15
Full Name	Interferon-Stimulated Gene 15
Chromosome	1p36.33
Function	is a ubiquitin-like protein that is induced by type I interferons (IFN-α/β) and plays a critical role in the innate immune response.
Amino Acids	165 aa
Exons	2
Pathways	Akt, Autophagy, Lipid Metabolism, Mapk, Pi3K
UniProt ID	[P51959](https://www.uniprot.org/uniprot/P51959)
Ensembl ID	ENSG00000187608
OMIM	607117
GeneCards	ISG15
Human Protein Atlas	ISG15
Associated Diseases	Als, Alzheimer Disease, Cancer, Cognitive Deficits, Depression, Inflammation
Interactions	AKT, ALZHEIMER, ALZHEIMER DISEASE, AND, ASC, ASK1
KG Connections	273 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ISG15 — Interferon-Stimulated Gene 15

gene · 1513 words

→

ISG15 Protein — Interferon-Stimulated Gene 15

protein · 603 words

→

Pathway Diagram

graph TD
    ISG15["ISG15"]
    ISG15 -->|"participates in"| INTERFERON_RESPONSE["INTERFERON_RESPONSE"]
    ISG15 -->|"regulates"| Als["Als"]
    ISG15 -->|"activates"| Aging["Aging"]
    ISG15 -->|"activates"| Cancer["Cancer"]
    ISG15 -->|"activates"| Alzheimer["Alzheimer"]
    ISG15 -->|"regulates"| Ataxia["Ataxia"]
    ISG15 -->|"activates"| Ms["Ms"]
    ISG15 -->|"activates"| Inflammation["Inflammation"]
    ISG15 -->|"regulates"| ALS["ALS"]
    ISG15 -->|"activates"| STAT1["STAT1"]
    CSF2["CSF2"] -->|"regulates"| ISG15
    NAMPT["NAMPT"] -->|"regulates"| ISG15
    FGF2["FGF2"] -->|"regulates"| ISG15
    CXCL10["CXCL10"] -->|"activates"| ISG15
    HSPA1A["HSPA1A"] -->|"regulates"| ISG15
    FGF8["FGF8"] -->|"regulates"| ISG15
    TLR4["TLR4"] -->|"regulates"| ISG15
    P38["P38"] -->|"regulates"| ISG15
    ERK["ERK"] -->|"regulates"| ISG15
    PI3K["PI3K"] -->|"regulates"| ISG15

Outgoing (182)

Target	Relation	Type	Str
Autophagy	inhibits	process	0.95
Alzheimer Disease	implicated_in	disease	0.95
Autophagy-Lysosomal Pathway	regulates	pathway	0.95
Autophagosome-Lysosome Fusion	inhibits	process	0.95
HDAC6	inhibits	gene	0.95
HDAC6	binds	gene	0.90
Synaptic Damage	mediates	phenotype	0.90
Cognitive Deficits	causes	phenotype	0.90
MAPT	promotes	gene	0.90
Selective Autophagy	regulates	process	0.85
Als	regulates	disease	0.75
Inflammation	activates	disease	0.75
INTERFERON_RESPONSE	participates_in	pathway	0.72
Autophagy	activates	pathway	0.70
Pi3K/Akt	regulates	pathway	0.70
AKT	regulates	gene	0.70
Diabetes	regulates	disease	0.65
Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Pancreatic Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Ataxia	regulates	disease	0.65
Ms	activates	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	inhibits	disease	0.65
Als	activates	disease	0.65
Encephalitis	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
ALS	regulates	disease	0.65
FAS	regulates	gene	0.60
TLR7	associated_with	gene	0.60
AURKA	associated_with	gene	0.60
STAT3	activates	gene	0.60
TAU	activates	gene	0.60
UBIQUITIN	regulates	gene	0.60
HDAC6	activates	gene	0.60
CDK5R2	therapeutic_target	gene	0.60
GRM5	therapeutic_target	gene	0.60
IRF3	activates	gene	0.60
HERC5	regulates	gene	0.60
PARKIN	regulates	gene	0.60
HERC5	activates	gene	0.60
DRP1	activates	gene	0.60
TRIM25	regulates	gene	0.60
Rb	therapeutic_target	protein	0.60
SNAP23	activates	gene	0.60

Incoming (91)

Source	Relation	Type	Str
MAPT	upregulates	gene	0.95
MAPT	inhibits	gene	0.70
IFN	expresses	gene	0.70
CDK5R2	associated_with	gene	0.60
FGF13	associated_with	gene	0.60
GRM5	associated_with	gene	0.60
MITOPHAGY	inhibits	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
CANCER	associated_with	gene	0.60
MFN1	activates	gene	0.60
SCN2B	associated_with	gene	0.60
PARKIN	activates	gene	0.60
STAT1	associated_with	gene	0.60
SLC17A7	therapeutic_target	gene	0.60
SCN8A	therapeutic_target	gene	0.60
STAT1	therapeutic_target	gene	0.60
SCN2B	therapeutic_target	gene	0.60
HERC5	therapeutic_target	gene	0.60
HDAC6	inhibits	gene	0.60
GAPDH	regulates	gene	0.60
HDAC6	regulates	gene	0.60
AKT	activates	gene	0.60
ASC	activates	gene	0.60
ATF3	activates	gene	0.60
ATG5	activates	gene	0.60
CCR2	activates	gene	0.60
CHOP	activates	gene	0.60
IRAK1	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
EPO	regulates	gene	0.60
CYTOKINES	inhibits	gene	0.60
IL-4	inhibits	gene	0.60
IL-13	inhibits	gene	0.60
GENES	associated_with	gene	0.60
ASK1	activates	gene	0.60
ERK	activates	gene	0.60
GRM5	targets	gene	0.60
FGF13	targets	gene	0.60
CDK5R2	targets	gene	0.60
CSF2	regulates	gene	0.60
NAMPT	regulates	gene	0.60
FGF2	regulates	gene	0.60
CXCL10	activates	gene	0.60
HSPA1A	regulates	gene	0.60
FGF8	regulates	gene	0.60
TLR4	regulates	gene	0.60
HDAC6	activates	gene	0.60
UBIQUITIN	regulates	gene	0.60
TAU	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ISG15 in their description or question text

No additional research found