concept

SOAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

263Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

SOAT1 is a concept in neurodegeneration research. Key relationships include: activates, interacts with, co discussed. Associated with Als, Alzheimer, Cancer. Connected to 68 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SOAT1
Key Genes/Proteins	ABCA1, abca2, ABCA2, ACAT1, Actin, ALZHEIMER
Related Diseases	Als, ALS, Alzheimer

🔮 Predicted Structure: SOAT1 — AlphaFold B1APM4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    SOAT1["SOAT1"]
    SOAT1 -->|"inhibits"| Zika_Virus_Infection["Zika Virus Infection"]
    SOAT1 -->|"involved_in"| Cholesterol_Ester_Biosynthesis["Cholesterol Ester Biosynthesis"]
    SOAT1 -->|"activates"| Cancer["Cancer"]
    SOAT1 -->|"activates"| Glioblastoma["Glioblastoma"]
    SOAT1 -->|"activates"| Tumor["Tumor"]
    SOAT1 -->|"activates"| Ms["Ms"]
    SOAT1 -->|"inhibits"| DGAT1["DGAT1"]
    h_7d4a24d3["h-7d4a24d3"] -->|"targets"| SOAT1
    GBM["GBM"] -->|"activates"| SOAT1
    DGAT1 -->|"inhibits"| SOAT1
    CD36["CD36"] -->|"activates"| SOAT1
    APOA1["APOA1"] -->|"activates"| SOAT1
    NR1H3["NR1H3"] -->|"activates"| SOAT1
    PLIN2["PLIN2"] -->|"activates"| SOAT1
    SPHK1["SPHK1"] -->|"interacts"| SOAT1
    LPCAT3["LPCAT3"] -->|"interacts"| SOAT1

Outgoing (144)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:SOAT1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
LIPID DROPLET STORAGE	regulates	entity	0.95
CHOLESTERYL ESTER SYNTHESIS	regulates	entity	0.95
ZIKA VIRUS INFECTION	inhibits	entity	0.95
CHOLESTEROL ESTER METABOLISM	regulates	entity	0.90
lipid droplet storage	upregulates	process	0.90
THERAPEUTIC_TARGET	therapeutic_target	entity	0.90
GLIOBLASTOMA	associated_with	entity	0.90
Blastocyst Formation	involved_in	process	0.90
Cell Differentiation	involved_in	process	0.90
LIPID METABOLISM	involved_in	entity	0.85
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Ms	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Cancer	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Atherosclerosis	degrades	disease	0.65
Alzheimer	degrades	disease	0.65
Als	degrades	disease	0.65
Alzheimer	transports	disease	0.65
Atherosclerosis	transports	disease	0.65
ALS	transports	disease	0.65
Stroke	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
SREBF1	transports	gene	0.60
APOC3	transports	gene	0.60
APOC2	transports	gene	0.60
CANCER	regulates	disease	0.60
MAPT	transports	gene	0.60
ABCA2	transports	gene	0.60
PSEN1	transports	gene	0.60
TAU	transports	gene	0.60
APOC1	transports	gene	0.60
LRP1	transports	gene	0.60
Apoptosis	expressed_in	pathway	0.60
Microglia	activates	cell_type	0.60
Actin	activates	protein	0.60
Erk	inhibits	protein	0.60
Ras	inhibits	protein	0.60
Ras	activates	protein	0.60

Incoming (119)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:SOAT1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
h-7d4a24d3	targets	hypothesis	0.80
ACAT1	inhibits	gene	0.70
DGAT1	associated_with	gene	0.60
GBM	protects_against	gene	0.60
ABCA2	activates	gene	0.60
APOC3	activates	gene	0.60
DGAT1	regulates	entity	0.60
CD36	regulates	entity	0.60
APOA1	regulates	entity	0.60
GBM	expressed_in	entity	0.60
DGAT1	expressed_in	entity	0.60
DGAT1 AND SOAT1	inhibits	gene	0.60
GBM	activates	gene	0.60
AND	interacts_with	gene	0.60
POR	interacts_with	gene	0.60
RNA	inhibits	gene	0.60
AND	inhibits	gene	0.60
AND	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
CANCER	activates	gene	0.60
RNA	expressed_in	gene	0.60
CH25H	activates	gene	0.60
TFCP2	transports	gene	0.60
APOE3	inhibits	gene	0.60
ALZHEIMER	degrades	gene	0.60
PLIN2	regulates	entity	0.60
NR1H3	regulates	entity	0.60
DGAT1	protects_against	gene	0.60
ACAT1	expressed_in	gene	0.60
STROKE	expressed_in	gene	0.60
RIPK1	interacts_with	gene	0.60
LDLR	causes	gene	0.60
DGAT1	inhibits	gene	0.60
DGAT1	activates	gene	0.60
CD36	activates	gene	0.60
APOA1	activates	gene	0.60
SPHK1	interacts_with	gene	0.60
GPX4	interacts_with	gene	0.60
LRP8	activates	gene	0.60
MAPT	regulates	gene	0.60
LRP1	interacts_with	gene	0.60
LIPA	regulates	gene	0.60
APP	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
CYP46A1	activates	gene	0.60
ABCA1	activates	gene	0.60
NCSTN	regulates	gene	0.60
GSK3B	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Astrocyte reactivity subtypes in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.741

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Astrocyte reactivity subtypes in neurodegeneration

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning SOAT1 in their description or question text

No additional research found