concept

ENDOTHELIAL CELL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOTHELIAL CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

470Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

8Experiments

0Debates

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💡 Concept Info

Name	ENDOTHELIAL CELL
Key Genes/Proteins	AKT, BECN1, HIF1A, MTOR, P53, STAT3

Pathway Diagram

graph TD
    ENDOTHELIAL_CELL["ENDOTHELIAL CELL"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| ENDOTHELIAL_CELL
    NEURON["NEURON"] -->|"expressed in"| ENDOTHELIAL_CELL
    REST["REST"] -->|"expressed in"| ENDOTHELIAL_CELL
    CD2AP["CD2AP"] -->|"expressed in"| ENDOTHELIAL_CELL
    ALZHEIMER["ALZHEIMER"] -->|"expressed in"| ENDOTHELIAL_CELL
    REELIN["REELIN"] -->|"expressed in"| ENDOTHELIAL_CELL
    AXON_REGENERATION["AXON REGENERATION"] -->|"expressed in"| ENDOTHELIAL_CELL
    AXON["AXON"] -->|"expressed in"| ENDOTHELIAL_CELL
    AKT["AKT"] -->|"expressed in"| ENDOTHELIAL_CELL
    JUN["JUN"] -->|"expressed in"| ENDOTHELIAL_CELL

Outgoing (53)

Target	Relation	Type	Str
NTN1	expressed_in	entity	0.90
Idiopathic Nephrotic Syndrome	involved_in	disease	0.90
DRP1	expressed_in	protein	0.85
NTN1	expressed_in	gene	0.85
Blood-Brain Barrier Function	involved_in	process	0.85
Myofibroblast	associated_with	cell_type	0.75
ENDOTHELIAL	interacts_with	concept	0.50
ENDOTHELIAL CELLS	interacts_with	concept	0.50
CENTRAL NERVOUS SYSTEM	interacts_with	concept	0.50
disease	activates	disease	0.50
TJP1	activates	concept	0.50
ENDOTHELIAL	regulates	concept	0.50
ENDOTHELIAL CELLS	regulates	concept	0.50
CELL DEATH	regulates	concept	0.50
ISCHEMIC	inhibits	concept	0.50
ISCHEMIC STROKE	inhibits	concept	0.50
ENDOTHELIAL CELLS	inhibits	concept	0.50
STEM CELLS	activates	concept	0.50
MITOPHAGY	associated_with	process	0.50
APOPTOSIS	activates	process	0.50
OXIDATIVE STRESS	activates	process	0.50
ENDOTHELIAL	activates	concept	0.50
AXON	associated_with	concept	0.50
ENDOTHELIAL	associated_with	concept	0.50
AXON REGENERATION	associated_with	concept	0.50
ENDOTHELIAL CELLS	associated_with	concept	0.50
ISCHEMIC	regulates	concept	0.50
ISCHEMIC STROKE	regulates	concept	0.50
STEM CELLS	regulates	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
Proteins	interacts_with	protein	0.50
STEM CELLS	interacts_with	concept	0.50
EXTRACELLULAR VESICLES	interacts_with	concept	0.50
ISCHEMIC	associated_with	concept	0.50
SENESCENCE	associated_with	process	0.50
AGING	regulates	process	0.50
SENESCENCE	regulates	process	0.50
AGING	protects_against	process	0.50
SENESCENCE	protects_against	process	0.50
AUTOPHAGY	activates	process	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
ENDOTHELIAL	inhibits	concept	0.50
ENDOTHELIAL	causes	concept	0.50
ENDOTHELIAL CELLS	causes	concept	0.50
IPSC	activates	concept	0.50
BLOOD-BRAIN BARRIER DYSFUNCTION	activates	concept	0.50
ENDOTHELIAL	protects_against	concept	0.50
ENDOTHELIAL	expressed_in	concept	0.50
ENDOTHELIAL CELLS	expressed_in	concept	0.50
RESVERATROL	regulates	concept	0.50

Incoming (417)

