concept

PTGS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTGS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

29Outgoing

28Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PTGS1
Key Genes/Proteins	ACAT1, ALDH2, ALOX12, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
Related Diseases	Als, ALS, Alzheimer
Related Pathways	Amyloid

Pathway Diagram

graph TD
    PTGS1["PTGS1"]
    PTGS1 -->|"inhibits"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    PTGS1 -->|"regulates"| platelet_aggregation["platelet aggregation"]
    PTGS1 -->|"activates"| Alzheimer["Alzheimer"]
    PTGS1 -->|"activates"| Als["Als"]
    PTGS1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    PTGS1 -->|"inhibits"| Ischemia["Ischemia"]
    PTGS1 -->|"inhibits"| Stroke["Stroke"]
    DZSM["DZSM"] -->|"regulates"| PTGS1
    AMPK["AMPK"] -->|"activates"| PTGS1
    NGF["NGF"] -->|"regulates"| PTGS1
    PPARG["PPARG"] -->|"activates"| PTGS1
    ALZHEIMER["ALZHEIMER"] -->|"activates"| PTGS1
    PRKAA1["PRKAA1"] -->|"activates"| PTGS1
    LDLR["LDLR"] -->|"regulates"| PTGS1
    APP_PS1["APP/PS1"] -->|"regulates"| PTGS1

Outgoing (29)

Target	Relation	Type	Str
platelet aggregation	regulates	process	0.70
Alzheimer	activates	disease	0.65
ALS	activates	disease	0.65
Ischemia	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
Stroke	inhibits	disease	0.65
Als	activates	disease	0.65
Als	regulates	disease	0.65
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
Cholesterol Metabolism	activates	pathway	0.60
Amyloid	activates	pathway	0.60
PRKAA1	activates	gene	0.60
APP/PS1	regulates	gene	0.60
LDLR	regulates	gene	0.60
Cytokine	regulates	protein	0.60
Ngf	regulates	protein	0.60
AMPK	activates	gene	0.60
PPARG	activates	gene	0.60
NGF	regulates	gene	0.60
App	regulates	protein	0.60
PTGS2	associated_with	gene	0.60
LDL	regulates	gene	0.60
POMC	activates	gene	0.60
Lipid Metabolism	activates	pathway	0.60
Cholesterol	activates	pathway	0.60
CTSB	regulates	gene	0.60
CTSD	regulates	gene	0.60
Neuron	regulates	cell_type	0.60

Incoming (28)

Source	Relation	Type	Str
DZSM	regulates	drug	0.70
STROKE	inhibits	gene	0.60
LDHA	regulates	gene	0.60
ALDH2	regulates	gene	0.60
TARDBP	regulates	gene	0.60
ROS	inhibits	gene	0.60
ACAT1	regulates	gene	0.60
LGALS1	regulates	gene	0.60
FASN	regulates	gene	0.60
CDK1	regulates	gene	0.60
ALOX12	associated_with	gene	0.60
AR	associated_with	gene	0.60
HO1	associated_with	gene	0.60
P2RY1	associated_with	gene	0.60
PON1	associated_with	gene	0.60
AMPK	activates	gene	0.60
NGF	regulates	gene	0.60
PPARG	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
PRKAA1	activates	gene	0.60
LDLR	regulates	gene	0.60
APP/PS1	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GENES	regulates	gene	0.60
LDL	regulates	gene	0.60
APP	regulates	gene	0.60
POMC	activates	gene	0.60
AND	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PTGS1 in their description or question text

No additional research found