gene

KCNJ2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNJ2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

1Analyses

13Outgoing

6Incoming

0Experiments

1Debates

Summary

KCNJ2 encodes Kir2.1, an inward rectifier potassium channel critical for neuronal resting membrane potential and excitability, implicated in Alzheimer's and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	KCNJ2
Full Name	Kir2.1 Inward Rectifier Potassium Channel
Chromosome	17q24.3
Protein Family	Inward rectifier potassium channel (Kir) family
Protein Type	Channel
Function	encodes a 493-amino acid protein.
Amino Acids	493 aa
Pathways	Neurovascular Coupling
UniProt ID	P48745
NCBI Gene ID	3760
OMIM	600681
GeneCards	KCNJ2
Human Protein Atlas	KCNJ2
Transmembrane domains	Two transmembrane helices (M1 and M2) that form the channel pore
P-loop	Pore helix and selectivity filter between M1 and M2 with the highly conserved GYG sequence
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, BRAIN INJURY, C9ORF72, DEMENTIA
KG Connections	19 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNJ2 — AlphaFold P48745 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KCNJ2 — Kir2.1 Inward Rectifier Potassium Channel

gene · 528 words

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Pathway Diagram

graph TD
    KCNJ2["KCNJ2"]
    Blood_Brain_Barrier["Blood-Brain Barrier"]
    KCNJ2 -->|"regulates"| Blood_Brain_Barrier
    Traumatic_Brain_Injury{"Traumatic Brain Injury"}
    KCNJ2 -.->|"inhibits"| Traumatic_Brain_Injury
    Als{"Als"}
    KCNJ2 -.->|"inhibits"| Als
    Dementia{"Dementia"}
    KCNJ2 -.->|"inhibits"| Dementia
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    KCNJ2 -.->|"inhibits"| Amyotrophic_Lateral_Sclerosis
    DEMENTIA(["DEMENTIA"])
    KCNJ2 -.->|"inhibits"| DEMENTIA
    ALS(["ALS"])
    ALS -.->|"inhibits"| KCNJ2
    AND(["AND"])
    AND -.->|"inhibits"| KCNJ2
    TAU(["TAU"])
    TAU -.->|"inhibits"| KCNJ2
    C9ORF72(["C9ORF72"])
    C9ORF72 -.->|"inhibits"| KCNJ2
    style KCNJ2 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (13)

Target	Relation	Type	Str
endothelial cell	expressed_in	cell_type	0.95
membrane potential	regulates	phenotype	0.90
Brain Capillary Endothelial Cells	expressed_in	cell_type	0.90
Neurovascular Coupling	regulates	process	0.85
Als	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
Traumatic Brain Injury	inhibits	disease	0.65
DEMENTIA	inhibits	gene	0.60
neurodegeneration	inhibits	disease	0.60
frontotemporal dementia	inhibits	disease	0.60
CRISPR-Cas	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60

Incoming (6)

Source	Relation	Type	Str
ALS	inhibits	gene	0.60
BRAIN INJURY	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
TAU	inhibits	gene	0.60
C9ORF72	inhibits	gene	0.60
AND	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms explain how KCNJ2 inhibition mitigates TBI-induced neu

neurodegeneration | 2026-04-13 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study identifies KCNJ2 as a therapeutic target through CRISPR screening but

closed · Rounds: 4 · Score: 0.71 · 2026-04-16

Related Research

Hypotheses and analyses mentioning KCNJ2 in their description or question text

No additional research found