Source	Relation	Type	Str
KCNJ2	expressed_in	gene	0.95
Brain Arteriovenous Malformations	causes	disease	0.92
Circadian Clock	expressed_in	pathway	0.90
CD2AP	expressed_in	entity	0.90
STING	expressed_in	protein	0.90
Ethanol	modulates	compound	0.80
GAD1	expressed_in	gene	0.55
DTX1	expressed_in	gene	0.55
TRPA1	expressed_in	gene	0.55
ASTROCYTES	expressed_in	gene	0.55
TRKB	expressed_in	gene	0.55
INFLAMMATION	expressed_in	gene	0.55
MMP2	expressed_in	gene	0.55
AGING	expressed_in	gene	0.55
TFR1	expressed_in	gene	0.55
MICROGLIA	expressed_in	gene	0.55
TFRC	expressed_in	gene	0.55
PARKINSON'S DISEASE	expressed_in	gene	0.55
PARKINSON	expressed_in	gene	0.55
MMP9	expressed_in	gene	0.55
SIRT1	expressed_in	gene	0.55
NF-ΚB	expressed_in	gene	0.55
FERROPTOSIS	expressed_in	gene	0.55
TERC	expressed_in	gene	0.55
TERT	expressed_in	gene	0.55
P16	expressed_in	gene	0.55
IL-6	expressed_in	gene	0.55
TRPV4	expressed_in	gene	0.55
MIR-193B-5P	expressed_in	gene	0.55
ACETYL-COA	expressed_in	gene	0.55
BNIP3	expressed_in	gene	0.55
BCL2	expressed_in	gene	0.55
ATG7	expressed_in	gene	0.55
GLI1	expressed_in	gene	0.55
ATG	expressed_in	gene	0.55
EXERCISE	expressed_in	gene	0.55
DTX3L	expressed_in	gene	0.55
NOTCH1	expressed_in	gene	0.55
KLF2	expressed_in	gene	0.55
ORAI1	expressed_in	gene	0.55
BLOOD-BRAIN BARRIER DYSFUNCTION	expressed_in	gene	0.55
OVERVIEW	expressed_in	gene	0.55
HGF	expressed_in	gene	0.55
PIEZO1	expressed_in	gene	0.55
AND	expressed_in	gene	0.55
APOER2	expressed_in	gene	0.55
ARF6	expressed_in	gene	0.55
LET7A-5P	expressed_in	gene	0.55
ERK1/2	expressed_in	gene	0.55
FGF	expressed_in	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Synthetic Biology BBB Endothelial Cell Reprogramming	0.727	neurodegeneration	Blood-brain barrier transport mechanisms

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (8)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000
s:** - Compare uptake with/without magnetic particles using tight junc	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$120,000
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
AAV Serotype Comparison for LRRK2 Knockdown in PD	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
Blood-Based Biomarker Panel for Early AD Detection	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$220,000
Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur	validation	Neurodegeneration	0.400	0.50	cell_line	proposed	$130,000
Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
Vascular Contribution to Alzheimer's Disease — Beyond Amyloid	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,280,000

Related Papers (11)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Author Correction: Crystal structure of active CDK4-cyclin D and mechanistic bas [PMID:36577758]	Gharbi Severine Isabelle; Pelletier Laur	NPJ breast cancer	2022
The biology of beauty sleep. [PMID:35256810]	Jordan A Anderson; Jenny Tung	Nature ecology & evolution	2022
Cathepsin S is a novel target for age-related dry eye. [PMID:34910926]	["Yu Z", "Li J", "Govindarajan G", "Hamm	Experimental eye research	2022
Intrinsic functional neuron-type selectivity of transcranial focused ultrasound [PMID:33947867]	["Yu K", "Niu X", "Krook-Magnuson E", "H	Nature communications	2021
Warning wristbands for patients with intra-ocular gas [PMID:31745326]	Naderi Khayam; Masoero Pietro; Karthikey	Eye	2020
NK cells for cancer immunotherapy. [PMID:31907401]	["Shimasaki N", "Jain A", "Campana D"]	Nature reviews. Drug discovery	2020
Potent and specific MTH1 inhibitors targeting gastric cancer. [PMID:31164636]	["Zhou W", "Ma L", "Yang J", "Qiao H", "	Cell death & disease	2019
Clinical factors associated with worse quality-of-life scores in United States t [PMID:30898373]	["Goswami S", "Peipert B", "Mongelli M",	Surgery	2019
Arabidopsis Duodecuple Mutant of PYL ABA Receptors Reveals PYL Repression of ABA [PMID:29898403]	["Zhao Y", "Zhang Z", "Gao J", "Wang P",	Cell reports	2018
Cell transplantation therapy for spinal cord injury. [PMID:28440805]	["Assinck P", "Duncan G", "Hilton B", "P	Nature neuroscience	2017
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. [PMID:22343897]	["Ichimura A", "Hirasawa A", "Poulain-Go	Nature	2012

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ENDOTHELIAL CELL in their description or question text

No additional research found