concept

BLOOD-BRAIN BARRIER DYSFUNCTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BLOOD-BRAIN BARRIER DYSFUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

240Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

BLOOD-BRAIN BARRIER DYSFUNCTION is a concept in neurodegeneration research. Key relationships include: activates, contributes to, associated with. Associated with ALS, Aging, Als. Connected to 110 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	BLOOD-BRAIN BARRIER DYSFUNCTION
Key Genes/Proteins	ABCD1, ABCD2, AGING, AKT, ALS, ALZHEIMER
Related Diseases	aging, Aging, Als, Alzheimer
Related Pathways	Amyloid

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Blood-Brain Barrier Dysfunction in Neurodegeneration

mechanism · 4726 words

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Pathway Diagram

graph TD
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO["BLOOD-BRAIN BARRIER DYSFUNCTION"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"activates"| sepsis_associated_encephalopat["sepsis-associated encephalopathy"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"inhibits"| Diabetes["Diabetes"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"inhibits"| Aging["Aging"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"regulates"| Stroke["Stroke"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"inhibits"| Als["Als"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"inhibits"| Ischemia["Ischemia"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"inhibits"| Ms["Ms"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"contributes to"| Alzheimer["Alzheimer"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"contributes to"| ALS["ALS"]
    pericyte_senescence["pericyte senescence"] -->|"causes"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    pro_inflammatory_cytokines["pro-inflammatory cytokines"] -->|"activates"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    Amyloid__["Amyloid beta"] -->|"causes"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    SMAD2["SMAD2"] -->|"inhibits"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    AMYLOID["AMYLOID"] -->|"contributes to"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"contributes to"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"contributes to"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    TAU_PATHOLOGY["TAU PATHOLOGY"] -->|"contributes to"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    ALZHEIMER["ALZHEIMER"] -->|"contributes to"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    AND["AND"] -->|"contributes to"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO

Outgoing (140)

Target	Relation	Type	Str
Alzheimer's Disease	associated_with	disease	0.95
Amyloid-β Accumulation	contributes_to	mechanism	0.93
Amyloid-β Accumulation	causes	process	0.90
peripheral immune cell infiltration	promotes	process	0.88
Cognitive Decline	contributes_to	phenotype	0.85
Neurodegeneration	contributes_to	disease	0.85
Neuroinflammatory Response	promotes	process	0.85
Neuroinflammation	contributes_to	process	0.85
Stroke	associated_with	disease	0.85
Radiation-Induced Brain Injury	contributes_to	disease	0.85
Biomarker For Cognitive Decline	biomarker_for	biomarker	0.82
Alzheimer's Disease	biomarker_for	disease	0.80
Alzheimer's Disease	involved_in	disease	0.80
Neurologic Diseases	contributes_to	disease	0.80
Cns Disorders	associated_with	disease	0.80
Gray Matter Atrophy	associated_with	phenotype	0.80
Hemorrhagic Transformation	contributes_to	phenotype	0.80
Cognitive Decline	biomarker_for	phenotype	0.80
Blood-Brain Barrier	activates	pathway	0.80
Neuroinflammation	associated_with	disease	0.75
Alzheimer'S Disease	contributes_to	disease	0.75
Biomarker For Neurodegeneration	biomarker_for	biomarker	0.75
Alzheimer	activates	disease	0.75
Inflammation	associated_with	disease	0.75
Diabetes	inhibits	disease	0.75
NEUROINFLAMMATION	inhibits	phenotype	0.70
radiation-induced brain injury	associated_with	disease	0.70
ALS	associated_with	gene	0.70
sepsis-associated encephalopathy	activates	disease	0.70
neuroinflammation	associated_with	process	0.70
ALZHEIMER	activates	gene	0.70
Blood-Brain Barrier	associated_with	pathway	0.70
ALZHEIMER'S DISEASE	activates	gene	0.70
NEURODEGENERATION	treats	phenotype	0.70
ALS	activates	disease	0.65
Ms	associated_with	disease	0.65
Stroke	activates	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Traumatic Brain Injury	associated_with	disease	0.65
Stroke	regulates	disease	0.65
Als	inhibits	disease	0.65
Ischemia	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Aging	biomarker_for	disease	0.65
Dementia	biomarker_for	disease	0.65
Aging	inhibits	disease	0.65
Senescence	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
Stroke	biomarker_for	disease	0.65

Incoming (100)

Source	Relation	Type	Str
APOE4	causes	gene	0.95
TNF	causes	protein	0.95
APOE	causes	gene	0.92
APOE	drives	gene	0.92
APOE4	mediates	gene	0.90
37245027	causes	paper	0.90
APOE	mediates	gene	0.90
Neurovascular Unit Disruption	causes	process	0.90
25-Hydroxycholesterol	protects_against	compound	0.90
KCNK2	contributes_to	gene	0.90
38760857	enhances the association with	paper	0.90
KCNK2	regulates	gene	0.90
GRP78 Autoantibodies	mediates	biomarker	0.90
Pericyte Senescence	causes	phenotype	0.90
APOE	promotes	gene	0.90
USP13	associated_with	gene	0.85
USP25	associated_with	gene	0.85
CYLD	associated_with	gene	0.85
macromolecule permeability	associated_with	phenotype	0.85
Endothelium Dysfunction	causes	mechanism	0.85
Alzheimer Disease	associated_with	disease	0.85
Vascular Dementia	associated_with	disease	0.85
Uremic Toxins	contributes_to	compound	0.85
Neurovascular Unit Dysfunction	causes	mechanism	0.85
Neuroinflammation	promotes	process	0.85
Cerebral Amyloid Angiopathy	associated_with	disease	0.85
GRP78 Autoantibodies	causes	biomarker	0.85
Neuroinflammation	mediates	process	0.80
Normal Aging	causes	process	0.80
Senescent endothelial cells	contributes_to	cell_type	0.80
GFAP	associated_with	gene	0.80
VPS35 Dysregulation	contributes_to	mechanism	0.80
Hydrogel Models	targets	process	0.80
Neurovascular Coupling	associated_with	process	0.80
RAS	modulates	pathway	0.80
MMP	mediates	protein	0.75
Uremic Toxins	causes	compound	0.75
Advanced Glycation End Products	contributes_to	compound	0.75
USP13	associated_with	gene	0.75
BRCC3	contributes_to	gene	0.70
neuroinflammation	associated_with	process	0.70
pro-inflammatory cytokines	activates	protein	0.70
Amyloid β	causes	protein	0.70
NEUROINFLAMMATION	associated_with	phenotype	0.70
pericyte dysfunction	causes	mechanism	0.70
pericyte senescence	causes	process	0.70
CLU	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying digital biomarkers and ai-driven early detect

closed · Rounds: 4 · Score: 0.86 · 2026-04-01

Related Research

Hypotheses and analyses mentioning BLOOD-BRAIN BARRIER DYSFUNCTION in their description or question text

No additional research found