concept

TMEM16A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TMEM16A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

21Outgoing

7Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TMEM16A
Key Genes/Proteins	ALZHEIMER, ALZHEIMER'S DISEASE, AND
Related Diseases	Alzheimer, Cardiovascular, Hypertension
Related Pathways	contractility

Wiki Pages (1)

Knowledge base pages for this entity

ANO1 (Anoctamin 1 (TMEM16A))

gene · 641 words

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Pathway Diagram

graph TD
    TMEM16A["TMEM16A"]
    TMEM16A -->|"regulates"| Alzheimer["Alzheimer"]
    TMEM16A -->|"regulates"| Cardiovascular["Cardiovascular"]
    TMEM16A -->|"regulates"| Hypertension["Hypertension"]
    TMEM16A -->|"regulates"| Stroke["Stroke"]
    TMEM16A -->|"regulates"| STROKE["STROKE"]
    TMEM16A -->|"regulates"| PIEZO1["PIEZO1"]
    TMEM16A -->|"regulates"| Endothelial["Endothelial"]
    TMEM16A -->|"regulates"| Neuron["Neuron"]
    TRPV4["TRPV4"] -->|"regulates"| TMEM16A
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| TMEM16A
    TRPA1["TRPA1"] -->|"regulates"| TMEM16A
    AND["AND"] -->|"regulates"| TMEM16A
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| TMEM16A
    STROKE -->|"regulates"| TMEM16A
    PIEZO1 -->|"regulates"| TMEM16A

Outgoing (21)

Target	Relation	Type	Str
Pericytes	expressed_in	cell_type	0.85
blood flow responses	associated_with	process	0.80
contractility	regulates	biological_process	0.80
Pericyte Contractility	associated_with	process	0.80
Blood Flow Regulation	associated_with	process	0.80
Blood Flow Response	associated_with	process	0.80
Hypertension	regulates	disease	0.65
Stroke	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
STROKE	regulates	gene	0.60
PIEZO1	regulates	gene	0.60
pericytes	expressed_in	cell_type	0.60
TRPV4	regulates	gene	0.60
Endothelial	regulates	cell_type	0.60
Neuron	regulates	cell_type	0.60
TRPA1	regulates	gene	0.60
Pericyte	regulates	cell_type	0.60
Endothelial Cell	expressed_in	cell_type	0.55
Pericyte	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (7)

Source	Relation	Type	Str
TRPV4	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
TRPA1	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
STROKE	regulates	gene	0.60
PIEZO1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TMEM16A in their description or question text

No additional research found