concept

ISCHEMIC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ISCHEMIC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

410Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ISCHEMIC is a concept in neurodegeneration research. Key relationships include: co discussed, protects against, activates. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 100 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ISCHEMIC
Key Genes/Proteins	ACHE, ADAM10, AKT, AMPK, amyotrophic lateral sclerosis, ANXA1
Related Diseases	aging, ALS, ALZHEIMER, ALZHEIMER'S, Alzheimer'S Disease

Pathway Diagram

graph TD
    ISCHEMIC["ISCHEMIC"]
    ISCHEMIC -->|"treats"| STROKE["STROKE"]
    ISCHEMIC -->|"activates"| MMP2["MMP2"]
    ISCHEMIC -->|"activates"| MMP9["MMP9"]
    ISCHEMIC -->|"activates"| MICROGLIA["MICROGLIA"]
    ISCHEMIC -.protects against.-> NEURON["NEURON"]
    ISCHEMIC -.protects against.-> NEURONS["NEURONS"]
    ISCHEMIC -->|"activates"| RIPK1["RIPK1"]
    ISCHEMIA["ISCHEMIA"] -->|"causes"| ISCHEMIC
    CELL_DEATH["CELL DEATH"] -->|"causes"| ISCHEMIC
    AMPK["AMPK"] -.protects against.-> ISCHEMIC
    AUTOPHAGY["AUTOPHAGY"] -->|"inhibits"| ISCHEMIC
    APOPTOSIS["APOPTOSIS"] -->|"promotes"| ISCHEMIC
    ATG7["ATG7"] -.protects against.-> ISCHEMIC
    BCL2["BCL2"] -.protects against.-> ISCHEMIC
    INFLAMMATION["INFLAMMATION"] -->|"impairs"| ISCHEMIC
    IL6["IL6"] -->|"inhibits"| ISCHEMIC
    DEMENTIA["DEMENTIA"] -->|"causes"| ISCHEMIC

Outgoing (132)

Target	Relation	Type	Str
NRF2	promotes	gene	0.65
NRF2	inhibits	gene	0.65
STROKE	interacts_with	disease	0.65
WHITE MATTER	causes	brain_region	0.65
NLRP3	regulates	gene	0.65
STROKE	associated_with	disease	0.65
MICROGLIA	causes	cell_type	0.65
MICROGLIA	promotes	cell_type	0.65
MACROPHAGES	targets	cell_type	0.65
MACROPHAGE	targets	cell_type	0.65
LRP1	mediates	gene	0.65
NEURONS	protects_against	cell_type	0.60
UBIQUITIN	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
MICROGLIA	expressed_in	cell_type	0.60
MICROGLIA	targets	cell_type	0.60
MICROGLIA	regulates	cell_type	0.60
MICROGLIA	interacts_with	cell_type	0.60
NEURODEGENERATION	contributes_to	disease	0.60
PARKINSON'S DISEASE	contributes_to	disease	0.60
STAT3	activates	gene	0.60
VEGF	promotes	gene	0.60
STROKE	activates	disease	0.60
MICROGLIA	activates	cell_type	0.60
NEURON	regulates	cell_type	0.60
MICROGLIA	protects_against	cell_type	0.60
MICROGLIA	contributes_to	cell_type	0.60
NEURON	protects_against	cell_type	0.60
RIPK1	activates	gene	0.60
PARKIN	interacts_with	gene	0.60
STROKE	treats	disease	0.60
STROKE	inhibits	disease	0.60
NEUTROPHIL	interacts_with	cell_type	0.60
MONOCYTE	expressed_in	cell_type	0.60
NLRP3	activates	gene	0.60
STROKE	expressed_in	disease	0.60
MACROPHAGE	expressed_in	cell_type	0.60
MONOCYTES	expressed_in	cell_type	0.60
NEURON	contributes_to	cell_type	0.60
NRF2	treats	gene	0.60
MICROGLIA	exacerbates	cell_type	0.60
MACROPHAGE	regulates	cell_type	0.60
MACROPHAGES	expressed_in	cell_type	0.60
MAPK	inhibits	gene	0.60
VEGF	expressed_in	gene	0.60
VEGF	treats	gene	0.60
MMP2	activates	gene	0.60
MMP9	activates	gene	0.60
NEUTROPHIL	exacerbates	cell_type	0.60
NEURON	interacts_with	cell_type	0.60

Incoming (278)

Source	Relation	Type	Str
IL-6	inhibits	gene	0.65
ASTROCYTES	activates	cell_type	0.65
GPX4	treats	gene	0.60
IL6	inhibits	gene	0.60
ASTROCYTE	mediates	cell_type	0.60
CANCER	contributes_to	disease	0.60
CANCER	causes	disease	0.60
HIPPOCAMPUS	impairs	brain_region	0.60
ACHE	activates	gene	0.60
ASTROCYTE	contributes_to	cell_type	0.60
ASTROCYTES	contributes_to	cell_type	0.60
ASTROCYTE	promotes	cell_type	0.60
DEPRESSION	promotes	disease	0.60
ENDOTHELIAL	transports	cell_type	0.60
BDNF	mediates	gene	0.60
ISCHEMIA	associated_with	disease	0.60
AMPK	activates	gene	0.60
ASTROCYTE	activates	cell_type	0.60
DEMENTIA	causes	disease	0.60
GFAP	associated_with	gene	0.60
ISCHEMIA	expressed_in	disease	0.60
ISCHEMIA	causes	disease	0.60
AMPK	protects_against	gene	0.60
ATG7	protects_against	gene	0.60
BCL2	protects_against	gene	0.60
ISCHEMIA	interacts_with	disease	0.60
AKT	activates	gene	0.60
ALZHEIMER	associated_with	disease	0.60
ALZHEIMER'S	associated_with	disease	0.60
ALZHEIMER'S DISEASE	associated_with	disease	0.60
ferroptosis	inhibits	phenotype	0.50
PARKINSON	associated_with	gene	0.50
aging	associated_with	phenotype	0.50
Alzheimer'S Disease	associated_with	disease	0.50
Parkinson's Disease	associated_with	disease	0.50
BRAIN INJURY	associated_with	concept	0.50
Traumatic Brain Injury	associated_with	disease	0.50
PARKINSON'S	associated_with	concept	0.50
Cardiovascular	activates	disease	0.50
Astrocytes	associated_with	cell_type	0.50
Oligodendrocyte	associated_with	cell_type	0.50
inflammation	causes	pathway	0.50
aging	activates	phenotype	0.50
Neuroinflammation	activates	process	0.50
PRDX6	activates	gene	0.50
Astrocytes	activates	cell_type	0.50
EGR1	activates	protein	0.50
apoptosis	inhibits	process	0.50
GLYCOLYSIS	inhibits	pathway	0.50
Endothelial Cell	inhibits	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ISCHEMIC in their description or question text

No additional research found