gene

adcy2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about adcy2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

30Outgoing

17Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	ADCY2
Full Name	Adenylate Cyclase 2
Chromosome	5p15.2
Protein Type	Enzyme
Function	is a membrane-bound enzyme that catalyzes the conversion of ATP to cyclic adenosine monophosphate (cAMP), a crucial second messenger in cellular signaling.
Subcellular Localization	ADCY2 is localized to:
Molecular Weight	125 kDa
UniProt ID	[Q08462](https://www.uniprot.org/uniprot/Q08462)
Ensembl ID	ENSG00000045081
OMIM	103070
GeneCards	ADCY2
Human Protein Atlas	ADCY2
N-terminal regulatory domain	Contains calmodulin-binding sites for calcium regulation
Membrane-spanning helices	12 transmembrane domains organized in 6 pairs (M1-M6)
Cytoplasmic catalytic domains	Two large cytoplasmic loops (C1 and C2) form the active site
Associated Diseases	Alzheimer's disease (AD
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, C3AR1, CCR5, CNR2, CXCL12
KG Connections	40 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ADCY2 — Adenylate Cyclase 2

gene · 1396 words

→

Pathway Diagram

graph TD
    ADCY2["ADCY2"]
    ADCY2 -->|"interacts"| Alzheimer["Alzheimer"]
    ADCY2 -->|"interacts"| Als["Als"]
    ADCY2 -->|"interacts"| ALS["ALS"]
    ADCY2 -->|"interacts"| ALZHEIMER["ALZHEIMER"]
    ADCY2 -->|"expressed in"| CYTOKINES["CYTOKINES"]
    ADCY2 -->|"expressed in"| App["App"]
    ADCY2 -->|"interacts"| MTNR1A["MTNR1A"]
    ADCY2 -->|"interacts"| CNR2["CNR2"]
    ALZHEIMER -->|"interacts"| ADCY2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"interacts"| ADCY2
    GRM1["GRM1"] -->|"regulates"| ADCY2
    CCR8["CCR8"] -->|"regulates"| ADCY2
    P2RY13["P2RY13"] -->|"regulates"| ADCY2

Outgoing (30)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ADCY2	data_in	dataset_row	0.00
ALS	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
CXCL8	associated_with	gene	0.60
CCR5	associated_with	gene	0.60
MTNR1A	associated_with	gene	0.60
CNR2	associated_with	gene	0.60
C3AR1	associated_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
GRM2	associated_with	gene	0.60
NPY	associated_with	gene	0.60
CYTOKINES	expressed_in	gene	0.60
App	expressed_in	protein	0.60
C3AR1	interacts_with	gene	0.60
CCR5	interacts_with	gene	0.60
CNR2	interacts_with	gene	0.60
CXCL12	interacts_with	gene	0.60
CXCL12	associated_with	gene	0.60
GRM2	interacts_with	gene	0.60
MTNR1A	interacts_with	gene	0.60
NPY	interacts_with	gene	0.60
CXCL8	interacts_with	gene	0.60
MTNR1A	interacts_with	gene	0.50
CNR2	interacts_with	gene	0.50
CCR5	interacts_with	gene	0.50
CXCL8	interacts_with	gene	0.50
C3AR1	interacts_with	gene	0.50
GRM2	interacts_with	gene	0.50
CXCL12	interacts_with	gene	0.50

Incoming (17)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ADCY2	data_in	dataset_row	0.00
GRM2	associated_with	gene	0.60
GRM1	regulates	gene	0.60
CCR8	regulates	gene	0.60
P2RY13	regulates	gene	0.60
CXCL12	associated_with	gene	0.60
MTNR1A	associated_with	gene	0.60
NPY	associated_with	gene	0.60
C3AR1	associated_with	gene	0.60
CCR5	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
CNR2	associated_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
HUB GENES	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning adcy2 in their description or question text

No additional research found