Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BLOOD-BRAIN BARRIER FUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | BLOOD-BRAIN BARRIER FUNCTION |
graph TD
BLOOD_BRAIN_BARRIER_FUNCTION[BLOOD-BRAIN BARRIER FUNCTION]
KLF11[KLF11] -.protects against.-> BLOOD_BRAIN_BARRIER_FUNCTION
TREK1[TREK1] -->|regulates| BLOOD_BRAIN_BARRIER_FUNCTION
Endothelial_CD2AP[Endothelial CD2AP] -->|regulates| BLOOD_BRAIN_BARRIER_FUNCTION
CD2AP[CD2AP] -->|involved_in| BLOOD_BRAIN_BARRIER_FUNCTION
Tight_And_Adherens_Junction_Pr[Tight And Adherens Junction Proteins] -->|involved_in| BLOOD_BRAIN_BARRIER_FUNCTION
Tight_Junction_Proteins[Tight Junction Proteins] -->|mediates| BLOOD_BRAIN_BARRIER_FUNCTION
KCNK2[KCNK2] -->|regulates| BLOOD_BRAIN_BARRIER_FUNCTION
USP27X[USP27X] -->|involved_in| BLOOD_BRAIN_BARRIER_FUNCTION
Endothelial_Cell[Endothelial Cell] -->|involved_in| BLOOD_BRAIN_BARRIER_FUNCTION| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| KLF11 | protects_against | entity | 0.95 |
| TREK1 | regulates | protein | 0.90 |
| KCNK2 | regulates | gene | 0.85 |
| USP27X | involved_in | gene | 0.85 |
| Tight Junction Proteins | mediates | protein | 0.85 |
| Endothelial Cell | involved_in | cell_type | 0.85 |
| Endothelial CD2AP | regulates | protein | 0.85 |
| CD2AP | involved_in | gene | 0.85 |
| Tight And Adherens Junction Proteins | involved_in | protein | 0.85 |
| MMP2 | associated_with | gene | 0.80 |
| CD2AP | regulates | gene | 0.80 |
| LRP1 | regulates | protein | 0.80 |
| SENOLYTICS | restores | drug | 0.80 |
| MMP9 | associated_with | gene | 0.80 |
| GJA1 | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning BLOOD-BRAIN BARRIER FUNCTION in their description or question text
No additional research found