concept

NEURONAL SURVIVAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEURONAL SURVIVAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

52Connections

1Hypotheses

0Analyses

1Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	NEURONAL SURVIVAL

Pathway Diagram

graph TD
    NEURONAL_SURVIVAL["NEURONAL SURVIVAL"]
    Calcium_Homeostasis["Calcium Homeostasis"] -->|"regulates"| NEURONAL_SURVIVAL
    NEUROTROPHINS["NEUROTROPHINS"] -->|"regulates"| NEURONAL_SURVIVAL
    A1_Astrocytes["A1 Astrocytes"] -->|"downregulates"| NEURONAL_SURVIVAL
    Mitochondrial_Quality_Control["Mitochondrial Quality Control"] -->|"regulates"| NEURONAL_SURVIVAL
    BDNF["BDNF"] -->|"promotes"| NEURONAL_SURVIVAL
    Glycophagy["Glycophagy"] -.protects against.-> NEURONAL_SURVIVAL
    IGF1R["IGF1R"] -->|"regulates"| NEURONAL_SURVIVAL
    Pi3K_Akt["Pi3K/Akt"] -->|"activates"| NEURONAL_SURVIVAL

Outgoing (1)

Target	Relation	Type	Str
post-stroke functional recovery	promotes	phenotype	0.88

Incoming (51)

Source	Relation	Type	Str
NEUROTROPHINS	regulates	protein	0.95
Inflammatory Cytokines	downregulates	process	0.95
Mitophagy	associated_with	process	0.95
Calcium Homeostasis	regulates	process	0.95
BDNF	mediates	protein	0.92
Neurotrophins	promotes	protein	0.90
Mitochondrial Quality Control	regulates	process	0.90
Cldn5 Gene Augmentation	promotes	mechanism	0.90
BDNF	promotes	protein	0.90
amyloid-beta	suppresses	compound	0.90
NPFF	associated_with	protein	0.90
A1 Astrocytes	downregulates	phenotype	0.90
Glycophagy	protects_against	process	0.89
Microglia	promotes	cell_type	0.88
Mitochondrial Dysfunction	inhibits	process	0.87
PSEN1	involved_in	protein	0.85
BDNF	activates	protein	0.85
Autophagy	promotes	pathway	0.85
BDNF	activates	protein	0.85
LL-37	inhibits	protein	0.85
Serotonin	promotes	compound	0.85
Cytokines	promotes	protein	0.85
A1 Reactive Astrocytes	inhibits	phenotype	0.85
TNF	inhibits	protein	0.85
BDNF	associated_with	protein	0.85
Pi3K/Akt	activates	pathway	0.85
engineered macrophage-derived biohybrid nanoplatform	promotes	drug	0.85
BDNF	mediates	entity	0.85
TNF-α	inhibits	protein	0.85
Bnip3L	promotes	protein	0.85
APOE	promotes	protein	0.80
CASP3	regulates	protein	0.80
LL-37	downregulates	protein	0.80
IGF1R	regulates	gene	0.80
BDNF	regulates	gene	0.80
LC3	promotes	protein	0.80
Neurotrophic factors	promotes	compound	0.80
IL-6	promotes	protein	0.80
blood-retinal barrier integrity	promotes	phenotype	0.80
ERK	promotes	protein	0.75
DJ1	involved_in	protein	0.75
mitophagy	activates	process	0.70
BMAL1	activates	protein	0.70
BCL2	activates	protein	0.70
TrkB-FL	regulates	protein	0.70
PI3K/AKT	activates	pathway	0.70
PI3K-AKT	activates	pathway	0.70
PI3K/AKT	regulates	pathway	0.70
neurotrophic factors	activates	protein	0.70
PARKIN	activates	protein	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Heterogeneous astrocyte activation states differentially imp	0.640	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
iPSC-NPC effects on astrocytes in vitro ICH model	exploratory	intracerebral hemorrhage	0.900	0.00	in vitro ICH cell culture mode	proposed	N/A

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Brain atrophy patterns in anti-IgLON5 disease. [PMID:40650880]	Yogeshwar SM, Bartels F, Grüter T, Muñiz	Brain	2026
Potential diagnostic markers in Alzheimer's disease: current perspectives and fu [PMID:40911035]	Zheng M, Wang S, Jia J	Neurodegener Dis Manag	2026
Kidney Function, Alzheimer Disease Blood Biomarkers, and Dementia Risk in Commun [PMID:41337685]	Gasparini F, Valletta M, Vetrano DL, Ber	Neurology	2026
The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736]	Abedin MJ, Kastanenka KV	J Alzheimers Dis	2026
Biomarker-integrated prognostic stagings for Alzheimer's Disease. [PMID:41622252]	Shin D, Lee S, Kim JP, Jang H, Yun J et	Nat Commun	2026
Prognostic Value of Plasma NfL and GFAP for Conversion to Alzheimer's Disease an [PMID:41703957]	Özkurt Ç, Kelicen-Uğur P	Biomarkers	2026
From scaffold to effector: reframing GFAP in neurodegeneration. [PMID:41775321]	Lu YH, Zhu XP, Li S, Zhang FN, Cai CB et	J Adv Res	2026
Translating neurofilament light chain testing into clinical practice: a multidis [PMID:41831326]	Furlan R, Di Sapio A, Ferraro D, Rossi E	Clin Chem Lab Med	2026
Role of astrocyte biomarker GFAP in early diagnosis and prognosis assessment of [PMID:41850459]	Li S, Wei S, Wang L, Yu T, Wang H et al.	Int J Biol Macromol	2026
Impaired glymphatic function is associated with synaptic loss in cognitive impai [PMID:41454064]	He K, Wang J, Wu J, Chen X, Chen H, Li J	European journal of nuclear me	2026
Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation. [PMID:41376284]	Xie XY, Wang L, Xie SQ, Zhou GF, Wen QX,	Autophagy	2026
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEURONAL SURVIVAL in their description or question text

No additional research found