protein

BNIP3L

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BNIP3L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1010Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

BNIP3L is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 517 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BNIP3L
Full Name	BCL2 Interacting Protein 3 Like (NIX)
Chromosome	8p21.2
Function	Mitochondrial recruitment: Being anchored to the mitochondrial outer membrane, BNIP3L clusters at sites of autophagosome initiation
Primary Expression	Cerebral cortex, Mitochondria, Substantia nigra
Pathways	Adaptive Immunity, Apoptosis, Autophagy, Epigenetic, Immune Response
UniProt ID	O60238
NCBI Gene ID	665
OMIM	603588
GeneCards	BNIP3L
Human Protein Atlas	BNIP3L
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Interactions	ABCD3, ADORA2A, AGING, ALS, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	1006 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BNIP3L — AlphaFold O60238 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BNIP3L — BCL2 Interacting Protein 3 Like (NIX)

gene · 738 words

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BNIP3L Protein

protein · 711 words

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Pathway Diagram

flowchart TD
    BNIP3L(["BNIP3L"])
    Mitophagy["Mitophagy"]
    MITOPHAGY_RECEPTOR["MITOPHAGY RECEPTOR"]
    PROTEASOMES["PROTEASOMES"]
    mitophagy["mitophagy"]
    Damaged_Mitochondria("Damaged Mitochondria")
    Als["Als"]
    Proteasome["Proteasome"]
    Mitochondrial_Damage("Mitochondrial Damage")
    Autophagy["Autophagy"]
    MITOPHAGY(["MITOPHAGY"])
    NIX(["NIX"])
    Cancer["Cancer"]

    BNIP3L -->|"involved in"| Mitophagy
    BNIP3L -->|"associated with"| MITOPHAGY_RECEPTOR
    PROTEASOMES -.->|"degrades"| BNIP3L
    BNIP3L -->|"participates in"| mitophagy
    BNIP3L -->|"targets"| Damaged_Mitochondria
    BNIP3L -->|"mediates"| Mitophagy
    BNIP3L -->|"regulates"| Als
    Proteasome -.->|"degrades"| BNIP3L
    BNIP3L -->|"protects against"| Mitochondrial_Damage
    BNIP3L -->|"regulates"| Autophagy
    MITOPHAGY -->|"regulates"| BNIP3L
    NIX -->|"regulates"| BNIP3L
    BNIP3L -->|"regulates"| Cancer
    BNIP3L -->|"activates"| Mitophagy
    BNIP3L -->|"regulates"| Mitophagy

    style BNIP3L fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (660)

Target	Relation	Type	Str
BNIP3L	encodes	protein	0.00
Mitophagy	associated_with	process	0.95
MITOPHAGY RECEPTOR	associated_with	receptor	0.95
Damaged Mitochondria	targets	phenotype	0.90
Mitophagy Deficiency	involved_in	phenotype	0.90
Mitophagy	mediates	process	0.90
Cerebral Ischemia	protects_against	disease	0.90
mitophagy	participates_in	pathway	0.90
cerebral ischemic injury	protects_against	disease	0.87
Als	regulates	disease	0.85
neuronal survival	promotes	phenotype	0.85
autophagy pathway	participates_in	pathway	0.80
Mitochondrial Damage	protects_against	process	0.80
Mitochondria	interacts_with	cell_type	0.80
Autophagy	regulates	pathway	0.80
Cancer	regulates	disease	0.75
PARKIN	regulates	gene	0.70
Mitophagy	regulates	pathway	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
Mitophagy	activates	pathway	0.70
Alzheimer's disease	regulates	disease	0.70
oxidative stress response	participates_in	pathway	0.70
Neurodegeneration	interacts_with	disease	0.65
Senescence	activates	disease	0.65
Als	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Ischemia	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Ischemia	activates	disease	0.65
Ms	activates	disease	0.65
Diabetes	regulates	disease	0.65
Tumor	activates	disease	0.65
Cardiac	activates	disease	0.65
Aging	activates	disease	0.65
ALS	interacts_with	disease	0.65
Aging	regulates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
Cardiac	regulates	disease	0.65
Als	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Heart Failure	regulates	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Aging	associated_with	disease	0.65
Dementia	interacts_with	disease	0.65

Incoming (350)

Source	Relation	Type	Str
BNIP3L	encodes	gene	0.00
PROTEASOMES	degrades	enzyme	0.95
h-2a4e4ad2	targets_gene	hypothesis	0.90
cerebral ischemia	causes	disease	0.90
NIX	regulates	gene	0.80
MITOPHAGY	regulates	gene	0.80
MITOCHONDRIA	associated_with	gene	0.70
AUTOPHAGY	regulates	gene	0.70
MITOCHONDRIA	regulates	gene	0.70
P62	regulates	gene	0.70
SQSTM1	regulates	gene	0.70
CANCER	regulates	gene	0.70
ATG	activates	gene	0.60
ATP	activates	gene	0.60
ALS	regulates	gene	0.60
AMPK	regulates	gene	0.60
ATG	regulates	gene	0.60
ATP	regulates	gene	0.60
BCL2	protects_against	gene	0.60
RIP3	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
NR4A1	associated_with	gene	0.60
RIPK2	associated_with	gene	0.60
TUFM	associated_with	gene	0.60
BCL2L11	activates	entity	0.60
BCL2L13	activates	entity	0.60
ATG7	protects_against	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
ATP	inhibits	gene	0.60
ROS	associated_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between neurons and glia

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Mitochondrial transfer between neurons and glia?

closed · Rounds: 4 · Score: 0.71 · 2026-04-12

Analysis question not specified

closed · Rounds: 4 · Score: 0.81 · 2026-04-06

Related Research

Hypotheses and analyses mentioning BNIP3L in their description or question text

No additional research found