gene

ATP13A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP13A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

427Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Gene profile: ATP13A2/PARK9 — lysosomal ATPase linked to Kufor-Rakeb syndrome and Parkinson's disease

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🧬 Gene Info

Gene Symbol	ATP13A2
Full Name	ATPase Cation Transporting 13A2 (PARK9)
Aliases	ATPase Cation Transporting 13A2
Chromosome	1p36.13
Protein Type	Protein
Function	is a member of the P-type ATPase family that functions as a lysosomal cation transporter, primarily pumping manganese and other cations across the lysosomal membrane[@ramirez2006].
Primary Expression	Substantia nigra, Basal ganglia, Cerebral cortex
Subcellular Localization	Lysosomes, Late endosomes
Molecular Weight	446 kDa
Amino Acids	978 aa
Pathways	Autophagy
UniProt ID	Q9BYU8
Ensembl ID	ENSG00000159363
GeneCards	ATP13A2
Human Protein Atlas	ATP13A2
Associated Diseases	aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis
Interactions	Alpha-Synuclein, ALS, AMYLOID, AND, ATXN2, CP
KG Connections	427 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ATP13A2 — AlphaFold Q9BYU8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    ATP13A2["ATP13A2"] -->|"associated with"| Parkinson_s_disease["Parkinson's disease"]
    ATP13A2["ATP13A2"] -->|"therapeutic target"| Ms["Ms"]
    ATP13A2["ATP13A2"] -->|"therapeutic target"| Parkinson["Parkinson"]
    ATP13A2["ATP13A2"] -->|"activates"| Parkinson["Parkinson"]
    ATP13A2["ATP13A2"] -->|"expressed in"| Parkinson["Parkinson"]
    ATP13A2["ATP13A2"] -->|"therapeutic target"| GAIN["GAIN"]
    ATP13A2["ATP13A2"] -->|"therapeutic target"| LRRK2["LRRK2"]
    ATP13A2["ATP13A2"] -->|"therapeutic target"| PRKN["PRKN"]
    ATP13A2["ATP13A2"] -->|"therapeutic target"| PINK1["PINK1"]
    ATP13A2["ATP13A2"] -->|"associated with"| LRRK2["LRRK2"]
    ATP13A2["ATP13A2"] -->|"associated with"| PINK1["PINK1"]
    ATP13A2["ATP13A2"] -->|"associated with"| PRKN["PRKN"]
    style ATP13A2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Parkinson_s_disease fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style GAIN fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style LRRK2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style PRKN fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style PINK1 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (326)

Target	Relation	Type	Str
Mitochondrial Homeostasis	modulates	process	0.90
Polyamine Homeostasis	regulates	process	0.90
NLRP3	inhibits	protein	0.90
neurons	expressed_in	cell_type	0.90
Autophagy	involved_in	process	0.85
PINK1	interacts_with	gene	0.80
DNAJC6	interacts_with	gene	0.80
Parkinson's disease	causes	disease	0.80
Parkinson's disease	associated_with	disease	0.80
FBXO7	interacts_with	gene	0.80
SYNJ1	interacts_with	gene	0.80
PRKN	interacts_with	gene	0.80
LRRK2	expressed_in	gene	0.70
PARK7	causes	gene	0.70
DOPAMINERGIC	associated_with	cell_type	0.70
NEURONS	mediates	cell_type	0.70
GSK3B	associated_with	gene	0.70
LRRK2	causes	gene	0.70
STING	activates	gene	0.70
SNCA	causes	gene	0.70
PINK1	causes	gene	0.70
PARKINSON	associated_with	gene	0.70
PRKN	associated_with	gene	0.70
Lysosomal Polyamine Export	regulates	biological_process	0.70
SNCA	interacts_with	gene	0.70
neuroinflammation	associated_with	disease	0.70
VPS13C	interacts_with	gene	0.70
LRRK2	interacts_with	gene	0.70
neurodegeneration	causes	disease	0.70
VPS13C	associated_with	gene	0.70
oxidative stress response	participates_in	pathway	0.70
ALS	associated_with	disease	0.70
GBA1	interacts_with	gene	0.70
PARK7	interacts_with	gene	0.70
OPTN	co_discussed	gene	0.65
MAPT	co_discussed	gene	0.65
GSK3B	co_discussed	gene	0.65
autophagy	co_discussed	concept	0.65
NEURODEGENERATION	produces	disease	0.65
neurodegeneration	co_discussed	concept	0.65
neuron	co_discussed	concept	0.65
FBXO7	co_discussed	gene	0.65
PARKINSON'S DISEASE	activates	disease	0.65
PARK7	associated_with	gene	0.65
SMPD1	co_discussed	gene	0.65
NLRP3	co_discussed	gene	0.65
Neurodegeneration	regulates	disease	0.65
Dementia	associated_with	disease	0.65
Dementia	regulates	disease	0.65
Als	regulates	disease	0.65

Incoming (101)

Source	Relation	Type	Str
ABCA7	co_discussed	gene	0.65
GLIOSIS	activates	phenotype	0.65
OXIDATIVE STRESS	inhibits	gene	0.60
AND	associated_with	gene	0.60
LYSOSOME	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
LYSOSOME	activates	gene	0.60
AND	activates	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
ALPHA-SYNUCLEIN	co_discussed	gene	0.60
ALS	associated_with	gene	0.60
ATXN2	activates	gene	0.60
LRRK2	activates	gene	0.60
GBA	inhibits	gene	0.60
PARKIN	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.60
ACHE	causes	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
DJ-1	expressed_in	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
NEUROTOXICITY	protects_against	gene	0.60
MITOCHONDRIAL DYSFUNCTION	protects_against	gene	0.60
PARKINSON	protects_against	gene	0.60
AUTOPHAGY	protects_against	gene	0.60
DJ-1	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
LRRK2	therapeutic_target	gene	0.60
PRKN	therapeutic_target	gene	0.60
ALPHA-SYNUCLEIN	therapeutic_target	gene	0.60
GRN	causes	gene	0.60
APOE	causes	gene	0.60
GCASE	activates	gene	0.60
PRKN	associated_with	gene	0.60
PRKN	expressed_in	gene	0.60
GAIN	expressed_in	gene	0.60
PINK1	expressed_in	gene	0.60
LRRK2	expressed_in	gene	0.60
GBA	associated_with	gene	0.60
C9ORF72	regulates	gene	0.60
GAIN	regulates	gene	0.60
TFEB	causes	gene	0.60
C9ORF72	causes	gene	0.60
TAU	causes	gene	0.60
GAIN	causes	gene	0.60
MAPT	causes	gene	0.60
APP	causes	gene	0.60
PARK7	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATP13A2 in their description or question text

No additional research found

ATP13A2

Understanding Entity Pages

Summary

Wiki Pages (8)

ATP13A2 — ATPase Cation Transporting 13A2

ATP13A2 Lysosomal Dysfunction Pathway in Parkinson's Disease

ATP13A2 (PARK9) Pathway in Parkinson's Disease

ATP13A2 Lysosomal Dysfunction Parkinson's Disease Causal Chain

ATP13A2/PARK9 Lysosomal Function Therapies for Parkinson's Disease

ATP13A2 (PARK9) Targeting for Parkinson's Disease

ATP13A2 Protein (PARK9)

PD ATP13A2/PARK9 Lysosomal Therapy Companies