gene 1,159 words KG: BMP4
Contents

BMP4 Gene (Bone Morphogenetic Protein 4)

🧬 Gene Info
Gene SymbolBMP4
Functionencodes a member of the TGF-beta superfamily of signaling molecules.
Molecular Weight47 kDa
Amino Acids116 aa
PathwaysMAPK Pathway, PI3K, TGF-β
Ensembl IDENSG00000109475
GeneCardsBMP4
Human Protein AtlasBMP4
Signal peptide cleavageN-terminal targeting sequence removed
Prodomain removalCleavage to generate active mature protein
Dimer formationActive form is a homodimer (or heterodimer with BMP2)
Associated DiseasesALZHEIMER'S DISEASE, Cancer, Carcinoma, Ms, Tumor
InteractionsAND, APOE4, BMP7, HEDGEHOG, MICROGLIA, TGFB2
KG Connections46 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38

Related Analyses (11)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (13)

Apoptosis in Neurodegeneration
entity · KG edge: therapeutic_target
Genes
index · KG edge: associated_with
BMP2 — Bone Morphogenetic Protein 2
gene · KG edge: associated_with
BMP7 Gene (Bone Morphogenetic Protein 7)
gene · KG edge: activates
CDKN2B
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TGFBR2 associated_with BMP4
BMP4 associated_with MYC
BMP4 associated_with E2F5
BMP4 associated_with CDKN2B
BMP4 activates TGFBR1
BMP4 associated_with BMP2
BMP4 activates TGFB2
BMP4 activates BMP7
MICROGLIA interacts_with BMP4
BMP2 associated_with BMP4

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