| Gene Symbol | CXCL12 |
| Aliases | CXCL12PROTEIN |
| Protein Type | Gene |
| Function | CXCL12 is a highly conserved chemokine expressed throughout the central nervous system. |
| Primary Expression | the brain: - Neurons: High expression in cortex, hippocampus, cerebell |
| Subcellular Localization | Secreted, cell surface |
| Pathways | Apoptosis, Autophagy, Cell Cycle, Chaperone, Epigenetic |
| UniProt ID | P48061 |
| GeneCards | CXCL12 |
| Human Protein Atlas | CXCL12 |
| Size | 99 amino acids (mature peptide is 68 amino acids after signal peptide cleavage) |
| Structure | Belongs to the CXC chemokine fold with a flexible N-terminus, three anti-parallel beta strands, and a C-terminal alpha helix |
| Receptor binding | The N-terminal region is critical for receptor activation, while the central region interacts with the receptor extracellular domains |
| Glycosylation | Can be glycosylated, affecting its stability and activity |
| Neuronal migration | CXCL12/CXCR4 signaling guides the migration of GABAergic interneurons during cortical development[@stumm2003] |
| Associated Diseases | Als, Alzheimer, Cancer, Carcinoma, Depression |
| Interactions | adcy2, ADCY2, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AND |
| SciDEX Hypotheses | CCL2 Gradient Disruption via Astrocytic CXCL12 Upr |
| KG Connections | 180 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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