concept

CELL PROLIFERATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CELL PROLIFERATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

439Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CELL PROLIFERATION
Key Genes/Proteins	ACVR2A, AKT, ALZHEIMER, AMPK, AQP4, AQUAPORIN-4
Related Diseases	acetylcholine, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Cell Proliferation

biological_process · 1574 words

→

Pathway Diagram

graph TD
    CELL_PROLIFERATION["CELL PROLIFERATION"]
    style CELL_PROLIFERATION fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    Luteolin["Luteolin"] -.->|"inhibits"| CELL_PROLIFERATION
    MTOR([MTOR]) -->|"regulates"| CELL_PROLIFERATION
    PI3K_AKT_mTOR["PI3K/AKT/mTOR"] -->|"regulates"| CELL_PROLIFERATION
    Shikonin["Shikonin"] -.->|"inhibits"| CELL_PROLIFERATION
    HER2([HER2]) -->|"regulates"| CELL_PROLIFERATION
    FGFR["FGFR"] -->|"regulates"| CELL_PROLIFERATION
    PI3K_AKT_MTOR["PI3K/AKT/MTOR"] -->|"regulates"| CELL_PROLIFERATION

Outgoing (143)

Target	Relation	Type	Str
Wound Healing	contributes_to	process	0.95
Esophageal Squamous Cell Carcinoma	contributes_to	disease	0.90
Esophageal Squamous Cell Carcinoma	promotes	disease	0.80
MTOR	activates	gene	0.80
METASTASIS	activates	process	0.80
PI3K	activates	gene	0.65
CHEMORESISTANCE	inhibits	phenotype	0.65
CELL DEATH	inhibits	phenotype	0.65
APOPTOSIS	treats	phenotype	0.65
PI3K/AKT PATHWAY	activates	concept	0.50
IL-17	associated_with	concept	0.50
SGMS1	associated_with	concept	0.50
CELL MIGRATION	associated_with	concept	0.50
HER2	activates	concept	0.50
RAPAMYCIN	associated_with	concept	0.50
HER2	associated_with	concept	0.50
ENDOTHELIAL CELLS	activates	cell_type	0.50
NEURON	regulates	cell_type	0.50
NEURON	activates	cell_type	0.50
INFLAMMATION	implicated_in	process	0.50
HEPATOCELLULAR CARCINOMA	activates	disease	0.50
NF-KB	regulates	gene	0.50
MTOR SIGNALING	activates	process	0.50
RAPAMYCIN	regulates	drug	0.50
CENTRAL NERVOUS SYSTEM	activates	concept	0.50
EXTRACELLULAR MATRIX	associated_with	concept	0.50
INFLAMMATION	activates	process	0.50
EGFR	activates	gene	0.50
SGMS1	regulates	concept	0.50
SLC7A11	activates	gene	0.50
FERROPTOSIS	activates	process	0.50
SRPK1	regulates	concept	0.50
SRPK1	expressed_in	concept	0.50
LUTEOLIN	associated_with	drug	0.45
MTOR SIGNALING	associated_with	pathway	0.45
PI3K/AKT PATHWAY	associated_with	pathway	0.45
BAICALEIN	associated_with	drug	0.45
CURCUMIN	associated_with	drug	0.45
PI3K/AKT/MTOR	associated_with	pathway	0.45
MTOR PATHWAY	associated_with	pathway	0.45
RIBOSOME	associated_with	organelle	0.45
MICROGLIA	activates	cell_type	0.45
IL6	activates	gene	0.45
WNT SIGNALING	associated_with	pathway	0.45
PARKIN	co_discussed	gene	0.40
PINK1	co_discussed	gene	0.40
SIRT1	co_discussed	gene	0.40
NEURON	co_discussed	cell_type	0.40
MACROPHAGE	co_discussed	cell_type	0.40
PARP1	co_discussed	gene	0.40

Incoming (296)

Source	Relation	Type	Str
Luteolin	inhibits	compound	0.95
APOPTOSIS	regulates	process	0.95
mTOR	regulates	protein	0.95
Shikonin	inhibits	compound	0.95
HER2	promotes	protein	0.95
MTOR	promotes	gene	0.95
RAS	regulates	protein	0.95
APOPTOSIS	activates	process	0.95
CANCER	activates	disease	0.95
ERBB2	regulates	gene	0.95
MTOR	regulates	entity	0.95
MTOR	promotes	gene	0.95
PI3K/AKT/mTOR	regulates	pathway	0.95
MTOR	regulates	protein	0.95
HER2	regulates	protein	0.95
Baicalein	suppresses	compound	0.95
ABLIM1	promotes	protein	0.93
PI3K/AKT/MTOR	regulates	pathway	0.93
MTORC2	mediates	protein	0.90
EGFR	regulates	gene	0.90
Gamitrinib	inhibits	drug	0.90
PTEN	inhibits	gene	0.90
JUN	inhibits	gene	0.90
Cinobufagin	inhibits	compound	0.90
PI3K-AKT-mTOR	activates	pathway	0.90
SNCA	contributes_to	protein	0.90
PI3K/AKT/mTOR	contributes_to	pathway	0.90
PRMT1	regulates	entity	0.90
PI3K/AKT Signaling Pathway	activates	pathway	0.90
TP53	regulates	gene	0.90
NPM	regulates	protein	0.90
PI3K/AKT/mTOR	regulates	pathway	0.90
NPC1	inhibits	gene	0.90
Pi3K/Akt/Mtor	promotes	pathway	0.90
PRDM4	inhibits	gene	0.90
Chrysotoxine	inhibits	compound	0.90
TRIM34	promotes	gene	0.90
Aloperine	inhibits	compound	0.90
USP36	upregulates	protein	0.90
ERK	regulates	protein	0.90
ERK	promotes	pathway	0.90
MYC	promotes	gene	0.90
Senescence	inhibits	process	0.90
Jak/Stat	mediates	pathway	0.90
USP36	promotes	enzyme	0.90
IGF2BP2	associated_with	gene	0.90
AP-1	regulates	protein	0.90
Hippo pathway	regulates	pathway	0.90
PI3K/AKT	promotes	pathway	0.90
OCLN	inhibits	protein	0.88

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CELL PROLIFERATION in their description or question text

No additional research found